Correlated Mutation in the Evolution of Catalysis in Uracil DNA Glycosylase Superfamily

Enzymes in Uracil DNA glycosylase (UDG) superfamily are essential for the removal of uracil. Family 4 UDGa is a robust uracil DNA glycosylase that only acts on double-stranded and single-stranded uracil-containing DNA. Based on mutational, kinetic and modeling analyses, a catalytic mechanism involvi...

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Veröffentlicht in:	Scientific reports 2017-04, Vol.7 (1), p.45978, Article 45978
Hauptverfasser:	Xia, Bo, Liu, Yinling, Guevara, Jose, Li, Jing, Jilich, Celeste, Yang, Ye, Wang, Liangjiang, Dominy, Brian N., Cao, Weiguo
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 631/114/663/2009 631/181/2481 631/45/173 631/57/2272/2273 82/16 82/80 82/83 Amino Acid Sequence Amino Acid Substitution Binding Sites Biocatalysis Biological Evolution Catalysis Deoxyribonucleic acid DNA DNA glycosylase Enzymes Humanities and Social Sciences Kinetics Models, Molecular multidisciplinary Multigene Family Mutant Proteins - chemistry Mutant Proteins - metabolism Mutation Mutation - genetics Protein structure Science Sequence Alignment Single-stranded DNA Structure-function relationships Substrate Specificity Thermus thermophilus - enzymology Uracil Uracil - metabolism Uracil-DNA glycosidase Uracil-DNA Glycosidase - chemistry Uracil-DNA Glycosidase - genetics
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