Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice

Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness of...

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Veröffentlicht in:	Scientific reports 2017-04, Vol.7 (1), p.46166-46166, Article 46166
Hauptverfasser:	Sharma, Pawan, Yi, Roslyn, Nayak, Ajay P., Wang, Nadan, Tang, Francesca, Knight, Morgan J., Pan, Shi, Oliver, Brian, Deshpande, Deepak A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/21 13/51 631/154/436/2387 692/699/1785/31 82/29 96/21 96/95 Airway Remodeling - drug effects Albumin Allergens Allergens - immunology Animal models Animals Asthma Asthma - drug therapy Asthma - immunology Asthma - physiopathology Asthma - prevention & control Bitter taste Bronchial Hyperreactivity - complications Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - pathology Bronchial Hyperreactivity - physiopathology Bronchoalveolar Lavage Fluid - cytology Bronchodilators Cell Count Chemokines Chemotaxis Chemotaxis - drug effects Chloroquine Chloroquine - therapeutic use Cytokines Cytokines - metabolism Disease Models, Animal Extracellular matrix Female House dust Humanities and Social Sciences Humans Hypersensitivity - drug therapy Hypersensitivity - immunology Hypersensitivity - physiopathology Hypersensitivity - prevention & control Immunization Inflammation Inflammation - complications Inflammation - pathology Leukocytes (neutrophilic) Lung - immunology Lung - parasitology Lung - pathology Lung - physiopathology Matrix Metalloproteinases - metabolism Mice, Inbred BALB C Mucus - metabolism multidisciplinary Muscle, Smooth - drug effects Muscle, Smooth - pathology Neutrophils - drug effects Ova Pyroglyphidae - drug effects Quinine Quinine - therapeutic use Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism Respiratory tract Respiratory tract diseases Rodents Science Smooth muscle Taste Taste receptors
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