Telocytes: a potential defender in the spleen of Npc1 mutant mice
Niemann–Pick disease, type C1 (Npc1), is an atypical lysosomal storage disorder caused by autosomal recessive inheritance of mutations in Npc1 gene. In the Npc1 mutant mice (Npc1−/−), the initial manifestation is enlarged spleen, concomitant with free cholesterol accumulation. Telocytes (TCs), a nov...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2017-05, Vol.21 (5), p.848-859 |
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| creator | Zhang, Bichao Yang, Ciqing Qiao, Liang Li, Qiuling Wang, Congrui Yan, Xin Lin, Juntang |
| description | Niemann–Pick disease, type C1 (Npc1), is an atypical lysosomal storage disorder caused by autosomal recessive inheritance of mutations in Npc1 gene. In the Npc1 mutant mice (Npc1−/−), the initial manifestation is enlarged spleen, concomitant with free cholesterol accumulation. Telocytes (TCs), a novel type of interstitial cell, exist in a variety of tissues including spleen, presumably thought to be involved in many biological processes such as nursing stem cells and recruiting inflammatory cells. In this study, we found that the spleen is significantly enlarged in Npc1−/− mice, and the results from transmission electron microscopy examination and immunostaining using three different TCs markers, c‐Kit, CD34 and Vimentin revealed significantly increased splenic TCs in Npc1−/− mice. Furthermore, hematopoietic stem cells and macrophages were also elevated in Npc1−/− spleen. Taken together, our data indicate that splenic TCs might alleviate the progress of splenic malfunction via recruiting hematopoietic stem cells and macrophages. |
| doi_str_mv | 10.1111/jcmm.13024 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5387173</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2290823989</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4484-7aedc4af90faf35422a11745821fbdbfde60149b4fff8d5084da1fcfb129ce3c3</originalsourceid><addsrcrecordid>eNp9kU1r3DAQhkVoaDZpL_kBRdBLCWyikeS11EMhLPlkk17Ss5DlUdeLbbmWnbD_Pkp2u6Q9ZC4a0MPDO7yEHAM7hTRnK9c0pyAYl3tkApniU6mF_LDdQQl1QA5jXDEmZiD0R3LAczVLeDYh5w9YB7ceMH6nlnZhwHaobE1L9NiW2NOqpcMSaexqxJYGT-87B7QZB9sOtKkcfiL73tYRP2_fI_Lr8uJhfj1d_Ly6mZ8vpk5KJae5xdJJ6zXz1otMcm4BcpkSgi_Kwpc4YyB1Ib33qsyYkqUF73wBXDsUThyRHxtvNxZNcqWgva1N11eN7dcm2Mr8-9NWS_M7PJpMqBxykQTftoI-_BkxDqaposO6ti2GMRpQEhTj-hX9-h-6CmPfpvMM55opLrTSiTrZUK4PMfbod2GAmZdmzEsz5rWZBH95G3-H_q0iAbABnqoa1--ozO387m4jfQaRIJk6</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2290823989</pqid></control><display><type>article</type><title>Telocytes: a potential defender in the spleen of Npc1 mutant mice</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><creator>Zhang, Bichao ; Yang, Ciqing ; Qiao, Liang ; Li, Qiuling ; Wang, Congrui ; Yan, Xin ; Lin, Juntang</creator><creatorcontrib>Zhang, Bichao ; Yang, Ciqing ; Qiao, Liang ; Li, Qiuling ; Wang, Congrui ; Yan, Xin ; Lin, Juntang</creatorcontrib><description>Niemann–Pick disease, type C1 (Npc1), is an atypical lysosomal storage disorder caused by autosomal recessive inheritance of mutations in Npc1 gene. In the Npc1 mutant mice (Npc1−/−), the initial manifestation is enlarged spleen, concomitant with free cholesterol accumulation. Telocytes (TCs), a novel type of interstitial cell, exist in a variety of tissues including spleen, presumably thought to be involved in many biological processes such as nursing stem cells and recruiting inflammatory cells. In this study, we found that the spleen is significantly enlarged in Npc1−/− mice, and the results from transmission electron microscopy examination and immunostaining using three different TCs markers, c‐Kit, CD34 and Vimentin revealed significantly increased splenic TCs in Npc1−/− mice. Furthermore, hematopoietic stem cells and macrophages were also elevated in Npc1−/− spleen. Taken together, our data indicate that splenic TCs might alleviate the progress of splenic malfunction via recruiting hematopoietic stem cells and macrophages.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.13024</identifier><identifier>PMID: 27860245</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Animals ; Antigens, CD - metabolism ; Antigens, CD34 - metabolism ; Antigens, Differentiation, Myelomonocytic - metabolism ; Autosomal recessive inheritance ; CD34 antigen ; Cell Count ; Cholesterol ; Fluorescent Antibody Technique ; Hematopoietic stem cells ; Hereditary diseases ; Heredity ; Inflammation ; Lipids ; Macrophages ; Macrophages - metabolism ; Male ; Medical research ; Mice ; Mice, Mutant Strains ; Mutation ; Nanog Homeobox Protein - metabolism ; Niemann-Pick disease ; Niemann–Pick disease, type C1 ; Npc1 protein ; Nursing ; Original ; Pluripotent Stem Cells - metabolism ; Proteins - metabolism ; Proto-Oncogene Proteins c-kit - metabolism ; Software ; Spleen ; Spleen - metabolism ; Spleen - pathology ; Spleen - ultrastructure ; Stem cell transplantation ; Stem cells ; telocytes ; Telocytes - metabolism ; Telocytes - pathology ; Telocytes - ultrastructure ; Transmission electron microscopy ; Vimentin ; Vimentin - metabolism</subject><ispartof>Journal of cellular and molecular medicine, 2017-05, Vol.21 (5), p.848-859</ispartof><rights>2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4484-7aedc4af90faf35422a11745821fbdbfde60149b4fff8d5084da1fcfb129ce3c3</citedby><cites>FETCH-LOGICAL-c4484-7aedc4af90faf35422a11745821fbdbfde60149b4fff8d5084da1fcfb129ce3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387173/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387173/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11542,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27860245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Bichao</creatorcontrib><creatorcontrib>Yang, Ciqing</creatorcontrib><creatorcontrib>Qiao, Liang</creatorcontrib><creatorcontrib>Li, Qiuling</creatorcontrib><creatorcontrib>Wang, Congrui</creatorcontrib><creatorcontrib>Yan, Xin</creatorcontrib><creatorcontrib>Lin, Juntang</creatorcontrib><title>Telocytes: a potential defender in the spleen of Npc1 mutant mice</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Niemann–Pick disease, type C1 (Npc1), is an atypical lysosomal storage disorder caused by autosomal recessive inheritance of mutations in Npc1 gene. In the Npc1 mutant mice (Npc1−/−), the initial manifestation is enlarged spleen, concomitant with free cholesterol accumulation. Telocytes (TCs), a novel type of interstitial cell, exist in a variety of tissues including spleen, presumably thought to be involved in many biological processes such as nursing stem cells and recruiting inflammatory cells. In this study, we found that the spleen is significantly enlarged in Npc1−/− mice, and the results from transmission electron microscopy examination and immunostaining using three different TCs markers, c‐Kit, CD34 and Vimentin revealed significantly increased splenic TCs in Npc1−/− mice. Furthermore, hematopoietic stem cells and macrophages were also elevated in Npc1−/− spleen. Taken together, our data indicate that splenic TCs might alleviate the progress of splenic malfunction via recruiting hematopoietic stem cells and macrophages.</description><subject>Animals</subject><subject>Antigens, CD - metabolism</subject><subject>Antigens, CD34 - metabolism</subject><subject>Antigens, Differentiation, Myelomonocytic - metabolism</subject><subject>Autosomal recessive inheritance</subject><subject>CD34 antigen</subject><subject>Cell Count</subject><subject>Cholesterol</subject><subject>Fluorescent Antibody Technique</subject><subject>Hematopoietic stem cells</subject><subject>Hereditary diseases</subject><subject>Heredity</subject><subject>Inflammation</subject><subject>Lipids</subject><subject>Macrophages</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Medical research</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Mutation</subject><subject>Nanog Homeobox Protein - metabolism</subject><subject>Niemann-Pick disease</subject><subject>Niemann–Pick disease, type C1</subject><subject>Npc1 protein</subject><subject>Nursing</subject><subject>Original</subject><subject>Pluripotent Stem Cells - metabolism</subject><subject>Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-kit - metabolism</subject><subject>Software</subject><subject>Spleen</subject><subject>Spleen - metabolism</subject><subject>Spleen - pathology</subject><subject>Spleen - ultrastructure</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>telocytes</subject><subject>Telocytes - metabolism</subject><subject>Telocytes - pathology</subject><subject>Telocytes - ultrastructure</subject><subject>Transmission electron microscopy</subject><subject>Vimentin</subject><subject>Vimentin - metabolism</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1r3DAQhkVoaDZpL_kBRdBLCWyikeS11EMhLPlkk17Ss5DlUdeLbbmWnbD_Pkp2u6Q9ZC4a0MPDO7yEHAM7hTRnK9c0pyAYl3tkApniU6mF_LDdQQl1QA5jXDEmZiD0R3LAczVLeDYh5w9YB7ceMH6nlnZhwHaobE1L9NiW2NOqpcMSaexqxJYGT-87B7QZB9sOtKkcfiL73tYRP2_fI_Lr8uJhfj1d_Ly6mZ8vpk5KJae5xdJJ6zXz1otMcm4BcpkSgi_Kwpc4YyB1Ib33qsyYkqUF73wBXDsUThyRHxtvNxZNcqWgva1N11eN7dcm2Mr8-9NWS_M7PJpMqBxykQTftoI-_BkxDqaposO6ti2GMRpQEhTj-hX9-h-6CmPfpvMM55opLrTSiTrZUK4PMfbod2GAmZdmzEsz5rWZBH95G3-H_q0iAbABnqoa1--ozO387m4jfQaRIJk6</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Zhang, Bichao</creator><creator>Yang, Ciqing</creator><creator>Qiao, Liang</creator><creator>Li, Qiuling</creator><creator>Wang, Congrui</creator><creator>Yan, Xin</creator><creator>Lin, Juntang</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201705</creationdate><title>Telocytes: a potential defender in the spleen of Npc1 mutant mice</title><author>Zhang, Bichao ; Yang, Ciqing ; Qiao, Liang ; Li, Qiuling ; Wang, Congrui ; Yan, Xin ; Lin, Juntang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4484-7aedc4af90faf35422a11745821fbdbfde60149b4fff8d5084da1fcfb129ce3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antigens, CD - metabolism</topic><topic>Antigens, CD34 - metabolism</topic><topic>Antigens, Differentiation, Myelomonocytic - metabolism</topic><topic>Autosomal recessive inheritance</topic><topic>CD34 antigen</topic><topic>Cell Count</topic><topic>Cholesterol</topic><topic>Fluorescent Antibody Technique</topic><topic>Hematopoietic stem cells</topic><topic>Hereditary diseases</topic><topic>Heredity</topic><topic>Inflammation</topic><topic>Lipids</topic><topic>Macrophages</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Medical research</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Mutation</topic><topic>Nanog Homeobox Protein - metabolism</topic><topic>Niemann-Pick disease</topic><topic>Niemann–Pick disease, type C1</topic><topic>Npc1 protein</topic><topic>Nursing</topic><topic>Original</topic><topic>Pluripotent Stem Cells - metabolism</topic><topic>Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-kit - metabolism</topic><topic>Software</topic><topic>Spleen</topic><topic>Spleen - metabolism</topic><topic>Spleen - pathology</topic><topic>Spleen - ultrastructure</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>telocytes</topic><topic>Telocytes - metabolism</topic><topic>Telocytes - pathology</topic><topic>Telocytes - ultrastructure</topic><topic>Transmission electron microscopy</topic><topic>Vimentin</topic><topic>Vimentin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Bichao</creatorcontrib><creatorcontrib>Yang, Ciqing</creatorcontrib><creatorcontrib>Qiao, Liang</creatorcontrib><creatorcontrib>Li, Qiuling</creatorcontrib><creatorcontrib>Wang, Congrui</creatorcontrib><creatorcontrib>Yan, Xin</creatorcontrib><creatorcontrib>Lin, Juntang</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Bichao</au><au>Yang, Ciqing</au><au>Qiao, Liang</au><au>Li, Qiuling</au><au>Wang, Congrui</au><au>Yan, Xin</au><au>Lin, Juntang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Telocytes: a potential defender in the spleen of Npc1 mutant mice</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2017-05</date><risdate>2017</risdate><volume>21</volume><issue>5</issue><spage>848</spage><epage>859</epage><pages>848-859</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>Niemann–Pick disease, type C1 (Npc1), is an atypical lysosomal storage disorder caused by autosomal recessive inheritance of mutations in Npc1 gene. In the Npc1 mutant mice (Npc1−/−), the initial manifestation is enlarged spleen, concomitant with free cholesterol accumulation. Telocytes (TCs), a novel type of interstitial cell, exist in a variety of tissues including spleen, presumably thought to be involved in many biological processes such as nursing stem cells and recruiting inflammatory cells. In this study, we found that the spleen is significantly enlarged in Npc1−/− mice, and the results from transmission electron microscopy examination and immunostaining using three different TCs markers, c‐Kit, CD34 and Vimentin revealed significantly increased splenic TCs in Npc1−/− mice. Furthermore, hematopoietic stem cells and macrophages were also elevated in Npc1−/− spleen. Taken together, our data indicate that splenic TCs might alleviate the progress of splenic malfunction via recruiting hematopoietic stem cells and macrophages.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>27860245</pmid><doi>10.1111/jcmm.13024</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antigens, CD - metabolism Antigens, CD34 - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Autosomal recessive inheritance CD34 antigen Cell Count Cholesterol Fluorescent Antibody Technique Hematopoietic stem cells Hereditary diseases Heredity Inflammation Lipids Macrophages Macrophages - metabolism Male Medical research Mice Mice, Mutant Strains Mutation Nanog Homeobox Protein - metabolism Niemann-Pick disease Niemann–Pick disease, type C1 Npc1 protein Nursing Original Pluripotent Stem Cells - metabolism Proteins - metabolism Proto-Oncogene Proteins c-kit - metabolism Software Spleen Spleen - metabolism Spleen - pathology Spleen - ultrastructure Stem cell transplantation Stem cells telocytes Telocytes - metabolism Telocytes - pathology Telocytes - ultrastructure Transmission electron microscopy Vimentin Vimentin - metabolism |
| title | Telocytes: a potential defender in the spleen of Npc1 mutant mice |
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