The clinical use of the platelet/lymphocyte ratio and lymphocyte/monocyte ratio as prognostic predictors in colorectal cancer: a meta-analysis
Conflicting evidence exists regarding the effects of platelet/lymphocyte ratio (PLR) and lymphocyte/monocyte ratio(LMR) on the prognosis of colorectal cancer (CRC) patients. This study aimed to evaluate the roles of the PLR and LMR in predicting the prognosis of CRC patients via meta-analysis. Eligi...
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Veröffentlicht in: | Oncotarget 2017-03, Vol.8 (12), p.20011-20024 |
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creator | Guo, Ya-Huan Sun, Hai-Feng Zhang, Yan-Bing Liao, Zi-Jun Zhao, Lei Cui, Jie Wu, Tao Lu, Jian-Rong Nan, Ke-Jun Wang, Shu-Hong |
description | Conflicting evidence exists regarding the effects of platelet/lymphocyte ratio (PLR) and lymphocyte/monocyte ratio(LMR) on the prognosis of colorectal cancer (CRC) patients. This study aimed to evaluate the roles of the PLR and LMR in predicting the prognosis of CRC patients via meta-analysis.
Eligible studies were retrieved from the PubMed, Embase,andChina National Knowledge Infrastructure (CNKI) databases, supplemented by a manual search of references from retrieved articles. Pooled hazard ratios (HR) with 95% confidence intervals (95% CI) were calculated using the generic inverse variance and random-effect model to evaluate the association of PLR and LMR with prognostic variables in CRC, including overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS).
Thirty-three studies containing 15,404 patients met criteria for inclusion. Pooled analysis suggested that elevated PLR was associated with poorer OS (pooled HR = 1.57, 95% CI: 1.41 - 1.75, p< 0.00001, I2=26%) and DFS (pooled HR = 1.58, 95% CI: 1.31 - 1.92, p< 0.00001, I2=66%). Conversely, high LMR correlated with more favorable OS (pooled HR = 0.59, 95% CI: 0.50 - 0.68, p< 0.00001, I2=44%), CSS (pooled HR = 0.54, 95% CI: 0.40 - 0.72, p< 0.00001, I2=11%) and DFS (pooled HR = 0.82, 95% CI: 0.71- 0.94,p=0.005, I2=29%).
Elevated PLR was associated with poor prognosis, while high LMR correlated with more favorable outcomes in CRC patients. Pretreatment PLR and LMR could serve as prognostic predictors in CRC patients. |
doi_str_mv | 10.18632/oncotarget.15311 |
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fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5386740</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1869965351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-469b874d752d40660c8389e12c569302be383c812646acdf0b566fbddd0f59a33</originalsourceid><addsrcrecordid>eNpVkU1rHDEMhk1paUKaH9BL8bGXyY7tsdfuoVBCvyDQS3o2Hlmz6-Kxp7a3sH8iv7nTJM2HLhJ6pVeCh5C3rL9gWgm-yQlyc2WH7YJJwdgLcsrMYDoupXj5pD4h57X-6teQw1Zz85qccM3ZP-mU3FzvkUIMKYCL9FCR5om2tbdE1zBi28TjvOwzHBvS4lrI1CVPH5ubOadnaqVLybuUawuwlugDtFwqDYlCjrkgtPUSuARYPlBHZ2yuc8nFYw31DXk1uVjx_D6fkZ9fPl9ffuuufnz9fvnpqoOB89YNyox6O_it5H7olepBC22QcZDKiJ6PKLQAzbgalAM_9aNUahq99_0kjRPijHy8810O44weMLXiol1KmF052uyCfa6ksLe7_MdKodV26FeD9_cGJf8-YG12DhUwRpcwH6pdERmjpJBsHWV3o1ByrQWnhzOst7co7SNKe4ty3Xn39L-Hjf_gxF97U6FE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1869965351</pqid></control><display><type>article</type><title>The clinical use of the platelet/lymphocyte ratio and lymphocyte/monocyte ratio as prognostic predictors in colorectal cancer: a meta-analysis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><source>Free E- Journals</source><creator>Guo, Ya-Huan ; Sun, Hai-Feng ; Zhang, Yan-Bing ; Liao, Zi-Jun ; Zhao, Lei ; Cui, Jie ; Wu, Tao ; Lu, Jian-Rong ; Nan, Ke-Jun ; Wang, Shu-Hong</creator><creatorcontrib>Guo, Ya-Huan ; Sun, Hai-Feng ; Zhang, Yan-Bing ; Liao, Zi-Jun ; Zhao, Lei ; Cui, Jie ; Wu, Tao ; Lu, Jian-Rong ; Nan, Ke-Jun ; Wang, Shu-Hong</creatorcontrib><description>Conflicting evidence exists regarding the effects of platelet/lymphocyte ratio (PLR) and lymphocyte/monocyte ratio(LMR) on the prognosis of colorectal cancer (CRC) patients. This study aimed to evaluate the roles of the PLR and LMR in predicting the prognosis of CRC patients via meta-analysis.
Eligible studies were retrieved from the PubMed, Embase,andChina National Knowledge Infrastructure (CNKI) databases, supplemented by a manual search of references from retrieved articles. Pooled hazard ratios (HR) with 95% confidence intervals (95% CI) were calculated using the generic inverse variance and random-effect model to evaluate the association of PLR and LMR with prognostic variables in CRC, including overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS).
Thirty-three studies containing 15,404 patients met criteria for inclusion. Pooled analysis suggested that elevated PLR was associated with poorer OS (pooled HR = 1.57, 95% CI: 1.41 - 1.75, p< 0.00001, I2=26%) and DFS (pooled HR = 1.58, 95% CI: 1.31 - 1.92, p< 0.00001, I2=66%). Conversely, high LMR correlated with more favorable OS (pooled HR = 0.59, 95% CI: 0.50 - 0.68, p< 0.00001, I2=44%), CSS (pooled HR = 0.54, 95% CI: 0.40 - 0.72, p< 0.00001, I2=11%) and DFS (pooled HR = 0.82, 95% CI: 0.71- 0.94,p=0.005, I2=29%).
Elevated PLR was associated with poor prognosis, while high LMR correlated with more favorable outcomes in CRC patients. Pretreatment PLR and LMR could serve as prognostic predictors in CRC patients.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.15311</identifier><identifier>PMID: 28212553</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Blood Cell Count ; Blood Platelets - pathology ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - therapy ; Humans ; Lymphocytes - pathology ; Monocytes - pathology ; Prognosis ; Research Paper</subject><ispartof>Oncotarget, 2017-03, Vol.8 (12), p.20011-20024</ispartof><rights>Copyright: © 2017 Guo et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-469b874d752d40660c8389e12c569302be383c812646acdf0b566fbddd0f59a33</citedby><cites>FETCH-LOGICAL-c422t-469b874d752d40660c8389e12c569302be383c812646acdf0b566fbddd0f59a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386740/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386740/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28212553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Ya-Huan</creatorcontrib><creatorcontrib>Sun, Hai-Feng</creatorcontrib><creatorcontrib>Zhang, Yan-Bing</creatorcontrib><creatorcontrib>Liao, Zi-Jun</creatorcontrib><creatorcontrib>Zhao, Lei</creatorcontrib><creatorcontrib>Cui, Jie</creatorcontrib><creatorcontrib>Wu, Tao</creatorcontrib><creatorcontrib>Lu, Jian-Rong</creatorcontrib><creatorcontrib>Nan, Ke-Jun</creatorcontrib><creatorcontrib>Wang, Shu-Hong</creatorcontrib><title>The clinical use of the platelet/lymphocyte ratio and lymphocyte/monocyte ratio as prognostic predictors in colorectal cancer: a meta-analysis</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>Conflicting evidence exists regarding the effects of platelet/lymphocyte ratio (PLR) and lymphocyte/monocyte ratio(LMR) on the prognosis of colorectal cancer (CRC) patients. This study aimed to evaluate the roles of the PLR and LMR in predicting the prognosis of CRC patients via meta-analysis.
Eligible studies were retrieved from the PubMed, Embase,andChina National Knowledge Infrastructure (CNKI) databases, supplemented by a manual search of references from retrieved articles. Pooled hazard ratios (HR) with 95% confidence intervals (95% CI) were calculated using the generic inverse variance and random-effect model to evaluate the association of PLR and LMR with prognostic variables in CRC, including overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS).
Thirty-three studies containing 15,404 patients met criteria for inclusion. Pooled analysis suggested that elevated PLR was associated with poorer OS (pooled HR = 1.57, 95% CI: 1.41 - 1.75, p< 0.00001, I2=26%) and DFS (pooled HR = 1.58, 95% CI: 1.31 - 1.92, p< 0.00001, I2=66%). Conversely, high LMR correlated with more favorable OS (pooled HR = 0.59, 95% CI: 0.50 - 0.68, p< 0.00001, I2=44%), CSS (pooled HR = 0.54, 95% CI: 0.40 - 0.72, p< 0.00001, I2=11%) and DFS (pooled HR = 0.82, 95% CI: 0.71- 0.94,p=0.005, I2=29%).
Elevated PLR was associated with poor prognosis, while high LMR correlated with more favorable outcomes in CRC patients. Pretreatment PLR and LMR could serve as prognostic predictors in CRC patients.</description><subject>Blood Cell Count</subject><subject>Blood Platelets - pathology</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - therapy</subject><subject>Humans</subject><subject>Lymphocytes - pathology</subject><subject>Monocytes - pathology</subject><subject>Prognosis</subject><subject>Research Paper</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1rHDEMhk1paUKaH9BL8bGXyY7tsdfuoVBCvyDQS3o2Hlmz6-Kxp7a3sH8iv7nTJM2HLhJ6pVeCh5C3rL9gWgm-yQlyc2WH7YJJwdgLcsrMYDoupXj5pD4h57X-6teQw1Zz85qccM3ZP-mU3FzvkUIMKYCL9FCR5om2tbdE1zBi28TjvOwzHBvS4lrI1CVPH5ubOadnaqVLybuUawuwlugDtFwqDYlCjrkgtPUSuARYPlBHZ2yuc8nFYw31DXk1uVjx_D6fkZ9fPl9ffuuufnz9fvnpqoOB89YNyox6O_it5H7olepBC22QcZDKiJ6PKLQAzbgalAM_9aNUahq99_0kjRPijHy8810O44weMLXiol1KmF052uyCfa6ksLe7_MdKodV26FeD9_cGJf8-YG12DhUwRpcwH6pdERmjpJBsHWV3o1ByrQWnhzOst7co7SNKe4ty3Xn39L-Hjf_gxF97U6FE</recordid><startdate>20170321</startdate><enddate>20170321</enddate><creator>Guo, Ya-Huan</creator><creator>Sun, Hai-Feng</creator><creator>Zhang, Yan-Bing</creator><creator>Liao, Zi-Jun</creator><creator>Zhao, Lei</creator><creator>Cui, Jie</creator><creator>Wu, Tao</creator><creator>Lu, Jian-Rong</creator><creator>Nan, Ke-Jun</creator><creator>Wang, Shu-Hong</creator><general>Impact Journals LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170321</creationdate><title>The clinical use of the platelet/lymphocyte ratio and lymphocyte/monocyte ratio as prognostic predictors in colorectal cancer: a meta-analysis</title><author>Guo, Ya-Huan ; Sun, Hai-Feng ; Zhang, Yan-Bing ; Liao, Zi-Jun ; Zhao, Lei ; Cui, Jie ; Wu, Tao ; Lu, Jian-Rong ; Nan, Ke-Jun ; Wang, Shu-Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-469b874d752d40660c8389e12c569302be383c812646acdf0b566fbddd0f59a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Blood Cell Count</topic><topic>Blood Platelets - pathology</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - therapy</topic><topic>Humans</topic><topic>Lymphocytes - pathology</topic><topic>Monocytes - pathology</topic><topic>Prognosis</topic><topic>Research Paper</topic><toplevel>online_resources</toplevel><creatorcontrib>Guo, Ya-Huan</creatorcontrib><creatorcontrib>Sun, Hai-Feng</creatorcontrib><creatorcontrib>Zhang, Yan-Bing</creatorcontrib><creatorcontrib>Liao, Zi-Jun</creatorcontrib><creatorcontrib>Zhao, Lei</creatorcontrib><creatorcontrib>Cui, Jie</creatorcontrib><creatorcontrib>Wu, Tao</creatorcontrib><creatorcontrib>Lu, Jian-Rong</creatorcontrib><creatorcontrib>Nan, Ke-Jun</creatorcontrib><creatorcontrib>Wang, Shu-Hong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Ya-Huan</au><au>Sun, Hai-Feng</au><au>Zhang, Yan-Bing</au><au>Liao, Zi-Jun</au><au>Zhao, Lei</au><au>Cui, Jie</au><au>Wu, Tao</au><au>Lu, Jian-Rong</au><au>Nan, Ke-Jun</au><au>Wang, Shu-Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical use of the platelet/lymphocyte ratio and lymphocyte/monocyte ratio as prognostic predictors in colorectal cancer: a meta-analysis</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-03-21</date><risdate>2017</risdate><volume>8</volume><issue>12</issue><spage>20011</spage><epage>20024</epage><pages>20011-20024</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>Conflicting evidence exists regarding the effects of platelet/lymphocyte ratio (PLR) and lymphocyte/monocyte ratio(LMR) on the prognosis of colorectal cancer (CRC) patients. This study aimed to evaluate the roles of the PLR and LMR in predicting the prognosis of CRC patients via meta-analysis.
Eligible studies were retrieved from the PubMed, Embase,andChina National Knowledge Infrastructure (CNKI) databases, supplemented by a manual search of references from retrieved articles. Pooled hazard ratios (HR) with 95% confidence intervals (95% CI) were calculated using the generic inverse variance and random-effect model to evaluate the association of PLR and LMR with prognostic variables in CRC, including overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS).
Thirty-three studies containing 15,404 patients met criteria for inclusion. Pooled analysis suggested that elevated PLR was associated with poorer OS (pooled HR = 1.57, 95% CI: 1.41 - 1.75, p< 0.00001, I2=26%) and DFS (pooled HR = 1.58, 95% CI: 1.31 - 1.92, p< 0.00001, I2=66%). Conversely, high LMR correlated with more favorable OS (pooled HR = 0.59, 95% CI: 0.50 - 0.68, p< 0.00001, I2=44%), CSS (pooled HR = 0.54, 95% CI: 0.40 - 0.72, p< 0.00001, I2=11%) and DFS (pooled HR = 0.82, 95% CI: 0.71- 0.94,p=0.005, I2=29%).
Elevated PLR was associated with poor prognosis, while high LMR correlated with more favorable outcomes in CRC patients. Pretreatment PLR and LMR could serve as prognostic predictors in CRC patients.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>28212553</pmid><doi>10.18632/oncotarget.15311</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Blood Cell Count Blood Platelets - pathology Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Humans Lymphocytes - pathology Monocytes - pathology Prognosis Research Paper |
title | The clinical use of the platelet/lymphocyte ratio and lymphocyte/monocyte ratio as prognostic predictors in colorectal cancer: a meta-analysis |
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