Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1

The antitumor effect of luteolin, a plant flavonoid, in gastric cancer (GC) cells has not been fully understood. Here we show that luteolin selectively kills STAT3 overactivated GC cells that are often drug resistant. The treatment of luteolin in these GC cells significantly inhibited STAT3 phosphor...

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Veröffentlicht in:	Cell death & disease 2017-02, Vol.8 (2), p.e2612-e2612
Hauptverfasser:	Song, Shiyu, Su, Zhonglan, Xu, Hui, Niu, Mengyuan, Chen, Xiufang, Min, Haiyan, Zhang, Bin, Sun, Guibo, Xie, Sijing, Wang, Hongwei, Gao, Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/89 13/95 64/60 82/51 96/1 96/2 Animals Antibodies Antineoplastic Agents - pharmacology Apoptosis - drug effects bcl-X Protein - metabolism Biochemistry Cell Biology Cell Culture Cell Line, Tumor Cellular biology Drug resistance Flavonoids Gastric cancer HSP90 Heat-Shock Proteins - metabolism Humans Immunology Inhibitor of Apoptosis Proteins - metabolism Life Sciences Luteolin - pharmacology Male Mice Mice, Inbred BALB C Mice, Nude Myeloid Cell Leukemia Sequence 1 Protein - metabolism Original original-article Phosphorylation - drug effects Protein Binding - drug effects Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism STAT3 Transcription Factor - metabolism Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism
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