Effects of gene polymorphisms in the endoplasmic reticulum stress pathway on clinical outcomes of chemoradiotherapy in Chinese patients with nasopharyngeal carcinoma
There is considerable inter-individual variabil¬ity in chemoradiotherapy responses in nasopharyngeal carcinoma (NPC) patients receiv¬ing the same or similar treatment protocols. In this study we evaluated the association between the gene polymorphisms in endoplasmic reticulum (ER) stress pathway and...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2017-04, Vol.38 (4), p.571-580 |
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| creator | Guo, Xiao-bin Ma, Wan-le Liu, Li-juan Huang, Yu-ling Wang, Jing Huang, Li-hua Peng, Xiang-dong Yin, Ji-ye Li, Jin-gao Chen, Shao-jun Yang, Guo-ping Wang, Hui Guo, Cheng-xian |
| description | There is considerable inter-individual variabil¬ity in chemoradiotherapy responses in nasopharyngeal carcinoma (NPC) patients receiv¬ing the same or similar treatment protocols. In this study we evaluated the association between the gene polymorphisms in endoplasmic reticulum (ER) stress pathway and chemoradiation responses in Chinese NPC patients. A total of 150 patients with histopathologically conformed NPC and treated with concurrent chemoradiotherapy were enrolled. Genotypes in ER stress pathway genes, including VCP (valosin-containing protein) rs2074549, HSP90B1 rs17034943, CANX (calnexin) rs7566, HSPA5 [heat shock protein family A (Hsp70) member 5] rs430397, CALCR (calcitonin receptor) rs2528521, and XBP1 (X-box binding protein 1) rs2269577 were analyzed by Sequenom MassARRAY system. The short-term effects of primary tumor and lymph node after radiotherapy were assessed based on the Response Evaluation Criteria in Solid Tumors (RECIST) of WHO. And acute radiation-induced toxic reactions were evaluated according to the Radiation Therapy Oncology Group or European Organization for Research and Treatment of Cancer (RTOG/EORTC). The effects of gene polymorphisms on clinical outcomes of chemoradiotherapy were assessed by chi-square test, univariate and multivariate logistic regression analyses. We found that CT and CT+CC genotypes of CANX rs7566 was significantly correlated with primary tumor treatment efficacy at 3 months after chemoradiotherapy and with occurrence of radiation-induced myelosuppression in Chinese NPC patients. CT and CT+CC genotypes of CALCR rs2528521 were significantly correlated with cervical lymph node efficacy at 3 months after chemoradiotherapy. And CC and CT+CC genotypes of VCP rs2074549 were significantly associated with occurrence of myelosuppression. In conclusion, SNPs of VCP rs2074549, CANX rs7566 and CALCR rs2528521 in ER stress pathway genes may serve as predictors for clinical outcomes of chemoradiotherapy in Chinese NPC patients. |
| doi_str_mv | 10.1038/aps.2016.148 |
| format | Article |
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In this study we evaluated the association between the gene polymorphisms in endoplasmic reticulum (ER) stress pathway and chemoradiation responses in Chinese NPC patients. A total of 150 patients with histopathologically conformed NPC and treated with concurrent chemoradiotherapy were enrolled. Genotypes in ER stress pathway genes, including VCP (valosin-containing protein) rs2074549, HSP90B1 rs17034943, CANX (calnexin) rs7566, HSPA5 [heat shock protein family A (Hsp70) member 5] rs430397, CALCR (calcitonin receptor) rs2528521, and XBP1 (X-box binding protein 1) rs2269577 were analyzed by Sequenom MassARRAY system. The short-term effects of primary tumor and lymph node after radiotherapy were assessed based on the Response Evaluation Criteria in Solid Tumors (RECIST) of WHO. And acute radiation-induced toxic reactions were evaluated according to the Radiation Therapy Oncology Group or European Organization for Research and Treatment of Cancer (RTOG/EORTC). The effects of gene polymorphisms on clinical outcomes of chemoradiotherapy were assessed by chi-square test, univariate and multivariate logistic regression analyses. We found that CT and CT+CC genotypes of CANX rs7566 was significantly correlated with primary tumor treatment efficacy at 3 months after chemoradiotherapy and with occurrence of radiation-induced myelosuppression in Chinese NPC patients. CT and CT+CC genotypes of CALCR rs2528521 were significantly correlated with cervical lymph node efficacy at 3 months after chemoradiotherapy. And CC and CT+CC genotypes of VCP rs2074549 were significantly associated with occurrence of myelosuppression. In conclusion, SNPs of VCP rs2074549, CANX rs7566 and CALCR rs2528521 in ER stress pathway genes may serve as predictors for clinical outcomes of chemoradiotherapy in Chinese NPC patients.</description><identifier>ISSN: 1671-4083</identifier><identifier>EISSN: 1745-7254</identifier><identifier>DOI: 10.1038/aps.2016.148</identifier><identifier>PMID: 28216622</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenosine Triphosphatases - genetics ; Adult ; Asian Continental Ancestry Group ; Biomedical and Life Sciences ; Biomedicine ; Calnexin - genetics ; Carcinoma - metabolism ; Carcinoma - therapy ; Cell Cycle Proteins - genetics ; Chemoradiotherapy ; Endoplasmic Reticulum Stress - genetics ; Female ; Humans ; Immunology ; Internal Medicine ; Male ; Medical Microbiology ; Middle Aged ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms - metabolism ; Nasopharyngeal Neoplasms - therapy ; Original ; original-article ; Pharmacology/Toxicology ; Polymorphism, Genetic ; Receptors, Calcitonin - genetics ; Signal Transduction ; Vaccine ; Valosin Containing Protein</subject><ispartof>Acta pharmacologica Sinica, 2017-04, Vol.38 (4), p.571-580</ispartof><rights>CPS and SIMM 2017</rights><rights>Copyright Nature Publishing Group Apr 2017</rights><rights>Copyright © 2017 CPS and SIMM 2017 CPS and SIMM</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-d29ba5849a4a15d5cf2107481b6d981cce409f28f4d8744b29c66973b3888cff3</citedby><cites>FETCH-LOGICAL-c483t-d29ba5849a4a15d5cf2107481b6d981cce409f28f4d8744b29c66973b3888cff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386314/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386314/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28216622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Xiao-bin</creatorcontrib><creatorcontrib>Ma, Wan-le</creatorcontrib><creatorcontrib>Liu, Li-juan</creatorcontrib><creatorcontrib>Huang, Yu-ling</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Huang, Li-hua</creatorcontrib><creatorcontrib>Peng, Xiang-dong</creatorcontrib><creatorcontrib>Yin, Ji-ye</creatorcontrib><creatorcontrib>Li, Jin-gao</creatorcontrib><creatorcontrib>Chen, Shao-jun</creatorcontrib><creatorcontrib>Yang, Guo-ping</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Guo, Cheng-xian</creatorcontrib><title>Effects of gene polymorphisms in the endoplasmic reticulum stress pathway on clinical outcomes of chemoradiotherapy in Chinese patients with nasopharyngeal carcinoma</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacol Sin</addtitle><addtitle>Acta Pharmacol Sin</addtitle><description>There is considerable inter-individual variabil¬ity in chemoradiotherapy responses in nasopharyngeal carcinoma (NPC) patients receiv¬ing the same or similar treatment protocols. In this study we evaluated the association between the gene polymorphisms in endoplasmic reticulum (ER) stress pathway and chemoradiation responses in Chinese NPC patients. A total of 150 patients with histopathologically conformed NPC and treated with concurrent chemoradiotherapy were enrolled. Genotypes in ER stress pathway genes, including VCP (valosin-containing protein) rs2074549, HSP90B1 rs17034943, CANX (calnexin) rs7566, HSPA5 [heat shock protein family A (Hsp70) member 5] rs430397, CALCR (calcitonin receptor) rs2528521, and XBP1 (X-box binding protein 1) rs2269577 were analyzed by Sequenom MassARRAY system. The short-term effects of primary tumor and lymph node after radiotherapy were assessed based on the Response Evaluation Criteria in Solid Tumors (RECIST) of WHO. And acute radiation-induced toxic reactions were evaluated according to the Radiation Therapy Oncology Group or European Organization for Research and Treatment of Cancer (RTOG/EORTC). The effects of gene polymorphisms on clinical outcomes of chemoradiotherapy were assessed by chi-square test, univariate and multivariate logistic regression analyses. We found that CT and CT+CC genotypes of CANX rs7566 was significantly correlated with primary tumor treatment efficacy at 3 months after chemoradiotherapy and with occurrence of radiation-induced myelosuppression in Chinese NPC patients. CT and CT+CC genotypes of CALCR rs2528521 were significantly correlated with cervical lymph node efficacy at 3 months after chemoradiotherapy. And CC and CT+CC genotypes of VCP rs2074549 were significantly associated with occurrence of myelosuppression. In conclusion, SNPs of VCP rs2074549, CANX rs7566 and CALCR rs2528521 in ER stress pathway genes may serve as predictors for clinical outcomes of chemoradiotherapy in Chinese NPC patients.</description><subject>Adenosine Triphosphatases - genetics</subject><subject>Adult</subject><subject>Asian Continental Ancestry Group</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calnexin - genetics</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - therapy</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Chemoradiotherapy</subject><subject>Endoplasmic Reticulum Stress - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Middle Aged</subject><subject>Nasopharyngeal Carcinoma</subject><subject>Nasopharyngeal Neoplasms - metabolism</subject><subject>Nasopharyngeal Neoplasms - therapy</subject><subject>Original</subject><subject>original-article</subject><subject>Pharmacology/Toxicology</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Calcitonin - genetics</subject><subject>Signal Transduction</subject><subject>Vaccine</subject><subject>Valosin Containing 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of gene polymorphisms in the endoplasmic reticulum stress pathway on clinical outcomes of chemoradiotherapy in Chinese patients with nasopharyngeal carcinoma</title><author>Guo, Xiao-bin ; Ma, Wan-le ; Liu, Li-juan ; Huang, Yu-ling ; Wang, Jing ; Huang, Li-hua ; Peng, Xiang-dong ; Yin, Ji-ye ; Li, Jin-gao ; Chen, Shao-jun ; Yang, Guo-ping ; Wang, Hui ; Guo, Cheng-xian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-d29ba5849a4a15d5cf2107481b6d981cce409f28f4d8744b29c66973b3888cff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenosine Triphosphatases - genetics</topic><topic>Adult</topic><topic>Asian Continental Ancestry Group</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calnexin - genetics</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - therapy</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Chemoradiotherapy</topic><topic>Endoplasmic Reticulum Stress - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Middle Aged</topic><topic>Nasopharyngeal Carcinoma</topic><topic>Nasopharyngeal Neoplasms - metabolism</topic><topic>Nasopharyngeal Neoplasms - therapy</topic><topic>Original</topic><topic>original-article</topic><topic>Pharmacology/Toxicology</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Calcitonin - genetics</topic><topic>Signal Transduction</topic><topic>Vaccine</topic><topic>Valosin Containing Protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Xiao-bin</creatorcontrib><creatorcontrib>Ma, Wan-le</creatorcontrib><creatorcontrib>Liu, Li-juan</creatorcontrib><creatorcontrib>Huang, Yu-ling</creatorcontrib><creatorcontrib>Wang, 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China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Xiao-bin</au><au>Ma, Wan-le</au><au>Liu, Li-juan</au><au>Huang, Yu-ling</au><au>Wang, Jing</au><au>Huang, Li-hua</au><au>Peng, Xiang-dong</au><au>Yin, Ji-ye</au><au>Li, Jin-gao</au><au>Chen, Shao-jun</au><au>Yang, Guo-ping</au><au>Wang, Hui</au><au>Guo, Cheng-xian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of gene polymorphisms in the endoplasmic reticulum stress pathway on clinical outcomes of chemoradiotherapy in Chinese patients with nasopharyngeal carcinoma</atitle><jtitle>Acta pharmacologica Sinica</jtitle><stitle>Acta Pharmacol Sin</stitle><addtitle>Acta Pharmacol Sin</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>38</volume><issue>4</issue><spage>571</spage><epage>580</epage><pages>571-580</pages><issn>1671-4083</issn><eissn>1745-7254</eissn><abstract>There is considerable inter-individual variabil¬ity in chemoradiotherapy responses in nasopharyngeal carcinoma (NPC) patients receiv¬ing the same or similar treatment protocols. In this study we evaluated the association between the gene polymorphisms in endoplasmic reticulum (ER) stress pathway and chemoradiation responses in Chinese NPC patients. A total of 150 patients with histopathologically conformed NPC and treated with concurrent chemoradiotherapy were enrolled. Genotypes in ER stress pathway genes, including VCP (valosin-containing protein) rs2074549, HSP90B1 rs17034943, CANX (calnexin) rs7566, HSPA5 [heat shock protein family A (Hsp70) member 5] rs430397, CALCR (calcitonin receptor) rs2528521, and XBP1 (X-box binding protein 1) rs2269577 were analyzed by Sequenom MassARRAY system. The short-term effects of primary tumor and lymph node after radiotherapy were assessed based on the Response Evaluation Criteria in Solid Tumors (RECIST) of WHO. And acute radiation-induced toxic reactions were evaluated according to the Radiation Therapy Oncology Group or European Organization for Research and Treatment of Cancer (RTOG/EORTC). The effects of gene polymorphisms on clinical outcomes of chemoradiotherapy were assessed by chi-square test, univariate and multivariate logistic regression analyses. We found that CT and CT+CC genotypes of CANX rs7566 was significantly correlated with primary tumor treatment efficacy at 3 months after chemoradiotherapy and with occurrence of radiation-induced myelosuppression in Chinese NPC patients. CT and CT+CC genotypes of CALCR rs2528521 were significantly correlated with cervical lymph node efficacy at 3 months after chemoradiotherapy. And CC and CT+CC genotypes of VCP rs2074549 were significantly associated with occurrence of myelosuppression. In conclusion, SNPs of VCP rs2074549, CANX rs7566 and CALCR rs2528521 in ER stress pathway genes may serve as predictors for clinical outcomes of chemoradiotherapy in Chinese NPC patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28216622</pmid><doi>10.1038/aps.2016.148</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenosine Triphosphatases - genetics Adult Asian Continental Ancestry Group Biomedical and Life Sciences Biomedicine Calnexin - genetics Carcinoma - metabolism Carcinoma - therapy Cell Cycle Proteins - genetics Chemoradiotherapy Endoplasmic Reticulum Stress - genetics Female Humans Immunology Internal Medicine Male Medical Microbiology Middle Aged Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - therapy Original original-article Pharmacology/Toxicology Polymorphism, Genetic Receptors, Calcitonin - genetics Signal Transduction Vaccine Valosin Containing Protein |
| title | Effects of gene polymorphisms in the endoplasmic reticulum stress pathway on clinical outcomes of chemoradiotherapy in Chinese patients with nasopharyngeal carcinoma |
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