The Role of Estrogen in Cardiac Metabolism and Diastolic Function
Heart failure with preserved ejection fraction (HFpEF) has similar prevalence and prognosis as HF with reduced EF, but there is no approved treatment for HFpEF. HFpEF is common in postmenopausal women, which suggests that the absence of estrogen (E2) plays a role in its pathophysiology. With the cou...
Gespeichert in:
| Veröffentlicht in: | Methodist DeBakey cardiovascular journal 2017-01, Vol.13 (1), p.4-8 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8 |
|---|---|
| container_issue | 1 |
| container_start_page | 4 |
| container_title | Methodist DeBakey cardiovascular journal |
| container_volume | 13 |
| creator | Li, Shumin Gupte, Anisha A |
| description | Heart failure with preserved ejection fraction (HFpEF) has similar prevalence and prognosis as HF with reduced EF, but there is no approved treatment for HFpEF. HFpEF is common in postmenopausal women, which suggests that the absence of estrogen (E2) plays a role in its pathophysiology. With the country's growing elderly population, the prevalence of HFpEF is rapidly increasing. This has triggered a renewed urgency in finding novel approaches to preventing and slowing the progression of HFpEF. In this review, we address the role of E2 in left ventricular diastolic function and how it impacts women with HFpEF as well as animal models. We also discuss the primary potential mechanisms that represent critical nodes in the mechanistic pathways of HFpEF and how new treatments could be developed to target those mechanisms. |
| doi_str_mv | 10.14797/mdcj-13-1-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5385797</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1888967117</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2994-9f5de4b46fa7c4c413205ceb0c9490c3c4a2a6a7da4a6aa001734954fffc27fe3</originalsourceid><addsrcrecordid>eNpVkM1LAzEQxYMoVmpvniVHD64mm-xmcxFKbVWoCFLPIZtN2pTdpCa7gv-9W_uBzmVmmMd7ww-AK4zuMGWc3TeVWieYJDihJ-ACc8qSHKPi9DAjTgdgFOMa9UUYZjk6B4O0oJhkLLsA48VKw3dfa-gNnMY2-KV20Do4kaGyUsFX3crS1zY2ULoKPloZ235VcNY51VrvLsGZkXXUo30fgo_ZdDF5TuZvTy-T8TxRKec04SarNC1pbiRTVPX5KcqULpHilCNFFJWpzCWrJO2bRAgzQnlGjTEqZUaTIXjY-W66stGV0q4NshabYBsZvoWXVvy_OLsSS_8lMlJkPare4GZvEPxnp2MrGhuVrmvptO-iwEVR8JxhvJXe7qQq-BiDNscYjMQveLEFLzARWNBefv33taP4gJn8AFCAf20</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1888967117</pqid></control><display><type>article</type><title>The Role of Estrogen in Cardiac Metabolism and Diastolic Function</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Li, Shumin ; Gupte, Anisha A</creator><creatorcontrib>Li, Shumin ; Gupte, Anisha A</creatorcontrib><description>Heart failure with preserved ejection fraction (HFpEF) has similar prevalence and prognosis as HF with reduced EF, but there is no approved treatment for HFpEF. HFpEF is common in postmenopausal women, which suggests that the absence of estrogen (E2) plays a role in its pathophysiology. With the country's growing elderly population, the prevalence of HFpEF is rapidly increasing. This has triggered a renewed urgency in finding novel approaches to preventing and slowing the progression of HFpEF. In this review, we address the role of E2 in left ventricular diastolic function and how it impacts women with HFpEF as well as animal models. We also discuss the primary potential mechanisms that represent critical nodes in the mechanistic pathways of HFpEF and how new treatments could be developed to target those mechanisms.</description><identifier>ISSN: 1947-6094</identifier><identifier>EISSN: 1947-6108</identifier><identifier>DOI: 10.14797/mdcj-13-1-4</identifier><identifier>PMID: 28413575</identifier><language>eng</language><publisher>United States: The Methodist Hospital Houston, Texas</publisher><subject>Animals ; Diastole ; Energy Metabolism - drug effects ; Estrogen Replacement Therapy ; Estrogens - metabolism ; Estrogens - therapeutic use ; Female ; Heart Failure - drug therapy ; Heart Failure - epidemiology ; Heart Failure - metabolism ; Heart Failure - physiopathology ; Humans ; Male ; Myocardium - metabolism ; Postmenopause - metabolism ; Prevalence ; Risk Factors ; Sex Factors ; Stroke Volume ; Ventricular Dysfunction, Left - drug therapy ; Ventricular Dysfunction, Left - epidemiology ; Ventricular Dysfunction, Left - metabolism ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left - drug effects</subject><ispartof>Methodist DeBakey cardiovascular journal, 2017-01, Vol.13 (1), p.4-8</ispartof><rights>2017 The Methodist Hospital Houston, Texas 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2994-9f5de4b46fa7c4c413205ceb0c9490c3c4a2a6a7da4a6aa001734954fffc27fe3</citedby><cites>FETCH-LOGICAL-c2994-9f5de4b46fa7c4c413205ceb0c9490c3c4a2a6a7da4a6aa001734954fffc27fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385797/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385797/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28413575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Shumin</creatorcontrib><creatorcontrib>Gupte, Anisha A</creatorcontrib><title>The Role of Estrogen in Cardiac Metabolism and Diastolic Function</title><title>Methodist DeBakey cardiovascular journal</title><addtitle>Methodist Debakey Cardiovasc J</addtitle><description>Heart failure with preserved ejection fraction (HFpEF) has similar prevalence and prognosis as HF with reduced EF, but there is no approved treatment for HFpEF. HFpEF is common in postmenopausal women, which suggests that the absence of estrogen (E2) plays a role in its pathophysiology. With the country's growing elderly population, the prevalence of HFpEF is rapidly increasing. This has triggered a renewed urgency in finding novel approaches to preventing and slowing the progression of HFpEF. In this review, we address the role of E2 in left ventricular diastolic function and how it impacts women with HFpEF as well as animal models. We also discuss the primary potential mechanisms that represent critical nodes in the mechanistic pathways of HFpEF and how new treatments could be developed to target those mechanisms.</description><subject>Animals</subject><subject>Diastole</subject><subject>Energy Metabolism - drug effects</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens - metabolism</subject><subject>Estrogens - therapeutic use</subject><subject>Female</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - epidemiology</subject><subject>Heart Failure - metabolism</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Myocardium - metabolism</subject><subject>Postmenopause - metabolism</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Stroke Volume</subject><subject>Ventricular Dysfunction, Left - drug therapy</subject><subject>Ventricular Dysfunction, Left - epidemiology</subject><subject>Ventricular Dysfunction, Left - metabolism</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function, Left - drug effects</subject><issn>1947-6094</issn><issn>1947-6108</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1LAzEQxYMoVmpvniVHD64mm-xmcxFKbVWoCFLPIZtN2pTdpCa7gv-9W_uBzmVmmMd7ww-AK4zuMGWc3TeVWieYJDihJ-ACc8qSHKPi9DAjTgdgFOMa9UUYZjk6B4O0oJhkLLsA48VKw3dfa-gNnMY2-KV20Do4kaGyUsFX3crS1zY2ULoKPloZ235VcNY51VrvLsGZkXXUo30fgo_ZdDF5TuZvTy-T8TxRKec04SarNC1pbiRTVPX5KcqULpHilCNFFJWpzCWrJO2bRAgzQnlGjTEqZUaTIXjY-W66stGV0q4NshabYBsZvoWXVvy_OLsSS_8lMlJkPare4GZvEPxnp2MrGhuVrmvptO-iwEVR8JxhvJXe7qQq-BiDNscYjMQveLEFLzARWNBefv33taP4gJn8AFCAf20</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Li, Shumin</creator><creator>Gupte, Anisha A</creator><general>The Methodist Hospital Houston, Texas</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201701</creationdate><title>The Role of Estrogen in Cardiac Metabolism and Diastolic Function</title><author>Li, Shumin ; Gupte, Anisha A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2994-9f5de4b46fa7c4c413205ceb0c9490c3c4a2a6a7da4a6aa001734954fffc27fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Diastole</topic><topic>Energy Metabolism - drug effects</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens - metabolism</topic><topic>Estrogens - therapeutic use</topic><topic>Female</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - epidemiology</topic><topic>Heart Failure - metabolism</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Myocardium - metabolism</topic><topic>Postmenopause - metabolism</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Stroke Volume</topic><topic>Ventricular Dysfunction, Left - drug therapy</topic><topic>Ventricular Dysfunction, Left - epidemiology</topic><topic>Ventricular Dysfunction, Left - metabolism</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Function, Left - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shumin</creatorcontrib><creatorcontrib>Gupte, Anisha A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Methodist DeBakey cardiovascular journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shumin</au><au>Gupte, Anisha A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Estrogen in Cardiac Metabolism and Diastolic Function</atitle><jtitle>Methodist DeBakey cardiovascular journal</jtitle><addtitle>Methodist Debakey Cardiovasc J</addtitle><date>2017-01</date><risdate>2017</risdate><volume>13</volume><issue>1</issue><spage>4</spage><epage>8</epage><pages>4-8</pages><issn>1947-6094</issn><eissn>1947-6108</eissn><abstract>Heart failure with preserved ejection fraction (HFpEF) has similar prevalence and prognosis as HF with reduced EF, but there is no approved treatment for HFpEF. HFpEF is common in postmenopausal women, which suggests that the absence of estrogen (E2) plays a role in its pathophysiology. With the country's growing elderly population, the prevalence of HFpEF is rapidly increasing. This has triggered a renewed urgency in finding novel approaches to preventing and slowing the progression of HFpEF. In this review, we address the role of E2 in left ventricular diastolic function and how it impacts women with HFpEF as well as animal models. We also discuss the primary potential mechanisms that represent critical nodes in the mechanistic pathways of HFpEF and how new treatments could be developed to target those mechanisms.</abstract><cop>United States</cop><pub>The Methodist Hospital Houston, Texas</pub><pmid>28413575</pmid><doi>10.14797/mdcj-13-1-4</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1947-6094 |
| ispartof | Methodist DeBakey cardiovascular journal, 2017-01, Vol.13 (1), p.4-8 |
| issn | 1947-6094 1947-6108 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5385797 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Diastole Energy Metabolism - drug effects Estrogen Replacement Therapy Estrogens - metabolism Estrogens - therapeutic use Female Heart Failure - drug therapy Heart Failure - epidemiology Heart Failure - metabolism Heart Failure - physiopathology Humans Male Myocardium - metabolism Postmenopause - metabolism Prevalence Risk Factors Sex Factors Stroke Volume Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - epidemiology Ventricular Dysfunction, Left - metabolism Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - drug effects |
| title | The Role of Estrogen in Cardiac Metabolism and Diastolic Function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T17%3A32%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Role%20of%20Estrogen%20in%20Cardiac%20Metabolism%20and%20Diastolic%20Function&rft.jtitle=Methodist%20DeBakey%20cardiovascular%20journal&rft.au=Li,%20Shumin&rft.date=2017-01&rft.volume=13&rft.issue=1&rft.spage=4&rft.epage=8&rft.pages=4-8&rft.issn=1947-6094&rft.eissn=1947-6108&rft_id=info:doi/10.14797/mdcj-13-1-4&rft_dat=%3Cproquest_pubme%3E1888967117%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1888967117&rft_id=info:pmid/28413575&rfr_iscdi=true |