Visualization of aging-associated chromatin alterations with an engineered TALE system

Visualization of specific genomic loci in live cells is a prerequisite for the investigation of dynamic changes in chro- matin architecture during diverse biological processes, such as cellular aging. However, current precision genomic imaging methods are hampered by the lack of fluorescent probes w...

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Veröffentlicht in:	Cell research 2017-04, Vol.27 (4), p.483-504
Hauptverfasser:	Ren, Ruotong, Deng, Liping, Xue, Yanhong, Suzuki, Keiichiro, Zhang, Weiqi, Yu, Yang, Wu, Jun, Sun, Liang, Gong, Xiaojun, Luan, Huiqin, Yang, Fan, Ju, Zhenyu, Ren, Xiaoqing, Wang, Si, Tang, Hong, Geng, Lingling, Zhang, Weizhou, Li, Jian, Qiao, Jie, Xu, Tao, Qu, Jing, Liu, Guang-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/7 631/337/100/102 631/553/1886 631/80 Aging Aging - genetics Animals Cell Biology Cell Differentiation Cell Line Cellular Senescence Centromere - metabolism Chromatin - genetics CRISPR-Associated Proteins - metabolism DNA, Ribosomal - metabolism DNA重复序列 Genetic Engineering Genetic Loci Genomics Humans Imaging, Three-Dimensional Life Sciences Mesenchymal Stem Cells - cytology Mice, Inbred C57BL Mitosis Nucleolus Organizer Region - genetics Oocytes - cytology Original original-article Repetitive Sequences, Nucleic Acid - genetics RNA, Guide, CRISPR-Cas Systems Telomerase - metabolism Telomere - metabolism Thioredoxins - metabolism Transcription Activator-Like Effector Nucleases - metabolism 可视化工程成像方法故事染色质硫氧还蛋白系统
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