Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line

Somatic mutations in PIK3CA are frequently found in a number of human cancers, including breast cancer, altering cellular physiology and tumour sensitivity to chemotherapy. This renders PIK3CA an attractive molecular target for early detection and personalised therapy. Using 1 H Nuclear Magnetic Res...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2017-04, Vol.7 (1), p.46079-46079, Article 46079
Hauptverfasser:	Lau, Chung-Ho E., Tredwell, Gregory D., Ellis, James K., Lam, Eric W.-F., Keun, Hector C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/2327 631/92/320 Breast cancer Breast Neoplasms - pathology Carcinogenesis - metabolism Carcinogenesis - pathology Cell Line, Tumor Chemotherapy Citric Acid Cycle Class I Phosphatidylinositol 3-Kinases - metabolism Epithelial Cells - metabolism Epithelial Cells - pathology Female Gas chromatography Genetic transformation Glutamic Acid - metabolism Glutamine Glycerylphosphorylcholine - metabolism Humanities and Social Sciences Humans Lipids - analysis Lipogenesis Magnetic resonance spectroscopy Metabolic pathways Metabolism Metabolome Metabolomics Models, Biological multidisciplinary Mutation - genetics NMR Nuclear magnetic resonance Proton Magnetic Resonance Spectroscopy Pyruvates - metabolism Pyruvic acid Science Spectroscopy Stable isotopes Tracers Tricarboxylic acid cycle Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!