Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study

BACKGROUND Merkel cell carcinoma (MCC) is an aggressive skin cancer with a recurrence rate of >40%. Of the 2000 MCC cases per year in the United States, most are caused by the Merkel cell polyomavirus (MCPyV). Antibodies to MCPyV oncoprotein (T‐antigens) have been correlated with MCC tumor burden...

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Veröffentlicht in:	Cancer 2017-04, Vol.123 (8), p.1464-1474
Hauptverfasser:	Paulson, Kelly G., Lewis, Christopher W., Redman, Mary W., Simonson, William T., Lisberg, Aaron, Ritter, Deborah, Morishima, Chihiro, Hutchinson, Kathleen, Mudgistratova, Lola, Blom, Astrid, Iyer, Jayasri, Moshiri, Ata S., Tarabadkar, Erica S., Carter, Joseph J., Bhatia, Shailender, Kawasumi, Masaoki, Galloway, Denise A., Wener, Mark H., Nghiem, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Antigens Biomarkers Cancer Carcinoma, Merkel Cell - diagnosis Carcinoma, Merkel Cell - epidemiology Carcinoma, Merkel Cell - etiology Carcinoma, Merkel Cell - mortality Falling Female Health risks Humans Immunoglobulins Immunosuppression Male Merkel cell carcinoma (MCC) Merkel cell polyomavirus (MCPyV) Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Oncogene Proteins, Viral - immunology Oncology oncoprotein Oncoproteins Patients Polyomaviridae Population Surveillance Prospective Studies Reproducibility of Results Risk Seroepidemiologic Studies serology Skin cancer T antigen Tumor markers Tumor Virus Infections - complications Tumor Virus Infections - immunology Tumor Virus Infections - virology
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