The expansion of endoscopic submucosal dissection in France: A prospective nationwide survey
Introduction Early reports of endoscopic submucosal dissection (ESD) in Europe suggested high complication rates and disappointing outcomes compared to publications from Japan. Since 2008, we have been conducting a nationwide survey to monitor the outcomes and complications of ESD over time. Materia...
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| creator | Barret, Maximilien Lepilliez, Vincent Coumaros, Dimitri Chaussade, Stanislas Leblanc, Sarah Ponchon, Thierry Fumex, Fabien Chabrun, Edouard Bauret, Paul Cellier, Christophe Coron, Emmanuel Bichard, Philippe Bulois, Philippe Charachon, Antoine Rahmi, Gabriel Bellon, Serge Lerhun, Marc Arpurt, Jean-Pierre Koch, Stéphane Napoleon, Bertrand Vaillant, Eric Esch, Anouk Farhat, Said Robin, Francoise Kaddour, Nadira Prat, Frédéric |
| description | Introduction
Early reports of endoscopic submucosal dissection (ESD) in Europe suggested high complication rates and disappointing outcomes compared to publications from Japan. Since 2008, we have been conducting a nationwide survey to monitor the outcomes and complications of ESD over time.
Material and methods
All consecutive ESD cases from 14 centers in France were prospectively included in the database. Demographic, procedural, outcome and follow-up data were recorded. The results obtained over three years were compared to previously published data covering the 2008–2010 period.
Results
Between November 2010 and June 2013, 319 ESD cases performed in 314 patients (62% male, mean (±SD) age 65.4 ± 12) were analyzed and compared to 188 ESD cases in 188 patients (61% male, mean (±SD) age 64.6 ± 13) performed between January 2008 and October 2010. The mean (±SD) lesion size was 39 ± 12 mm in 2010–2013 vs 32.1 ± 21 for 2008–2010 (p = 0.004). En bloc resection improved from 77.1% to 91.7% (p |
| doi_str_mv | 10.1177/2050640616644392 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5384549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_2050640616644392</sage_id><sourcerecordid>1887420825</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4843-ddcaacbc63b41c32ea0be38d1bc7c72cc1c055dccfc63a95247b4f44ef13fc963</originalsourceid><addsrcrecordid>eNqFUU1rFDEYDqLYUnv3JDl6Gc33ZDwItXRboeClvQkh8847bcpsMk52tu6_N8PWpQpiLgl5Pt4neQh5y9kHzuv6o2CaGcUMN0Yp2YgX5Hi5qozi6uXhzMwROc35gZVlrRJCvSZHwiqmpeDH5PvNPVL8OfqYQ4o09RRjlzKkMQDNc7ueIWU_0C7kjLBZOCHS1eQj4Cd6Rscp5XEBtkijX_DH0GFRTlvcvSGvej9kPH3aT8jt6uLm_Kq6_nb59fzsugJllay6DryHFoxsFQcp0LMWpe14CzXUAoAD07oD6AvFN1qoulW9Uthz2UNj5An5vPcdS2DsAONm8oMbp7D2084lH9yfSAz37i5tnZZWadUUg_dPBlP6MWPeuHXIgMPgI6Y5O25trQSzQhcq21OhvDxP2B_GcOaWXtzfvRTJu-fxDoLfLRRCsyc8hgF3_zV0txeX4suKMaNl0VZ7bfZ36B7SPMXy1f8O8wsXjag5</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1887420825</pqid></control><display><type>article</type><title>The expansion of endoscopic submucosal dissection in France: A prospective nationwide survey</title><source>Wiley Online Library (Open Access Collection)</source><creator>Barret, Maximilien ; Lepilliez, Vincent ; Coumaros, Dimitri ; Chaussade, Stanislas ; Leblanc, Sarah ; Ponchon, Thierry ; Fumex, Fabien ; Chabrun, Edouard ; Bauret, Paul ; Cellier, Christophe ; Coron, Emmanuel ; Bichard, Philippe ; Bulois, Philippe ; Charachon, Antoine ; Rahmi, Gabriel ; Bellon, Serge ; Lerhun, Marc ; Arpurt, Jean-Pierre ; Koch, Stéphane ; Napoleon, Bertrand ; Vaillant, Eric ; Esch, Anouk ; Farhat, Said ; Robin, Francoise ; Kaddour, Nadira ; Prat, Frédéric</creator><creatorcontrib>Barret, Maximilien ; Lepilliez, Vincent ; Coumaros, Dimitri ; Chaussade, Stanislas ; Leblanc, Sarah ; Ponchon, Thierry ; Fumex, Fabien ; Chabrun, Edouard ; Bauret, Paul ; Cellier, Christophe ; Coron, Emmanuel ; Bichard, Philippe ; Bulois, Philippe ; Charachon, Antoine ; Rahmi, Gabriel ; Bellon, Serge ; Lerhun, Marc ; Arpurt, Jean-Pierre ; Koch, Stéphane ; Napoleon, Bertrand ; Vaillant, Eric ; Esch, Anouk ; Farhat, Said ; Robin, Francoise ; Kaddour, Nadira ; Prat, Frédéric ; Société Française d’Endoscopie Digestive (SFED) ; for the Société Française d’Endoscopie Digestive (SFED)</creatorcontrib><description>Introduction
Early reports of endoscopic submucosal dissection (ESD) in Europe suggested high complication rates and disappointing outcomes compared to publications from Japan. Since 2008, we have been conducting a nationwide survey to monitor the outcomes and complications of ESD over time.
Material and methods
All consecutive ESD cases from 14 centers in France were prospectively included in the database. Demographic, procedural, outcome and follow-up data were recorded. The results obtained over three years were compared to previously published data covering the 2008–2010 period.
Results
Between November 2010 and June 2013, 319 ESD cases performed in 314 patients (62% male, mean (±SD) age 65.4 ± 12) were analyzed and compared to 188 ESD cases in 188 patients (61% male, mean (±SD) age 64.6 ± 13) performed between January 2008 and October 2010. The mean (±SD) lesion size was 39 ± 12 mm in 2010–2013 vs 32.1 ± 21 for 2008–2010 (p = 0.004). En bloc resection improved from 77.1% to 91.7% (p < 0.0001) while R0 en bloc resection remained stable from 72.9% to 71.9% (p = 0.8) over time. Complication rate dropped from 29.2% between 2008 and 2010 to 14.1% between 2010 and 2013 (p < 0.0001), with bleeding decreasing from 11.2% to 4.7% (p = 0.01) and perforations from 18.1% to 8.1% (p = 0.002) over time. No procedure-related mortality was recorded.
Conclusions
In this multicenter study, ESD achieved high rates of en bloc resection with a significant trend toward better outcomes over time. Improvements in lesion delineation and characterization are still needed to increase R0 resection rates.</description><identifier>ISSN: 2050-6406</identifier><identifier>EISSN: 2050-6414</identifier><identifier>DOI: 10.1177/2050640616644392</identifier><identifier>PMID: 28405321</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>early neoplasm ; endoscopic resection ; Endoscopic submucosal dissection ; intramucosal cancer ; Original</subject><ispartof>United European gastroenterology journal, 2017-02, Vol.5 (1), p.45-53</ispartof><rights>Author(s) 2016</rights><rights>2017 The Authors. UEG Journal published by Wiley Periodicals LLC. on behalf of United European Gastroenterology</rights><rights>Author(s) 2016 2016 United European Gastroenterology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4843-ddcaacbc63b41c32ea0be38d1bc7c72cc1c055dccfc63a95247b4f44ef13fc963</citedby><cites>FETCH-LOGICAL-c4843-ddcaacbc63b41c32ea0be38d1bc7c72cc1c055dccfc63a95247b4f44ef13fc963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384549/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384549/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1177%2F2050640616644392$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28405321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barret, Maximilien</creatorcontrib><creatorcontrib>Lepilliez, Vincent</creatorcontrib><creatorcontrib>Coumaros, Dimitri</creatorcontrib><creatorcontrib>Chaussade, Stanislas</creatorcontrib><creatorcontrib>Leblanc, Sarah</creatorcontrib><creatorcontrib>Ponchon, Thierry</creatorcontrib><creatorcontrib>Fumex, Fabien</creatorcontrib><creatorcontrib>Chabrun, Edouard</creatorcontrib><creatorcontrib>Bauret, Paul</creatorcontrib><creatorcontrib>Cellier, Christophe</creatorcontrib><creatorcontrib>Coron, Emmanuel</creatorcontrib><creatorcontrib>Bichard, Philippe</creatorcontrib><creatorcontrib>Bulois, Philippe</creatorcontrib><creatorcontrib>Charachon, Antoine</creatorcontrib><creatorcontrib>Rahmi, Gabriel</creatorcontrib><creatorcontrib>Bellon, Serge</creatorcontrib><creatorcontrib>Lerhun, Marc</creatorcontrib><creatorcontrib>Arpurt, Jean-Pierre</creatorcontrib><creatorcontrib>Koch, Stéphane</creatorcontrib><creatorcontrib>Napoleon, Bertrand</creatorcontrib><creatorcontrib>Vaillant, Eric</creatorcontrib><creatorcontrib>Esch, Anouk</creatorcontrib><creatorcontrib>Farhat, Said</creatorcontrib><creatorcontrib>Robin, Francoise</creatorcontrib><creatorcontrib>Kaddour, Nadira</creatorcontrib><creatorcontrib>Prat, Frédéric</creatorcontrib><creatorcontrib>Société Française d’Endoscopie Digestive (SFED)</creatorcontrib><creatorcontrib>for the Société Française d’Endoscopie Digestive (SFED)</creatorcontrib><title>The expansion of endoscopic submucosal dissection in France: A prospective nationwide survey</title><title>United European gastroenterology journal</title><addtitle>United European Gastroenterol J</addtitle><description>Introduction
Early reports of endoscopic submucosal dissection (ESD) in Europe suggested high complication rates and disappointing outcomes compared to publications from Japan. Since 2008, we have been conducting a nationwide survey to monitor the outcomes and complications of ESD over time.
Material and methods
All consecutive ESD cases from 14 centers in France were prospectively included in the database. Demographic, procedural, outcome and follow-up data were recorded. The results obtained over three years were compared to previously published data covering the 2008–2010 period.
Results
Between November 2010 and June 2013, 319 ESD cases performed in 314 patients (62% male, mean (±SD) age 65.4 ± 12) were analyzed and compared to 188 ESD cases in 188 patients (61% male, mean (±SD) age 64.6 ± 13) performed between January 2008 and October 2010. The mean (±SD) lesion size was 39 ± 12 mm in 2010–2013 vs 32.1 ± 21 for 2008–2010 (p = 0.004). En bloc resection improved from 77.1% to 91.7% (p < 0.0001) while R0 en bloc resection remained stable from 72.9% to 71.9% (p = 0.8) over time. Complication rate dropped from 29.2% between 2008 and 2010 to 14.1% between 2010 and 2013 (p < 0.0001), with bleeding decreasing from 11.2% to 4.7% (p = 0.01) and perforations from 18.1% to 8.1% (p = 0.002) over time. No procedure-related mortality was recorded.
Conclusions
In this multicenter study, ESD achieved high rates of en bloc resection with a significant trend toward better outcomes over time. Improvements in lesion delineation and characterization are still needed to increase R0 resection rates.</description><subject>early neoplasm</subject><subject>endoscopic resection</subject><subject>Endoscopic submucosal dissection</subject><subject>intramucosal cancer</subject><subject>Original</subject><issn>2050-6406</issn><issn>2050-6414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFUU1rFDEYDqLYUnv3JDl6Gc33ZDwItXRboeClvQkh8847bcpsMk52tu6_N8PWpQpiLgl5Pt4neQh5y9kHzuv6o2CaGcUMN0Yp2YgX5Hi5qozi6uXhzMwROc35gZVlrRJCvSZHwiqmpeDH5PvNPVL8OfqYQ4o09RRjlzKkMQDNc7ueIWU_0C7kjLBZOCHS1eQj4Cd6Rscp5XEBtkijX_DH0GFRTlvcvSGvej9kPH3aT8jt6uLm_Kq6_nb59fzsugJllay6DryHFoxsFQcp0LMWpe14CzXUAoAD07oD6AvFN1qoulW9Uthz2UNj5An5vPcdS2DsAONm8oMbp7D2084lH9yfSAz37i5tnZZWadUUg_dPBlP6MWPeuHXIgMPgI6Y5O25trQSzQhcq21OhvDxP2B_GcOaWXtzfvRTJu-fxDoLfLRRCsyc8hgF3_zV0txeX4suKMaNl0VZ7bfZ36B7SPMXy1f8O8wsXjag5</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Barret, Maximilien</creator><creator>Lepilliez, Vincent</creator><creator>Coumaros, Dimitri</creator><creator>Chaussade, Stanislas</creator><creator>Leblanc, Sarah</creator><creator>Ponchon, Thierry</creator><creator>Fumex, Fabien</creator><creator>Chabrun, Edouard</creator><creator>Bauret, Paul</creator><creator>Cellier, Christophe</creator><creator>Coron, Emmanuel</creator><creator>Bichard, Philippe</creator><creator>Bulois, Philippe</creator><creator>Charachon, Antoine</creator><creator>Rahmi, Gabriel</creator><creator>Bellon, Serge</creator><creator>Lerhun, Marc</creator><creator>Arpurt, Jean-Pierre</creator><creator>Koch, Stéphane</creator><creator>Napoleon, Bertrand</creator><creator>Vaillant, Eric</creator><creator>Esch, Anouk</creator><creator>Farhat, Said</creator><creator>Robin, Francoise</creator><creator>Kaddour, Nadira</creator><creator>Prat, Frédéric</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201702</creationdate><title>The expansion of endoscopic submucosal dissection in France: A prospective nationwide survey</title><author>Barret, Maximilien ; Lepilliez, Vincent ; Coumaros, Dimitri ; Chaussade, Stanislas ; Leblanc, Sarah ; Ponchon, Thierry ; Fumex, Fabien ; Chabrun, Edouard ; Bauret, Paul ; Cellier, Christophe ; Coron, Emmanuel ; Bichard, Philippe ; Bulois, Philippe ; Charachon, Antoine ; Rahmi, Gabriel ; Bellon, Serge ; Lerhun, Marc ; Arpurt, Jean-Pierre ; Koch, Stéphane ; Napoleon, Bertrand ; Vaillant, Eric ; Esch, Anouk ; Farhat, Said ; Robin, Francoise ; Kaddour, Nadira ; Prat, Frédéric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4843-ddcaacbc63b41c32ea0be38d1bc7c72cc1c055dccfc63a95247b4f44ef13fc963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>early neoplasm</topic><topic>endoscopic resection</topic><topic>Endoscopic submucosal dissection</topic><topic>intramucosal cancer</topic><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barret, Maximilien</creatorcontrib><creatorcontrib>Lepilliez, Vincent</creatorcontrib><creatorcontrib>Coumaros, Dimitri</creatorcontrib><creatorcontrib>Chaussade, Stanislas</creatorcontrib><creatorcontrib>Leblanc, Sarah</creatorcontrib><creatorcontrib>Ponchon, Thierry</creatorcontrib><creatorcontrib>Fumex, Fabien</creatorcontrib><creatorcontrib>Chabrun, Edouard</creatorcontrib><creatorcontrib>Bauret, Paul</creatorcontrib><creatorcontrib>Cellier, Christophe</creatorcontrib><creatorcontrib>Coron, Emmanuel</creatorcontrib><creatorcontrib>Bichard, Philippe</creatorcontrib><creatorcontrib>Bulois, Philippe</creatorcontrib><creatorcontrib>Charachon, Antoine</creatorcontrib><creatorcontrib>Rahmi, Gabriel</creatorcontrib><creatorcontrib>Bellon, Serge</creatorcontrib><creatorcontrib>Lerhun, Marc</creatorcontrib><creatorcontrib>Arpurt, Jean-Pierre</creatorcontrib><creatorcontrib>Koch, Stéphane</creatorcontrib><creatorcontrib>Napoleon, Bertrand</creatorcontrib><creatorcontrib>Vaillant, Eric</creatorcontrib><creatorcontrib>Esch, Anouk</creatorcontrib><creatorcontrib>Farhat, Said</creatorcontrib><creatorcontrib>Robin, Francoise</creatorcontrib><creatorcontrib>Kaddour, Nadira</creatorcontrib><creatorcontrib>Prat, Frédéric</creatorcontrib><creatorcontrib>Société Française d’Endoscopie Digestive (SFED)</creatorcontrib><creatorcontrib>for the Société Française d’Endoscopie Digestive (SFED)</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>United European gastroenterology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Barret, Maximilien</au><au>Lepilliez, Vincent</au><au>Coumaros, Dimitri</au><au>Chaussade, Stanislas</au><au>Leblanc, Sarah</au><au>Ponchon, Thierry</au><au>Fumex, Fabien</au><au>Chabrun, Edouard</au><au>Bauret, Paul</au><au>Cellier, Christophe</au><au>Coron, Emmanuel</au><au>Bichard, Philippe</au><au>Bulois, Philippe</au><au>Charachon, Antoine</au><au>Rahmi, Gabriel</au><au>Bellon, Serge</au><au>Lerhun, Marc</au><au>Arpurt, Jean-Pierre</au><au>Koch, Stéphane</au><au>Napoleon, Bertrand</au><au>Vaillant, Eric</au><au>Esch, Anouk</au><au>Farhat, Said</au><au>Robin, Francoise</au><au>Kaddour, Nadira</au><au>Prat, Frédéric</au><aucorp>Société Française d’Endoscopie Digestive (SFED)</aucorp><aucorp>for the Société Française d’Endoscopie Digestive (SFED)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The expansion of endoscopic submucosal dissection in France: A prospective nationwide survey</atitle><jtitle>United European gastroenterology journal</jtitle><addtitle>United European Gastroenterol J</addtitle><date>2017-02</date><risdate>2017</risdate><volume>5</volume><issue>1</issue><spage>45</spage><epage>53</epage><pages>45-53</pages><issn>2050-6406</issn><eissn>2050-6414</eissn><abstract>Introduction
Early reports of endoscopic submucosal dissection (ESD) in Europe suggested high complication rates and disappointing outcomes compared to publications from Japan. Since 2008, we have been conducting a nationwide survey to monitor the outcomes and complications of ESD over time.
Material and methods
All consecutive ESD cases from 14 centers in France were prospectively included in the database. Demographic, procedural, outcome and follow-up data were recorded. The results obtained over three years were compared to previously published data covering the 2008–2010 period.
Results
Between November 2010 and June 2013, 319 ESD cases performed in 314 patients (62% male, mean (±SD) age 65.4 ± 12) were analyzed and compared to 188 ESD cases in 188 patients (61% male, mean (±SD) age 64.6 ± 13) performed between January 2008 and October 2010. The mean (±SD) lesion size was 39 ± 12 mm in 2010–2013 vs 32.1 ± 21 for 2008–2010 (p = 0.004). En bloc resection improved from 77.1% to 91.7% (p < 0.0001) while R0 en bloc resection remained stable from 72.9% to 71.9% (p = 0.8) over time. Complication rate dropped from 29.2% between 2008 and 2010 to 14.1% between 2010 and 2013 (p < 0.0001), with bleeding decreasing from 11.2% to 4.7% (p = 0.01) and perforations from 18.1% to 8.1% (p = 0.002) over time. No procedure-related mortality was recorded.
Conclusions
In this multicenter study, ESD achieved high rates of en bloc resection with a significant trend toward better outcomes over time. Improvements in lesion delineation and characterization are still needed to increase R0 resection rates.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>28405321</pmid><doi>10.1177/2050640616644392</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2050-6406 |
| ispartof | United European gastroenterology journal, 2017-02, Vol.5 (1), p.45-53 |
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| source | Wiley Online Library (Open Access Collection) |
| subjects | early neoplasm endoscopic resection Endoscopic submucosal dissection intramucosal cancer Original |
| title | The expansion of endoscopic submucosal dissection in France: A prospective nationwide survey |
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