Discovery of new muscarinic acetylcholine receptor antagonists from Scopolia tangutica

Scopolia tangutica (S. tangutica ) is a traditional Chinese medicinal plant used for antispasmodics, anesthesia, analgesia and sedation. Its pharmacological activities are mostly associated with the antagonistic activity at muscarinic acetylcholine receptors (mAchRs) of several known alkaloids such...

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Veröffentlicht in:	Scientific reports 2017-04, Vol.7 (1), p.46067-46067, Article 46067
Hauptverfasser:	Du, Nana, Liu, Yanfang, Zhang, Xiuli, Wang, Jixia, Zhao, Jianqiang, He, Jian, Zhou, Han, Mei, Lijuan, Liang, Xinmiao
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/1435/2417 631/154/436/2387 82/16 82/58 A549 Cells Acetylcholine receptors (muscarinic) Acids Alkaloids Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Amides Amides - pharmacology Analgesia Anesthesia Animals Atropine Berries Bioassays CHO Cells Cholinergic Antagonists - chemistry Cholinergic Antagonists - pharmacology Cinnamic acid Cricetinae Cricetulus Drug Discovery HT29 Cells Humanities and Social Sciences Humans Medicinal plants multidisciplinary Muscarinic Antagonists - chemistry Muscarinic Antagonists - pharmacology Pain perception Phenotype Purification Receptor, Muscarinic M3 - antagonists & inhibitors Receptor, Muscarinic M3 - metabolism Science Scopolamine Scopolia - chemistry Tropane
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