Big differences in primary care celiac disease serological markers request in Spain
Celiac disease (CD) prevalence is increasing but the disorder remains undiagnosed. The study compares CD serology markers requested by General Practitioners (GPs) over time and geographical areas. The aim of the current research is to assess the inter-practice and temporal variability in the request...
Gespeichert in:
| Veröffentlicht in: | Biochemia Medica 2017-02, Vol.27 (1), p.231-236 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 236 |
|---|---|
| container_issue | 1 |
| container_start_page | 231 |
| container_title | Biochemia Medica |
| container_volume | 27 |
| creator | Salinas, Maria López-Garrigós, Maite Flores, Emilio Leiva-Salinas, Carlos |
| description | Celiac disease (CD) prevalence is increasing but the disorder remains undiagnosed. The study compares CD serology markers requested by General Practitioners (GPs) over time and geographical areas. The aim of the current research is to assess the inter-practice and temporal variability in the request of CD serology markers by GPs in Spain, and the differences between regions.
A cross-sectional study was conducted enrolling Spanish clinical laboratories. Primary care CD serology markers request in 2010, 2012 and 2014 from 15 autonomous communities (AACC), with more participants was reported. Test-utilization rates were calculated (tissue transglutaminase IgA antibodies (tTG-IgA) and deaminated peptide gliadine IgA antibodies (DGP-IgA) per 1000 inhabitants), and also the ratio of both tests request (DGP-IgA /tTG-IgA).
The request of tTG-IgA per 1000 inhabitants increased significantly along years (from 3.99 to 5.90 (P < 0.001)). The demand of DGP-IgA
1000 inhabitants was maintained in 2010 and 2012 (0.68 and 0.6), and decreased in 2014 (0.35) (P = 0.927). DGP-IgA /tTG-IgA diminished over time (from 0.16 to 0.06 (P = 0.548)), and in the 2014 edition, there was a significant regional difference, ranging from 0.01 to 0.57 (P < 0.001).
The variability in the request in CD serology markers emphasizes the need of inter-regional cooperation to develop strategies to optimize the use of laboratory tests. |
| doi_str_mv | 10.11613/BM.2017.025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5382849</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1886359839</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-5496fbf234029fea011b606771d4dfd7a181761d9a509960269031a4822ddef3</originalsourceid><addsrcrecordid>eNpVkUtPAjEUhRujUXzsXJtZunCw72k3JkJ8JRAXum9K5xaqwwy2YOK_twoSWfWm_e7pPfcgdE5wnxBJ2PVg3KeYVH1MxR7qEcVlWXFF93PNGC6xlvQIHaf0hrEQQlWH6IgqpmnFeQ-9DMK0qIP3EKF1kIrQFosY5jZ-Fc5GKBw0wbqMJLAJigSxa7ppcLYpMvQOMRURPlaQlj-tLwsb2lN04G2T4GxznqDX-7vX4WM5en54Gt6OSscpXZaCa-knnjKOqfZgMSETiWVVkZrXvq4sUaSSpNZWYK0lplJjRmy2RusaPDtBN2vZxWoyh9pBu4y2MZvpTWeD2X1pw8xMu08jmKKK6yxQrgVm0dn3ncb1TYoOcmnyGILhzF9uPozdr2MzDynvp7EtdKtkiFKSCZ13m9GrNepil1IEv1Un2PzGZgZj8xObybFl_OK_lS38lxP7BvA7k3c</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1886359839</pqid></control><display><type>article</type><title>Big differences in primary care celiac disease serological markers request in Spain</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Salinas, Maria ; López-Garrigós, Maite ; Flores, Emilio ; Leiva-Salinas, Carlos</creator><creatorcontrib>Salinas, Maria ; López-Garrigós, Maite ; Flores, Emilio ; Leiva-Salinas, Carlos</creatorcontrib><description>Celiac disease (CD) prevalence is increasing but the disorder remains undiagnosed. The study compares CD serology markers requested by General Practitioners (GPs) over time and geographical areas. The aim of the current research is to assess the inter-practice and temporal variability in the request of CD serology markers by GPs in Spain, and the differences between regions.
A cross-sectional study was conducted enrolling Spanish clinical laboratories. Primary care CD serology markers request in 2010, 2012 and 2014 from 15 autonomous communities (AACC), with more participants was reported. Test-utilization rates were calculated (tissue transglutaminase IgA antibodies (tTG-IgA) and deaminated peptide gliadine IgA antibodies (DGP-IgA) per 1000 inhabitants), and also the ratio of both tests request (DGP-IgA /tTG-IgA).
The request of tTG-IgA per 1000 inhabitants increased significantly along years (from 3.99 to 5.90 (P < 0.001)). The demand of DGP-IgA
1000 inhabitants was maintained in 2010 and 2012 (0.68 and 0.6), and decreased in 2014 (0.35) (P = 0.927). DGP-IgA /tTG-IgA diminished over time (from 0.16 to 0.06 (P = 0.548)), and in the 2014 edition, there was a significant regional difference, ranging from 0.01 to 0.57 (P < 0.001).
The variability in the request in CD serology markers emphasizes the need of inter-regional cooperation to develop strategies to optimize the use of laboratory tests.</description><identifier>ISSN: 1330-0962</identifier><identifier>ISSN: 1846-7482</identifier><identifier>EISSN: 1846-7482</identifier><identifier>DOI: 10.11613/BM.2017.025</identifier><identifier>PMID: 28392744</identifier><language>eng</language><publisher>Croatia: Medicinska naklada</publisher><subject>benchmarking ; Biomarkers - blood ; celiac disease ; Celiac Disease - blood ; Celiac Disease - diagnosis ; Clinical Chemistry Tests - standards ; clinical laboratory services ; Cross-Sectional Studies ; Humans ; Practice Patterns, Physicians' - standards ; Primary Health Care - standards ; Quality Control ; quality indicators ; Short Communication ; Spain</subject><ispartof>Biochemia Medica, 2017-02, Vol.27 (1), p.231-236</ispartof><rights>2017 Croatian Society of Medical Biochemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-5496fbf234029fea011b606771d4dfd7a181761d9a509960269031a4822ddef3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382849/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382849/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28392744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salinas, Maria</creatorcontrib><creatorcontrib>López-Garrigós, Maite</creatorcontrib><creatorcontrib>Flores, Emilio</creatorcontrib><creatorcontrib>Leiva-Salinas, Carlos</creatorcontrib><title>Big differences in primary care celiac disease serological markers request in Spain</title><title>Biochemia Medica</title><addtitle>Biochem Med (Zagreb)</addtitle><description>Celiac disease (CD) prevalence is increasing but the disorder remains undiagnosed. The study compares CD serology markers requested by General Practitioners (GPs) over time and geographical areas. The aim of the current research is to assess the inter-practice and temporal variability in the request of CD serology markers by GPs in Spain, and the differences between regions.
A cross-sectional study was conducted enrolling Spanish clinical laboratories. Primary care CD serology markers request in 2010, 2012 and 2014 from 15 autonomous communities (AACC), with more participants was reported. Test-utilization rates were calculated (tissue transglutaminase IgA antibodies (tTG-IgA) and deaminated peptide gliadine IgA antibodies (DGP-IgA) per 1000 inhabitants), and also the ratio of both tests request (DGP-IgA /tTG-IgA).
The request of tTG-IgA per 1000 inhabitants increased significantly along years (from 3.99 to 5.90 (P < 0.001)). The demand of DGP-IgA
1000 inhabitants was maintained in 2010 and 2012 (0.68 and 0.6), and decreased in 2014 (0.35) (P = 0.927). DGP-IgA /tTG-IgA diminished over time (from 0.16 to 0.06 (P = 0.548)), and in the 2014 edition, there was a significant regional difference, ranging from 0.01 to 0.57 (P < 0.001).
The variability in the request in CD serology markers emphasizes the need of inter-regional cooperation to develop strategies to optimize the use of laboratory tests.</description><subject>benchmarking</subject><subject>Biomarkers - blood</subject><subject>celiac disease</subject><subject>Celiac Disease - blood</subject><subject>Celiac Disease - diagnosis</subject><subject>Clinical Chemistry Tests - standards</subject><subject>clinical laboratory services</subject><subject>Cross-Sectional Studies</subject><subject>Humans</subject><subject>Practice Patterns, Physicians' - standards</subject><subject>Primary Health Care - standards</subject><subject>Quality Control</subject><subject>quality indicators</subject><subject>Short Communication</subject><subject>Spain</subject><issn>1330-0962</issn><issn>1846-7482</issn><issn>1846-7482</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtPAjEUhRujUXzsXJtZunCw72k3JkJ8JRAXum9K5xaqwwy2YOK_twoSWfWm_e7pPfcgdE5wnxBJ2PVg3KeYVH1MxR7qEcVlWXFF93PNGC6xlvQIHaf0hrEQQlWH6IgqpmnFeQ-9DMK0qIP3EKF1kIrQFosY5jZ-Fc5GKBw0wbqMJLAJigSxa7ppcLYpMvQOMRURPlaQlj-tLwsb2lN04G2T4GxznqDX-7vX4WM5en54Gt6OSscpXZaCa-knnjKOqfZgMSETiWVVkZrXvq4sUaSSpNZWYK0lplJjRmy2RusaPDtBN2vZxWoyh9pBu4y2MZvpTWeD2X1pw8xMu08jmKKK6yxQrgVm0dn3ncb1TYoOcmnyGILhzF9uPozdr2MzDynvp7EtdKtkiFKSCZ13m9GrNepil1IEv1Un2PzGZgZj8xObybFl_OK_lS38lxP7BvA7k3c</recordid><startdate>20170215</startdate><enddate>20170215</enddate><creator>Salinas, Maria</creator><creator>López-Garrigós, Maite</creator><creator>Flores, Emilio</creator><creator>Leiva-Salinas, Carlos</creator><general>Medicinska naklada</general><general>Croatian Society of Medical Biochemistry and Laboratory Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>VP8</scope><scope>5PM</scope></search><sort><creationdate>20170215</creationdate><title>Big differences in primary care celiac disease serological markers request in Spain</title><author>Salinas, Maria ; López-Garrigós, Maite ; Flores, Emilio ; Leiva-Salinas, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-5496fbf234029fea011b606771d4dfd7a181761d9a509960269031a4822ddef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>benchmarking</topic><topic>Biomarkers - blood</topic><topic>celiac disease</topic><topic>Celiac Disease - blood</topic><topic>Celiac Disease - diagnosis</topic><topic>Clinical Chemistry Tests - standards</topic><topic>clinical laboratory services</topic><topic>Cross-Sectional Studies</topic><topic>Humans</topic><topic>Practice Patterns, Physicians' - standards</topic><topic>Primary Health Care - standards</topic><topic>Quality Control</topic><topic>quality indicators</topic><topic>Short Communication</topic><topic>Spain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salinas, Maria</creatorcontrib><creatorcontrib>López-Garrigós, Maite</creatorcontrib><creatorcontrib>Flores, Emilio</creatorcontrib><creatorcontrib>Leiva-Salinas, Carlos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hrcak: Portal of scientific journals of Croatia</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemia Medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salinas, Maria</au><au>López-Garrigós, Maite</au><au>Flores, Emilio</au><au>Leiva-Salinas, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Big differences in primary care celiac disease serological markers request in Spain</atitle><jtitle>Biochemia Medica</jtitle><addtitle>Biochem Med (Zagreb)</addtitle><date>2017-02-15</date><risdate>2017</risdate><volume>27</volume><issue>1</issue><spage>231</spage><epage>236</epage><pages>231-236</pages><issn>1330-0962</issn><issn>1846-7482</issn><eissn>1846-7482</eissn><abstract>Celiac disease (CD) prevalence is increasing but the disorder remains undiagnosed. The study compares CD serology markers requested by General Practitioners (GPs) over time and geographical areas. The aim of the current research is to assess the inter-practice and temporal variability in the request of CD serology markers by GPs in Spain, and the differences between regions.
A cross-sectional study was conducted enrolling Spanish clinical laboratories. Primary care CD serology markers request in 2010, 2012 and 2014 from 15 autonomous communities (AACC), with more participants was reported. Test-utilization rates were calculated (tissue transglutaminase IgA antibodies (tTG-IgA) and deaminated peptide gliadine IgA antibodies (DGP-IgA) per 1000 inhabitants), and also the ratio of both tests request (DGP-IgA /tTG-IgA).
The request of tTG-IgA per 1000 inhabitants increased significantly along years (from 3.99 to 5.90 (P < 0.001)). The demand of DGP-IgA
1000 inhabitants was maintained in 2010 and 2012 (0.68 and 0.6), and decreased in 2014 (0.35) (P = 0.927). DGP-IgA /tTG-IgA diminished over time (from 0.16 to 0.06 (P = 0.548)), and in the 2014 edition, there was a significant regional difference, ranging from 0.01 to 0.57 (P < 0.001).
The variability in the request in CD serology markers emphasizes the need of inter-regional cooperation to develop strategies to optimize the use of laboratory tests.</abstract><cop>Croatia</cop><pub>Medicinska naklada</pub><pmid>28392744</pmid><doi>10.11613/BM.2017.025</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1330-0962 |
| ispartof | Biochemia Medica, 2017-02, Vol.27 (1), p.231-236 |
| issn | 1330-0962 1846-7482 1846-7482 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5382849 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | benchmarking Biomarkers - blood celiac disease Celiac Disease - blood Celiac Disease - diagnosis Clinical Chemistry Tests - standards clinical laboratory services Cross-Sectional Studies Humans Practice Patterns, Physicians' - standards Primary Health Care - standards Quality Control quality indicators Short Communication Spain |
| title | Big differences in primary care celiac disease serological markers request in Spain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T11%3A34%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Big%20differences%20in%20primary%20care%20celiac%20disease%20serological%20markers%20request%20in%20Spain&rft.jtitle=Biochemia%20Medica&rft.au=Salinas,%20Maria&rft.date=2017-02-15&rft.volume=27&rft.issue=1&rft.spage=231&rft.epage=236&rft.pages=231-236&rft.issn=1330-0962&rft.eissn=1846-7482&rft_id=info:doi/10.11613/BM.2017.025&rft_dat=%3Cproquest_pubme%3E1886359839%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1886359839&rft_id=info:pmid/28392744&rfr_iscdi=true |