Association between the CD24 Ala57Val polymorphism and risk for multiple sclerosis and systemic lupus erythematosus: a meta-analysis
The cluster of differentiation 24 ( CD24 ) Ala57Val polymorphism has been implicated as a risk factor for multiple sclerosis (MS) and systemic lupus erythematosus (SLE); however, genetic studies have produced controversial results. A meta-analysis was performed on this topic. We used odds ratio (OR)...
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| description | The cluster of differentiation 24 (
CD24
) Ala57Val polymorphism has been implicated as a risk factor for multiple sclerosis (MS) and systemic lupus erythematosus (SLE); however, genetic studies have produced controversial results. A meta-analysis was performed on this topic. We used odds ratio (OR) and 95% confidence interval (95% CI) to investigate the strength of association. Eleven studies from nine publications consisting of 2466 cases and 2650 controls were included. The results suggested that the
CD24
Val/Val genotypes were associated with an increased risk of MS in all study subjects and Caucasians (OR = 2.28, 95% CI: 1.68–3.10,
P
z
< 0.001 and OR = 2.30, 95% CI: 1.66–3.20,
P
z
< 0.001, respectively). Sensitivity analysis showed that no individual study was found to be significantly biasing the pooled results. Although meta-analysis also suggested an association between the
CD24
Val/Val genotypes and SLE risk in Caucasians (OR = 1.71, 95% CI: 1.31–2.24,
P
z
< 0.001), sensitivity analysis demonstrated that the association was not statistically significant after removing a Spanish study. In conclusion, this meta-analysis suggests that the
CD24
Ala57Val polymorphism is associated with an increased risk of MS in Caucasians. However, the available evidence is not sufficient to support an association between the
CD24
Ala57Val polymorphism and SLE risk. |
| doi_str_mv | 10.1038/srep09557 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5381688</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1669835100</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-7b4f5622c3deac6e6cfc89df1420421a3f9e7b84c7b382cf72f695ee4379695c3</originalsourceid><addsrcrecordid>eNplkU9v1DAQxSMEolXbA18AWeIClQKxHTs2h0qrLf-kSlyAa-R4J10XJw4eB5Q7H7wuW1YL9cUjvZ_fzPgVxTNavaYVV28wwlRpIZpHxTGralEyztjjg_qoOEO8qfIRTNdUPy2OmFC80pweF79XiME6k1wYSQfpF8BI0hbI-pLVZOWNaL4ZT6bglyHEaetwIGbckOjwO-lDJMPsk5s8ELQeYkCHf3RcMMHgLPHzNCOBuGTTwaSAM74lhgyQTGlG45f84rR40huPcHZ_nxRf37_7sv5YXn3-8Gm9uiptzVUqm67uhWTM8g0YK0Ha3iq96Wmdd2XU8F5D06naNh1XzPYN66UWADVvdC4sPykudr7T3A2wsTCmaHw7RTeYuLTBuPZfZXTb9jr8bAVXVCqVDV7eG8TwYwZM7eDQgvdmhDBjS6XUigtaVRl98R96E-aYF86U0kpy3kiWqVc7yuavy0n2-2Fo1d7F2-7jzezzw-n35N8wM3C-AzBL4zXEg5YP3G4Bm9Oxew</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1898633762</pqid></control><display><type>article</type><title>Association between the CD24 Ala57Val polymorphism and risk for multiple sclerosis and systemic lupus erythematosus: a meta-analysis</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature OA Free Journals</source><creator>Huang, Jian ; Yang, Yaqi ; Liang, Zibin ; Kang, Miaomiao ; Kuang, Ying ; Li, Feng</creator><creatorcontrib>Huang, Jian ; Yang, Yaqi ; Liang, Zibin ; Kang, Miaomiao ; Kuang, Ying ; Li, Feng</creatorcontrib><description>The cluster of differentiation 24 (
CD24
) Ala57Val polymorphism has been implicated as a risk factor for multiple sclerosis (MS) and systemic lupus erythematosus (SLE); however, genetic studies have produced controversial results. A meta-analysis was performed on this topic. We used odds ratio (OR) and 95% confidence interval (95% CI) to investigate the strength of association. Eleven studies from nine publications consisting of 2466 cases and 2650 controls were included. The results suggested that the
CD24
Val/Val genotypes were associated with an increased risk of MS in all study subjects and Caucasians (OR = 2.28, 95% CI: 1.68–3.10,
P
z
< 0.001 and OR = 2.30, 95% CI: 1.66–3.20,
P
z
< 0.001, respectively). Sensitivity analysis showed that no individual study was found to be significantly biasing the pooled results. Although meta-analysis also suggested an association between the
CD24
Val/Val genotypes and SLE risk in Caucasians (OR = 1.71, 95% CI: 1.31–2.24,
P
z
< 0.001), sensitivity analysis demonstrated that the association was not statistically significant after removing a Spanish study. In conclusion, this meta-analysis suggests that the
CD24
Ala57Val polymorphism is associated with an increased risk of MS in Caucasians. However, the available evidence is not sufficient to support an association between the
CD24
Ala57Val polymorphism and SLE risk.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep09557</identifier><identifier>PMID: 25830931</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/77 ; 45/88 ; 692/308/2056 ; 692/499 ; 692/699/249/1313/1666 ; Alleles ; Amino Acid Substitution ; Autoimmune diseases ; CD24 Antigen - genetics ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotypes ; Humanities and Social Sciences ; Humans ; Immunology ; Lupus ; Lupus Erythematosus, Systemic - genetics ; Meta-analysis ; multidisciplinary ; Multiple sclerosis ; Multiple Sclerosis - genetics ; Odds Ratio ; Polymorphism, Single Nucleotide ; Publication Bias ; Risk ; Risk factors ; Science ; Sensitivity analysis ; Systemic lupus erythematosus ; White people</subject><ispartof>Scientific reports, 2015-04, Vol.5 (1), p.9557-9557, Article 9557</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Apr 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited. All rights reserved 2015 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-7b4f5622c3deac6e6cfc89df1420421a3f9e7b84c7b382cf72f695ee4379695c3</citedby><cites>FETCH-LOGICAL-c438t-7b4f5622c3deac6e6cfc89df1420421a3f9e7b84c7b382cf72f695ee4379695c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381688/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381688/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25830931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Jian</creatorcontrib><creatorcontrib>Yang, Yaqi</creatorcontrib><creatorcontrib>Liang, Zibin</creatorcontrib><creatorcontrib>Kang, Miaomiao</creatorcontrib><creatorcontrib>Kuang, Ying</creatorcontrib><creatorcontrib>Li, Feng</creatorcontrib><title>Association between the CD24 Ala57Val polymorphism and risk for multiple sclerosis and systemic lupus erythematosus: a meta-analysis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The cluster of differentiation 24 (
CD24
) Ala57Val polymorphism has been implicated as a risk factor for multiple sclerosis (MS) and systemic lupus erythematosus (SLE); however, genetic studies have produced controversial results. A meta-analysis was performed on this topic. We used odds ratio (OR) and 95% confidence interval (95% CI) to investigate the strength of association. Eleven studies from nine publications consisting of 2466 cases and 2650 controls were included. The results suggested that the
CD24
Val/Val genotypes were associated with an increased risk of MS in all study subjects and Caucasians (OR = 2.28, 95% CI: 1.68–3.10,
P
z
< 0.001 and OR = 2.30, 95% CI: 1.66–3.20,
P
z
< 0.001, respectively). Sensitivity analysis showed that no individual study was found to be significantly biasing the pooled results. Although meta-analysis also suggested an association between the
CD24
Val/Val genotypes and SLE risk in Caucasians (OR = 1.71, 95% CI: 1.31–2.24,
P
z
< 0.001), sensitivity analysis demonstrated that the association was not statistically significant after removing a Spanish study. In conclusion, this meta-analysis suggests that the
CD24
Ala57Val polymorphism is associated with an increased risk of MS in Caucasians. However, the available evidence is not sufficient to support an association between the
CD24
Ala57Val polymorphism and SLE risk.</description><subject>45/77</subject><subject>45/88</subject><subject>692/308/2056</subject><subject>692/499</subject><subject>692/699/249/1313/1666</subject><subject>Alleles</subject><subject>Amino Acid Substitution</subject><subject>Autoimmune diseases</subject><subject>CD24 Antigen - genetics</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotypes</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunology</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Meta-analysis</subject><subject>multidisciplinary</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - genetics</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Publication Bias</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Science</subject><subject>Sensitivity analysis</subject><subject>Systemic lupus erythematosus</subject><subject>White people</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkU9v1DAQxSMEolXbA18AWeIClQKxHTs2h0qrLf-kSlyAa-R4J10XJw4eB5Q7H7wuW1YL9cUjvZ_fzPgVxTNavaYVV28wwlRpIZpHxTGralEyztjjg_qoOEO8qfIRTNdUPy2OmFC80pweF79XiME6k1wYSQfpF8BI0hbI-pLVZOWNaL4ZT6bglyHEaetwIGbckOjwO-lDJMPsk5s8ELQeYkCHf3RcMMHgLPHzNCOBuGTTwaSAM74lhgyQTGlG45f84rR40huPcHZ_nxRf37_7sv5YXn3-8Gm9uiptzVUqm67uhWTM8g0YK0Ha3iq96Wmdd2XU8F5D06naNh1XzPYN66UWADVvdC4sPykudr7T3A2wsTCmaHw7RTeYuLTBuPZfZXTb9jr8bAVXVCqVDV7eG8TwYwZM7eDQgvdmhDBjS6XUigtaVRl98R96E-aYF86U0kpy3kiWqVc7yuavy0n2-2Fo1d7F2-7jzezzw-n35N8wM3C-AzBL4zXEg5YP3G4Bm9Oxew</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Huang, Jian</creator><creator>Yang, Yaqi</creator><creator>Liang, Zibin</creator><creator>Kang, Miaomiao</creator><creator>Kuang, Ying</creator><creator>Li, Feng</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150401</creationdate><title>Association between the CD24 Ala57Val polymorphism and risk for multiple sclerosis and systemic lupus erythematosus: a meta-analysis</title><author>Huang, Jian ; Yang, Yaqi ; Liang, Zibin ; Kang, Miaomiao ; Kuang, Ying ; Li, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-7b4f5622c3deac6e6cfc89df1420421a3f9e7b84c7b382cf72f695ee4379695c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>45/77</topic><topic>45/88</topic><topic>692/308/2056</topic><topic>692/499</topic><topic>692/699/249/1313/1666</topic><topic>Alleles</topic><topic>Amino Acid Substitution</topic><topic>Autoimmune diseases</topic><topic>CD24 Antigen - genetics</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotypes</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunology</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - genetics</topic><topic>Meta-analysis</topic><topic>multidisciplinary</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - genetics</topic><topic>Odds Ratio</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Publication Bias</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Science</topic><topic>Sensitivity analysis</topic><topic>Systemic lupus erythematosus</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Jian</creatorcontrib><creatorcontrib>Yang, Yaqi</creatorcontrib><creatorcontrib>Liang, Zibin</creatorcontrib><creatorcontrib>Kang, Miaomiao</creatorcontrib><creatorcontrib>Kuang, Ying</creatorcontrib><creatorcontrib>Li, Feng</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Jian</au><au>Yang, Yaqi</au><au>Liang, Zibin</au><au>Kang, Miaomiao</au><au>Kuang, Ying</au><au>Li, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between the CD24 Ala57Val polymorphism and risk for multiple sclerosis and systemic lupus erythematosus: a meta-analysis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>9557</spage><epage>9557</epage><pages>9557-9557</pages><artnum>9557</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The cluster of differentiation 24 (
CD24
) Ala57Val polymorphism has been implicated as a risk factor for multiple sclerosis (MS) and systemic lupus erythematosus (SLE); however, genetic studies have produced controversial results. A meta-analysis was performed on this topic. We used odds ratio (OR) and 95% confidence interval (95% CI) to investigate the strength of association. Eleven studies from nine publications consisting of 2466 cases and 2650 controls were included. The results suggested that the
CD24
Val/Val genotypes were associated with an increased risk of MS in all study subjects and Caucasians (OR = 2.28, 95% CI: 1.68–3.10,
P
z
< 0.001 and OR = 2.30, 95% CI: 1.66–3.20,
P
z
< 0.001, respectively). Sensitivity analysis showed that no individual study was found to be significantly biasing the pooled results. Although meta-analysis also suggested an association between the
CD24
Val/Val genotypes and SLE risk in Caucasians (OR = 1.71, 95% CI: 1.31–2.24,
P
z
< 0.001), sensitivity analysis demonstrated that the association was not statistically significant after removing a Spanish study. In conclusion, this meta-analysis suggests that the
CD24
Ala57Val polymorphism is associated with an increased risk of MS in Caucasians. However, the available evidence is not sufficient to support an association between the
CD24
Ala57Val polymorphism and SLE risk.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25830931</pmid><doi>10.1038/srep09557</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 45/77 45/88 692/308/2056 692/499 692/699/249/1313/1666 Alleles Amino Acid Substitution Autoimmune diseases CD24 Antigen - genetics Genetic Association Studies Genetic Predisposition to Disease Genotypes Humanities and Social Sciences Humans Immunology Lupus Lupus Erythematosus, Systemic - genetics Meta-analysis multidisciplinary Multiple sclerosis Multiple Sclerosis - genetics Odds Ratio Polymorphism, Single Nucleotide Publication Bias Risk Risk factors Science Sensitivity analysis Systemic lupus erythematosus White people |
| title | Association between the CD24 Ala57Val polymorphism and risk for multiple sclerosis and systemic lupus erythematosus: a meta-analysis |
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