Inhibition of STAT3 with the Generation 2.5 Antisense Oligonucleotide, AZD9150, Decreases Neuroblastoma Tumorigenicity and Increases Chemosensitivity

Neuroblastoma is a pediatric tumor of peripheral sympathoadrenal neuroblasts. The long-term event-free survival of children with high-risk neuroblastoma is still poor despite the improvements with current multimodality treatment protocols. Activated JAK/STAT3 pathway plays an important role in many...

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Veröffentlicht in:	Clinical cancer research 2017-04, Vol.23 (7), p.1771-1784
Hauptverfasser:	Odate, Seiichi, Veschi, Veronica, Yan, Shuang, Lam, Norris, Woessner, Richard, Thiele, Carol J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Animal models Animals Antineoplastic Combined Chemotherapy Protocols Antisense oligonucleotides Apoptosis - drug effects Cancer Carcinogenesis - drug effects Cell culture Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Children Cisplatin Cisplatin - administration & dosage Experimental design Gene Expression Regulation, Neoplastic - drug effects Health risks Humans In vivo methods and tests Inhibition Mice Neuroblastoma Neuroblastoma - drug therapy Neuroblastoma - genetics Neuroblastoma - pathology Neuroblasts Oligonucleotides - administration & dosage Oligonucleotides, Antisense - administration & dosage Risk Stat3 protein STAT3 Transcription Factor - genetics Survival Sympathetic nervous system Tumor cells Tumorigenicity Tumors Xenograft Model Antitumor Assays Xenografts
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