Screening of Newborns for Disorders with High Benefit-Risk Ratios Should Be Mandatory
Newborn screening has evolved to include an increasingly complex spectrum of diseases, raising concerns that screening should be optional and require parental consent. Early detection of disorders like PKU and MCAD is essential to prevent serious disability and death in affected children. These are...
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| Veröffentlicht in: | The Journal of law, medicine & ethics medicine & ethics, 2016-06, Vol.44 (2), p.231-240 |
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| creator | Kelly, Nicole Makarem, Dalia Chehayeb Wasserstein, Melissa P. |
| description | Newborn screening has evolved to include an increasingly complex spectrum of diseases, raising concerns that screening should be optional and require parental consent. Early detection of disorders like PKU and MCAD is essential to prevent serious disability and death in affected children. These are examples of high benefit-risk ratio disorders because of the irrefutable health benefits of early detection, coupled with the low risks of treatment. The dire consequences of not diagnosing an infant with a treatable disorder because of parental refusal to screen are wholly unacceptable. Thus, we believe that newborn screening for disorders with high benefit-risk ratios should continue to be mandatory. |
| doi_str_mv | 10.1177/1073110516654133 |
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Early detection of disorders like PKU and MCAD is essential to prevent serious disability and death in affected children. These are examples of high benefit-risk ratio disorders because of the irrefutable health benefits of early detection, coupled with the low risks of treatment. The dire consequences of not diagnosing an infant with a treatable disorder because of parental refusal to screen are wholly unacceptable. Thus, we believe that newborn screening for disorders with high benefit-risk ratios should continue to be mandatory.</description><identifier>ISSN: 1073-1105</identifier><identifier>EISSN: 1748-720X</identifier><identifier>DOI: 10.1177/1073110516654133</identifier><identifier>PMID: 27338599</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Babies ; Congenital diseases ; Decision making ; Dehydrogenases ; Disease ; Disorders ; Government regulation ; Health risk assessment ; Health technology assessment ; Humans ; Hypothyroidism ; Infant, Newborn ; Infants ; Infants (Newborn) ; Informed consent ; Laws, regulations and rules ; Medical diagnosis ; Medical examination ; Medical screening ; Mortality ; Neonatal Screening ; Newborn babies ; Odds Ratio ; Parental Consent ; Parents & parenting ; Phenylketonuria ; Retention ; Risk ; Risk Assessment</subject><ispartof>The Journal of law, medicine & ethics, 2016-06, Vol.44 (2), p.231-240</ispartof><rights>2016 American Society of Law, Medicine & Ethics</rights><rights>2016 American Society of Law, Medicine & Ethics.</rights><rights>COPYRIGHT 2016 Sage Publications, Inc.</rights><rights>COPYRIGHT 2016 Sage Publications, Inc.</rights><rights>Copyright © American Society of Law, Medicine and Ethics 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c670t-52313dc697274cb68b1a3d2e2a2ecb1ff1f6f87c94265f12df64bec35ee17c6e3</citedby><cites>FETCH-LOGICAL-c670t-52313dc697274cb68b1a3d2e2a2ecb1ff1f6f87c94265f12df64bec35ee17c6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27843,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27338599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelly, Nicole</creatorcontrib><creatorcontrib>Makarem, Dalia Chehayeb</creatorcontrib><creatorcontrib>Wasserstein, Melissa P.</creatorcontrib><title>Screening of Newborns for Disorders with High Benefit-Risk Ratios Should Be Mandatory</title><title>The Journal of law, medicine & ethics</title><addtitle>J Law Med Ethics</addtitle><description>Newborn screening has evolved to include an increasingly complex spectrum of diseases, raising concerns that screening should be optional and require parental consent. Early detection of disorders like PKU and MCAD is essential to prevent serious disability and death in affected children. These are examples of high benefit-risk ratio disorders because of the irrefutable health benefits of early detection, coupled with the low risks of treatment. The dire consequences of not diagnosing an infant with a treatable disorder because of parental refusal to screen are wholly unacceptable. Thus, we believe that newborn screening for disorders with high benefit-risk ratios should continue to be mandatory.</description><subject>Babies</subject><subject>Congenital diseases</subject><subject>Decision making</subject><subject>Dehydrogenases</subject><subject>Disease</subject><subject>Disorders</subject><subject>Government regulation</subject><subject>Health risk assessment</subject><subject>Health technology assessment</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infants (Newborn)</subject><subject>Informed consent</subject><subject>Laws, regulations and rules</subject><subject>Medical diagnosis</subject><subject>Medical examination</subject><subject>Medical screening</subject><subject>Mortality</subject><subject>Neonatal Screening</subject><subject>Newborn babies</subject><subject>Odds Ratio</subject><subject>Parental Consent</subject><subject>Parents & parenting</subject><subject>Phenylketonuria</subject><subject>Retention</subject><subject>Risk</subject><subject>Risk 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screening</topic><topic>Mortality</topic><topic>Neonatal Screening</topic><topic>Newborn babies</topic><topic>Odds Ratio</topic><topic>Parental Consent</topic><topic>Parents & parenting</topic><topic>Phenylketonuria</topic><topic>Retention</topic><topic>Risk</topic><topic>Risk Assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelly, Nicole</creatorcontrib><creatorcontrib>Makarem, Dalia Chehayeb</creatorcontrib><creatorcontrib>Wasserstein, Melissa P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale OneFile: LegalTrac</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest 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Early detection of disorders like PKU and MCAD is essential to prevent serious disability and death in affected children. These are examples of high benefit-risk ratio disorders because of the irrefutable health benefits of early detection, coupled with the low risks of treatment. The dire consequences of not diagnosing an infant with a treatable disorder because of parental refusal to screen are wholly unacceptable. Thus, we believe that newborn screening for disorders with high benefit-risk ratios should continue to be mandatory.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>27338599</pmid><doi>10.1177/1073110516654133</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1073-1105 |
| ispartof | The Journal of law, medicine & ethics, 2016-06, Vol.44 (2), p.231-240 |
| issn | 1073-1105 1748-720X |
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| source | MEDLINE; PAIS Index; HeinOnline Law Journal Library |
| subjects | Babies Congenital diseases Decision making Dehydrogenases Disease Disorders Government regulation Health risk assessment Health technology assessment Humans Hypothyroidism Infant, Newborn Infants Infants (Newborn) Informed consent Laws, regulations and rules Medical diagnosis Medical examination Medical screening Mortality Neonatal Screening Newborn babies Odds Ratio Parental Consent Parents & parenting Phenylketonuria Retention Risk Risk Assessment |
| title | Screening of Newborns for Disorders with High Benefit-Risk Ratios Should Be Mandatory |
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