NK cell education via nonclassical MHC and non-MHC ligands
Natural killer （NK） cell education, a process for achieving functional maturation and self-tolerance, has been previously defined by the interaction between self-major histocompatibility complex class I （MHC-I） molecules and their specific inhibitory receptors. Over the past several years, growing e...
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| Veröffentlicht in: | Cellular & molecular immunology 2017-04, Vol.14 (4), p.321-330 |
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| creator | He, Yuke Tian, Zhigang |
| description | Natural killer （NK） cell education, a process for achieving functional maturation and self-tolerance, has been previously defined by the interaction between self-major histocompatibility complex class I （MHC-I） molecules and their specific inhibitory receptors. Over the past several years, growing evidence has highlighted the important roles of nonclassical MHC-I and non-MHC-I molecules in NK cell education. Herein, we review the current knowledge of NK cell education, with a particular focus on nonclassical MHC-I- and non-MHC-I-dependent education, and compare them with the classical MHC-I-dependent education theory. In addition, we update and extend this theory by presenting the ＇Confining Model＇, discussing cis and trans characteristics, reassessing quantity and quality control, and elucidating the redundancy of NK cell education in tumor and virus infection. |
| doi_str_mv | 10.1038/cmi.2016.26 |
| format | Article |
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Over the past several years, growing evidence has highlighted the important roles of nonclassical MHC-I and non-MHC-I molecules in NK cell education. Herein, we review the current knowledge of NK cell education, with a particular focus on nonclassical MHC-I- and non-MHC-I-dependent education, and compare them with the classical MHC-I-dependent education theory. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antibodies Biomedical and Life Sciences Biomedicine Histocompatibility Antigens - immunology Humans Immunology Killer Cells, Natural - immunology Ligands Medical Microbiology MHC Microbiology Neoplasms - immunology NK细胞 Review Signal Transduction - immunology Vaccine Virus Diseases - immunology 控制方案 教育理论 病毒感染 相互作用 配体 非经典 |
| title | NK cell education via nonclassical MHC and non-MHC ligands |
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