Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity

Poor prognosis of ovarian cancer, the deadliest of the gynecologic malignancies, reflects major limitations associated with detection and diagnosis. Current methods lack high sensitivity to detect small tumors and high specificity to distinguish malignant from benign tissue, both impeding diagnosis...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2017-04, Vol.77 (7), p.1684-1696
Hauptverfasser:	Sundaram, Karthik M, Zhang, Yilin, Mitra, Anirban K, Kouadio, Jean-Louis K, Gwin, Katja, Kossiakoff, Anthony A, Roman, Brian B, Lengyel, Ernst, Piccirilli, Joseph A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Carcinoma, Ovarian Epithelial Cell culture Cell Line, Tumor Diagnosis Endocytosis Female Fluorescence Gadolinium Gadolinium DTPA Humans I.R. radiation Infrared imaging Internalization Invasiveness Magnetic resonance imaging Magnetic Resonance Imaging - methods Metastases Mice Neoplasms, Glandular and Epithelial - diagnostic imaging Neoplasms, Glandular and Epithelial - metabolism NMR Nuclear magnetic resonance Ovarian cancer Ovarian Neoplasms - diagnostic imaging Ovarian Neoplasms - metabolism Placenta Placental Lactogen - metabolism Prolactin Prolactin - metabolism Receptors, Prolactin - analysis Receptors, Prolactin - physiology Rodents Sensitivity Sensitivity and Specificity Tissue analysis Tissue Array Analysis Tissue culture Tumors
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