Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients with Idiopathic Dilated Cardiomyopathy

Abstract Background While fibrosis seems to be prognostic for adverse outcomes in adults with idiopathic dilated cardiomyopathy (IDC), little is known about the prevalence and development of fibrosis in pediatric IDC hearts. We hypothesize there is less activation of fibrosis at a molecular level in...

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Veröffentlicht in:	Journal of cardiac failure 2017-04, Vol.23 (4), p.314-324
Hauptverfasser:	Woulfe, Kathleen C., PhD, Siomos, Austine K., MD, Nguyen, Hieu, SooHoo, Megan, MD, Galambo, Csaba, MD, Stauffer, Brian L., MD, Sucharov, Carmen, PhD, Miyamoto, Shelley, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Cardiomyopathy, Dilated - complications Cardiovascular Child Female Fibrosis Galectin 3 - analysis gene expression Gene Expression Profiling Heart Failure - etiology Heart Failure - metabolism Heart Failure - pathology Heart Ventricles - metabolism Heart Ventricles - pathology Humans Interleukin-1 - analysis Male Matrix Metalloproteinase 2 - analysis MicroRNAs - genetics Middle Aged Myocardium - metabolism Myocardium - pathology Pediatric idiopathic cardiomyopathy Signal Transduction Statistics as Topic Tissue Inhibitor of Metalloproteinases - analysis
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