Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging
Amide proton transfer (APT) imaging is a noninvasive molecular magnetic resonance imaging (MRI) technique based on the chemical exchange-dependent saturation transfer mechanism. The purpose of this study was to investigate the diagnostic performance of APT MRI in detecting intracranial hemorrhage (I...
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| Veröffentlicht in: | Scientific reports 2017-04, Vol.7 (1), p.45696-45696, Article 45696 |
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| description | Amide proton transfer (APT) imaging is a noninvasive molecular magnetic resonance imaging (MRI) technique based on the chemical exchange-dependent saturation transfer mechanism. The purpose of this study was to investigate the diagnostic performance of APT MRI in detecting intracranial hemorrhage (ICH) at hyperacute, acute and subacute stages by comparing with susceptibility weighted imaging (SWI). APT MRI and SWI were performed on 33 included patients with ICH by using a 3-T MRI unit. A two-sided Mann-Whitney
U
test was used to detect differences in APT-weighted (APTw) and SWI signal intensities of ICH at hyperacute, acute and subacute stages. Receiver operating characteristic analysis was used to assess the diagnostic utilities of APT MRI and SWI. Our results showed that APT MRI could detect ICH at hyperacute, acute and subacute stages. Therefore, APTw signal intensity may serve as a reliable, noninvasive imaging biomarker for detecting ICH at hyperacute, acute and subacute stages. Moreover, APT MRI could provide additional information for the ICH compared with SWI. |
| doi_str_mv | 10.1038/srep45696 |
| format | Article |
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U
test was used to detect differences in APT-weighted (APTw) and SWI signal intensities of ICH at hyperacute, acute and subacute stages. Receiver operating characteristic analysis was used to assess the diagnostic utilities of APT MRI and SWI. Our results showed that APT MRI could detect ICH at hyperacute, acute and subacute stages. Therefore, APTw signal intensity may serve as a reliable, noninvasive imaging biomarker for detecting ICH at hyperacute, acute and subacute stages. Moreover, APT MRI could provide additional information for the ICH compared with SWI.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep45696</identifier><identifier>PMID: 28374764</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53/2421 ; 692/699/375/1370/534 ; Adult ; Aged ; Aged, 80 and over ; Amides - chemistry ; Biomarkers - metabolism ; Brain - metabolism ; Brain - pathology ; Comparative studies ; Female ; Hemorrhage ; Humanities and Social Sciences ; Humans ; Intracranial Hemorrhages - diagnosis ; Intracranial Hemorrhages - metabolism ; Intracranial Hemorrhages - pathology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; multidisciplinary ; NMR ; Nuclear magnetic resonance ; Protons ; Science ; Young Adult</subject><ispartof>Scientific reports, 2017-04, Vol.7 (1), p.45696-45696, Article 45696</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Apr 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f79328ad812fd30c1ac7e2910c7f7851ed0842fb533ffda8b7fe9fe72576de2b3</citedby><cites>FETCH-LOGICAL-c438t-f79328ad812fd30c1ac7e2910c7f7851ed0842fb533ffda8b7fe9fe72576de2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379544/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379544/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28374764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Xiaoyue</creatorcontrib><creatorcontrib>Bai, Yan</creatorcontrib><creatorcontrib>Lin, Yusong</creatorcontrib><creatorcontrib>Hong, Xiaohua</creatorcontrib><creatorcontrib>Liu, Taiyuan</creatorcontrib><creatorcontrib>Ma, Lun</creatorcontrib><creatorcontrib>Haacke, E Mark</creatorcontrib><creatorcontrib>Zhou, Jinyuan</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Wang, Meiyun</creatorcontrib><title>Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Amide proton transfer (APT) imaging is a noninvasive molecular magnetic resonance imaging (MRI) technique based on the chemical exchange-dependent saturation transfer mechanism. The purpose of this study was to investigate the diagnostic performance of APT MRI in detecting intracranial hemorrhage (ICH) at hyperacute, acute and subacute stages by comparing with susceptibility weighted imaging (SWI). APT MRI and SWI were performed on 33 included patients with ICH by using a 3-T MRI unit. A two-sided Mann-Whitney
U
test was used to detect differences in APT-weighted (APTw) and SWI signal intensities of ICH at hyperacute, acute and subacute stages. Receiver operating characteristic analysis was used to assess the diagnostic utilities of APT MRI and SWI. Our results showed that APT MRI could detect ICH at hyperacute, acute and subacute stages. Therefore, APTw signal intensity may serve as a reliable, noninvasive imaging biomarker for detecting ICH at hyperacute, acute and subacute stages. Moreover, APT MRI could provide additional information for the ICH compared with SWI.</description><subject>692/53/2421</subject><subject>692/699/375/1370/534</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amides - chemistry</subject><subject>Biomarkers - metabolism</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Comparative studies</subject><subject>Female</subject><subject>Hemorrhage</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Intracranial Hemorrhages - diagnosis</subject><subject>Intracranial Hemorrhages - metabolism</subject><subject>Intracranial Hemorrhages - pathology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Protons</subject><subject>Science</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplUU1rFTEUHUSxpXbhH5CAGxVeO_mYScaFUErVQqEbXYdMcjOTMpOMSabS3-MfbR6vfTw1myTnnnvuuZyqeovrM1xTcZ4iLKxpu_ZFdUxq1mwIJeTlwfuoOk3pri6nIR3D3evqiAjKGW_ZcfXnYnYG0BJDDh7lqHyyENGsBg_ZaRQhBa-8BuQK5vyAnEcGMui8-5QWXbqcmtAIc4hxVAMglZFxtiiBzyjlAqXPSCEd5kVFld09FHQ1D-i3yyNKa9KwZNe7yeWCgRvGDOZ55JvqlVVTgtOn-6T6-fXqx-X3zc3tt-vLi5uNZlTkjeUdJUIZgYk1tNZYaQ6kw7XmlosGg6kFI7ZvKLXWKNFzC50FThreGiA9Pam-7HSXtZ_BaNguN8klFh_xQQbl5N8V70Y5hHvZUN41jBWBD08CMfxaIWU5u7LZNCkPYU0SC8Fw2xYXhfr-H-pdWKMv60nc1ZQ1jPCt4McdS8eQStB2bwbXcpu-3KdfuO8O3e-Zz1kXwqcdIZWSHyAejPxP7REwR78X</recordid><startdate>20170404</startdate><enddate>20170404</enddate><creator>Ma, Xiaoyue</creator><creator>Bai, Yan</creator><creator>Lin, Yusong</creator><creator>Hong, Xiaohua</creator><creator>Liu, Taiyuan</creator><creator>Ma, Lun</creator><creator>Haacke, E Mark</creator><creator>Zhou, Jinyuan</creator><creator>Wang, Jian</creator><creator>Wang, Meiyun</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170404</creationdate><title>Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging</title><author>Ma, Xiaoyue ; Bai, Yan ; Lin, Yusong ; Hong, Xiaohua ; Liu, Taiyuan ; Ma, Lun ; Haacke, E Mark ; Zhou, Jinyuan ; Wang, Jian ; Wang, Meiyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-f79328ad812fd30c1ac7e2910c7f7851ed0842fb533ffda8b7fe9fe72576de2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>692/53/2421</topic><topic>692/699/375/1370/534</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amides - chemistry</topic><topic>Biomarkers - metabolism</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Comparative studies</topic><topic>Female</topic><topic>Hemorrhage</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Intracranial Hemorrhages - diagnosis</topic><topic>Intracranial Hemorrhages - metabolism</topic><topic>Intracranial Hemorrhages - pathology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Protons</topic><topic>Science</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Xiaoyue</creatorcontrib><creatorcontrib>Bai, Yan</creatorcontrib><creatorcontrib>Lin, Yusong</creatorcontrib><creatorcontrib>Hong, Xiaohua</creatorcontrib><creatorcontrib>Liu, Taiyuan</creatorcontrib><creatorcontrib>Ma, Lun</creatorcontrib><creatorcontrib>Haacke, E Mark</creatorcontrib><creatorcontrib>Zhou, Jinyuan</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Wang, Meiyun</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Xiaoyue</au><au>Bai, Yan</au><au>Lin, Yusong</au><au>Hong, Xiaohua</au><au>Liu, Taiyuan</au><au>Ma, Lun</au><au>Haacke, E Mark</au><au>Zhou, Jinyuan</au><au>Wang, Jian</au><au>Wang, Meiyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-04-04</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>45696</spage><epage>45696</epage><pages>45696-45696</pages><artnum>45696</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Amide proton transfer (APT) imaging is a noninvasive molecular magnetic resonance imaging (MRI) technique based on the chemical exchange-dependent saturation transfer mechanism. The purpose of this study was to investigate the diagnostic performance of APT MRI in detecting intracranial hemorrhage (ICH) at hyperacute, acute and subacute stages by comparing with susceptibility weighted imaging (SWI). APT MRI and SWI were performed on 33 included patients with ICH by using a 3-T MRI unit. A two-sided Mann-Whitney
U
test was used to detect differences in APT-weighted (APTw) and SWI signal intensities of ICH at hyperacute, acute and subacute stages. Receiver operating characteristic analysis was used to assess the diagnostic utilities of APT MRI and SWI. Our results showed that APT MRI could detect ICH at hyperacute, acute and subacute stages. Therefore, APTw signal intensity may serve as a reliable, noninvasive imaging biomarker for detecting ICH at hyperacute, acute and subacute stages. Moreover, APT MRI could provide additional information for the ICH compared with SWI.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28374764</pmid><doi>10.1038/srep45696</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/53/2421 692/699/375/1370/534 Adult Aged Aged, 80 and over Amides - chemistry Biomarkers - metabolism Brain - metabolism Brain - pathology Comparative studies Female Hemorrhage Humanities and Social Sciences Humans Intracranial Hemorrhages - diagnosis Intracranial Hemorrhages - metabolism Intracranial Hemorrhages - pathology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged multidisciplinary NMR Nuclear magnetic resonance Protons Science Young Adult |
| title | Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging |
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