Parkinson's Disease, Lights and Melanocytes: Looking Beyond the Retina
Critical analysis of recent research suggesting that light pollution causes Parkinson's disease (PD) reveals that such a hypothesis is unsustainable in the context of therapeutic use of light in treating various neuropsychiatric conditions. Reinterpretation of their findings suggests that retin...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2014-01, Vol.4 (1), p.3921, Article 3921 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 3921 |
| container_title | Scientific reports |
| container_volume | 4 |
| creator | Willis, Gregory L. Moore, Cleo Armstrong, Stuart Maxwell |
| description | Critical analysis of recent research suggesting that light pollution causes Parkinson's disease (PD) reveals that such a hypothesis is unsustainable in the context of therapeutic use of light in treating various neuropsychiatric conditions. Reinterpretation of their findings suggests that retinal damage caused by prolonged light exposure may have contributed to the observed enhancement of experimental PD. To test this hypothesis further, forty-two Sprague Dawley rats received microinjections of 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-2, 4, 6-tetrahydropyridine (MPTP), paraquat or rotenone into the vitreal mass in doses so minute that the effects could not be attributed to diffusion into brain. Significant changes in five motor parameters consistent with symptoms of experimental PD were observed. These findings support the interpretation that the retina is involved in the control of motor function and in the aetiology of PD. |
| doi_str_mv | 10.1038/srep03921 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5379242</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1897802836</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-bbec7bb47a5f4dae4aa476594726bfac25dc1615fb625916ef451b03de69d8903</originalsourceid><addsrcrecordid>eNplkE9Lw0AQxRdRbKk9-AUk4EEUo_s3yXoQtFoVIoroedkkkza17tbdVOi3d6W1VJzLDLwfbx4PoX2Czwhm2bl3MMNMUrKFuhRzEVNG6fbG3UF97yc4jKCSE7mLOpTzlGHJumj4rN17Y7w1Rz66aTxoD6dR3ozGrY-0qaJHmGpjy0UL_iLKrQ3wKLqGhQ1aO4boBdrG6D20U-uph_5q99Db8PZ1cB_nT3cPg6s8LjnL2rgooEyLgqda1LzSwLXmaSIkT2lS1LqkoipJQkRdJFRIkkDNBSkwqyCRVSYx66HLpe9sXnxAVYJpnZ6qmWs-tFsoqxv1VzHNWI3slxIslZTTYHC4MnD2cw6-VRM7dyZkViSTaYZpxpJAHS-p0lkfCq7XHwhWP62rdeuBPdiMtCZ_Ow7AyRLwQTIjcBsv_7l9A62ci-Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1897802836</pqid></control><display><type>article</type><title>Parkinson's Disease, Lights and Melanocytes: Looking Beyond the Retina</title><source>MEDLINE</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Willis, Gregory L. ; Moore, Cleo ; Armstrong, Stuart Maxwell</creator><creatorcontrib>Willis, Gregory L. ; Moore, Cleo ; Armstrong, Stuart Maxwell</creatorcontrib><description>Critical analysis of recent research suggesting that light pollution causes Parkinson's disease (PD) reveals that such a hypothesis is unsustainable in the context of therapeutic use of light in treating various neuropsychiatric conditions. Reinterpretation of their findings suggests that retinal damage caused by prolonged light exposure may have contributed to the observed enhancement of experimental PD. To test this hypothesis further, forty-two Sprague Dawley rats received microinjections of 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-2, 4, 6-tetrahydropyridine (MPTP), paraquat or rotenone into the vitreal mass in doses so minute that the effects could not be attributed to diffusion into brain. Significant changes in five motor parameters consistent with symptoms of experimental PD were observed. These findings support the interpretation that the retina is involved in the control of motor function and in the aetiology of PD.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep03921</identifier><identifier>PMID: 24473093</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology ; 6-Hydroxydopamine ; 631/378 ; 631/378/1689/1718 ; 631/378/2632/1323 ; 64 ; 64/86 ; 692/420 ; Animals ; Disease Models, Animal ; Female ; Humanities and Social Sciences ; Hypotheses ; Light ; Light sources ; Male ; Melanocytes ; Melanocytes - drug effects ; Melanocytes - physiology ; Motor Activity - drug effects ; Motor Activity - physiology ; Motor task performance ; Movement disorders ; MPTP ; multidisciplinary ; Neurodegenerative diseases ; Oxidopamine - pharmacology ; Paraquat ; Paraquat - pharmacology ; Parkinson Disease - physiopathology ; Parkinson's disease ; Rats ; Rats, Sprague-Dawley ; Retina ; Retina - drug effects ; Retina - physiopathology ; Rotenone ; Rotenone - pharmacology ; Science</subject><ispartof>Scientific reports, 2014-01, Vol.4 (1), p.3921, Article 3921</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Jan 2014</rights><rights>Copyright © 2014, Macmillan Publishers Limited. All rights reserved 2014 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-bbec7bb47a5f4dae4aa476594726bfac25dc1615fb625916ef451b03de69d8903</citedby><cites>FETCH-LOGICAL-c438t-bbec7bb47a5f4dae4aa476594726bfac25dc1615fb625916ef451b03de69d8903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379242/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379242/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24473093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Willis, Gregory L.</creatorcontrib><creatorcontrib>Moore, Cleo</creatorcontrib><creatorcontrib>Armstrong, Stuart Maxwell</creatorcontrib><title>Parkinson's Disease, Lights and Melanocytes: Looking Beyond the Retina</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Critical analysis of recent research suggesting that light pollution causes Parkinson's disease (PD) reveals that such a hypothesis is unsustainable in the context of therapeutic use of light in treating various neuropsychiatric conditions. Reinterpretation of their findings suggests that retinal damage caused by prolonged light exposure may have contributed to the observed enhancement of experimental PD. To test this hypothesis further, forty-two Sprague Dawley rats received microinjections of 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-2, 4, 6-tetrahydropyridine (MPTP), paraquat or rotenone into the vitreal mass in doses so minute that the effects could not be attributed to diffusion into brain. Significant changes in five motor parameters consistent with symptoms of experimental PD were observed. These findings support the interpretation that the retina is involved in the control of motor function and in the aetiology of PD.</description><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology</subject><subject>6-Hydroxydopamine</subject><subject>631/378</subject><subject>631/378/1689/1718</subject><subject>631/378/2632/1323</subject><subject>64</subject><subject>64/86</subject><subject>692/420</subject><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Hypotheses</subject><subject>Light</subject><subject>Light sources</subject><subject>Male</subject><subject>Melanocytes</subject><subject>Melanocytes - drug effects</subject><subject>Melanocytes - physiology</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Motor task performance</subject><subject>Movement disorders</subject><subject>MPTP</subject><subject>multidisciplinary</subject><subject>Neurodegenerative diseases</subject><subject>Oxidopamine - pharmacology</subject><subject>Paraquat</subject><subject>Paraquat - pharmacology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Retina</subject><subject>Retina - drug effects</subject><subject>Retina - physiopathology</subject><subject>Rotenone</subject><subject>Rotenone - pharmacology</subject><subject>Science</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkE9Lw0AQxRdRbKk9-AUk4EEUo_s3yXoQtFoVIoroedkkkza17tbdVOi3d6W1VJzLDLwfbx4PoX2Czwhm2bl3MMNMUrKFuhRzEVNG6fbG3UF97yc4jKCSE7mLOpTzlGHJumj4rN17Y7w1Rz66aTxoD6dR3ozGrY-0qaJHmGpjy0UL_iLKrQ3wKLqGhQ1aO4boBdrG6D20U-uph_5q99Db8PZ1cB_nT3cPg6s8LjnL2rgooEyLgqda1LzSwLXmaSIkT2lS1LqkoipJQkRdJFRIkkDNBSkwqyCRVSYx66HLpe9sXnxAVYJpnZ6qmWs-tFsoqxv1VzHNWI3slxIslZTTYHC4MnD2cw6-VRM7dyZkViSTaYZpxpJAHS-p0lkfCq7XHwhWP62rdeuBPdiMtCZ_Ow7AyRLwQTIjcBsv_7l9A62ci-Q</recordid><startdate>20140129</startdate><enddate>20140129</enddate><creator>Willis, Gregory L.</creator><creator>Moore, Cleo</creator><creator>Armstrong, Stuart Maxwell</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20140129</creationdate><title>Parkinson's Disease, Lights and Melanocytes: Looking Beyond the Retina</title><author>Willis, Gregory L. ; Moore, Cleo ; Armstrong, Stuart Maxwell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-bbec7bb47a5f4dae4aa476594726bfac25dc1615fb625916ef451b03de69d8903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology</topic><topic>6-Hydroxydopamine</topic><topic>631/378</topic><topic>631/378/1689/1718</topic><topic>631/378/2632/1323</topic><topic>64</topic><topic>64/86</topic><topic>692/420</topic><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Hypotheses</topic><topic>Light</topic><topic>Light sources</topic><topic>Male</topic><topic>Melanocytes</topic><topic>Melanocytes - drug effects</topic><topic>Melanocytes - physiology</topic><topic>Motor Activity - drug effects</topic><topic>Motor Activity - physiology</topic><topic>Motor task performance</topic><topic>Movement disorders</topic><topic>MPTP</topic><topic>multidisciplinary</topic><topic>Neurodegenerative diseases</topic><topic>Oxidopamine - pharmacology</topic><topic>Paraquat</topic><topic>Paraquat - pharmacology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Retina</topic><topic>Retina - drug effects</topic><topic>Retina - physiopathology</topic><topic>Rotenone</topic><topic>Rotenone - pharmacology</topic><topic>Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Willis, Gregory L.</creatorcontrib><creatorcontrib>Moore, Cleo</creatorcontrib><creatorcontrib>Armstrong, Stuart Maxwell</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Willis, Gregory L.</au><au>Moore, Cleo</au><au>Armstrong, Stuart Maxwell</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parkinson's Disease, Lights and Melanocytes: Looking Beyond the Retina</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2014-01-29</date><risdate>2014</risdate><volume>4</volume><issue>1</issue><spage>3921</spage><pages>3921-</pages><artnum>3921</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Critical analysis of recent research suggesting that light pollution causes Parkinson's disease (PD) reveals that such a hypothesis is unsustainable in the context of therapeutic use of light in treating various neuropsychiatric conditions. Reinterpretation of their findings suggests that retinal damage caused by prolonged light exposure may have contributed to the observed enhancement of experimental PD. To test this hypothesis further, forty-two Sprague Dawley rats received microinjections of 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-2, 4, 6-tetrahydropyridine (MPTP), paraquat or rotenone into the vitreal mass in doses so minute that the effects could not be attributed to diffusion into brain. Significant changes in five motor parameters consistent with symptoms of experimental PD were observed. These findings support the interpretation that the retina is involved in the control of motor function and in the aetiology of PD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24473093</pmid><doi>10.1038/srep03921</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2014-01, Vol.4 (1), p.3921, Article 3921 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5379242 |
| source | MEDLINE; Springer Nature OA Free Journals; Nature Free; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology 6-Hydroxydopamine 631/378 631/378/1689/1718 631/378/2632/1323 64 64/86 692/420 Animals Disease Models, Animal Female Humanities and Social Sciences Hypotheses Light Light sources Male Melanocytes Melanocytes - drug effects Melanocytes - physiology Motor Activity - drug effects Motor Activity - physiology Motor task performance Movement disorders MPTP multidisciplinary Neurodegenerative diseases Oxidopamine - pharmacology Paraquat Paraquat - pharmacology Parkinson Disease - physiopathology Parkinson's disease Rats Rats, Sprague-Dawley Retina Retina - drug effects Retina - physiopathology Rotenone Rotenone - pharmacology Science |
| title | Parkinson's Disease, Lights and Melanocytes: Looking Beyond the Retina |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T07%3A24%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Parkinson's%20Disease,%20Lights%20and%20Melanocytes:%20Looking%20Beyond%20the%20Retina&rft.jtitle=Scientific%20reports&rft.au=Willis,%20Gregory%20L.&rft.date=2014-01-29&rft.volume=4&rft.issue=1&rft.spage=3921&rft.pages=3921-&rft.artnum=3921&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep03921&rft_dat=%3Cproquest_pubme%3E1897802836%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1897802836&rft_id=info:pmid/24473093&rfr_iscdi=true |