Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens

Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this immunity are not well-understood. We used HER2 as a model immunogen and reverse-engineered mu...

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Veröffentlicht in:	Scientific reports 2015-07, Vol.5 (1), p.12411-12411, Article 12411
Hauptverfasser:	Chen, Hong-Sen, Hou, Shin-Chen, Jian, Jhih-Wei, Goh, King-Siang, Shen, San-Tai, Lee, Yu-Ching, You, Jhong-Jhe, Peng, Hung-Pin, Kuo, Wen-Chih, Chen, Shui-Tsung, Peng, Ming-Chi, Wang, Andrew H.-J., Yu, Chung-Ming, Chen, Ing-Chien, Tung, Chao-Ping, Chen, Tzu-Han, Ping Chiu, Kuo, Ma, Che, Yuan Wu, Chih, Lin, Sheng-Wei, Yang, An-Suei
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 45 45/47 49/1 49/23 631/1647/2163 631/1647/514/2254 631/61/338/469 631/92/605 82 82/1 82/47 Affinity Amino Acid Sequence Animals Antibodies Antibody libraries Antibody response Antigen-Antibody Reactions - immunology Antigens Binding Sites ErbB-2 protein Humanities and Social Sciences Humans Humoral immunity Immunity, Innate - immunology Immunoglobulins Mice Molecular Sequence Data multidisciplinary Next-generation sequencing Phages Protein Binding Receptor, ErbB-2 - chemistry Receptor, ErbB-2 - immunology Science Structure-Activity Relationship Vaccines
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