FKBP51 regulates cell motility and invasion via RhoA signaling

FK506 binding protein 51 (FKBP51), a member of the immunophilin family, is involved in multiple signaling pathways, tumorigenesis, and chemoresistance. FKBP51 expression correlates with metastatic potential in melanoma and prostate cancer. However, the functions of FKBP51, particularly involving the...

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Veröffentlicht in:	Cancer science 2017-03, Vol.108 (3), p.380-389
Hauptverfasser:	Takaoka, Miho, Ito, Shun, Miki, Yoshio, Nakanishi, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Androgens Cell Line, Tumor Cell migration Cell Movement - genetics Cell Movement - physiology Chemoresistance Cortex Cytoskeleton Deleted in liver cancer 1 deleted in liver cancer 2 Filaments FKBP51 GTPase-Activating Proteins - metabolism Guanosine triphosphatases HEK293 Cells Humans Immunoglobulins Immunoprecipitation Kinases Liver cancer Mass Spectrometry Mass spectroscopy MCF-7 Cells Melanoma Metastases Metastasis Motility Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Original Peptides Phenotypes Prostate cancer Proteins rho-Associated Kinases - metabolism RhoA rhoA GTP-Binding Protein - metabolism RhoA protein RNA Interference RNA, Small Interfering - genetics ROCK Scientific imaging Signal transduction Signal Transduction - physiology Studies Tacrolimus Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism Tacrolimus-binding protein Tumor Suppressor Proteins - metabolism Tumorigenesis
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