Tumor‐derived spheroids: Relevance to cancer stem cells and clinical applications

Recently, many types of in vitro 3‐D culture systems have been developed to recapitulate the in vivo growth conditions of cancer. The cancer 3‐D culture methods aim to preserve the biological characteristics of original tumors better than conventional 2‐D monolayer cultures, and include tumor‐derive...

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Veröffentlicht in:	Cancer science 2017-03, Vol.108 (3), p.283-289
Hauptverfasser:	Ishiguro, Tatsuya, Ohata, Hirokazu, Sato, Ai, Yamawaki, Kaoru, Enomoto, Takayuki, Okamoto, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemical characteristics Body fluids Brain tumors Breast Cancer Cancer stem cell Cell adhesion & migration Cell culture Cell Culture Techniques Chemoresistance Colon Genetic engineering Glioma Growth conditions Humans Investigations Kinases Menopause Methods Multicellular tumor spheroids Neoplasms - pathology Neoplastic Stem Cells - cytology Neoplastic Stem Cells - pathology Organoids Ovarian cancer Prostate cancer R&D Research & development Review solid tumor Solid tumors Spheres Spheroids Spheroids, Cellular - cytology Spheroids, Cellular - pathology Stem cells Therapeutic applications three‐dimensional culture Tumor cells Tumor Cells, Cultured Tumorigenicity Tumors tumor‐derived spheroid
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