Soft Selective Sweeps in Evolutionary Rescue
Evolutionary rescue occurs when a population that is declining in size because of an environmental change is rescued from extinction by genetic adaptation. Evolutionary rescue is an important phenomenon at the intersection of ecology and population genetics, and the study of evolutionary rescue is c...
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| Veröffentlicht in: | Genetics (Austin) 2017-04, Vol.205 (4), p.1573-1586 |
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| creator | Wilson, Benjamin A Pennings, Pleuni S Petrov, Dmitri A |
| description | Evolutionary rescue occurs when a population that is declining in size because of an environmental change is rescued from extinction by genetic adaptation. Evolutionary rescue is an important phenomenon at the intersection of ecology and population genetics, and the study of evolutionary rescue is critical to understanding processes ranging from species conservation to the evolution of drug and pesticide resistance. While most population-genetic models of evolutionary rescue focus on estimating the probability of rescue, we focus on whether one or more adaptive lineages contribute to evolutionary rescue. We find that when evolutionary rescue is likely, it is often driven by soft selective sweeps where multiple adaptive mutations spread through the population simultaneously. We give full analytic results for the probability of evolutionary rescue and the probability that evolutionary rescue occurs via soft selective sweeps. We expect that these results will find utility in understanding the genetic signatures associated with various evolutionary rescue scenarios in large populations, such as the evolution of drug resistance in viral, bacterial, or eukaryotic pathogens. |
| doi_str_mv | 10.1534/genetics.116.191478 |
| format | Article |
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Evolutionary rescue is an important phenomenon at the intersection of ecology and population genetics, and the study of evolutionary rescue is critical to understanding processes ranging from species conservation to the evolution of drug and pesticide resistance. While most population-genetic models of evolutionary rescue focus on estimating the probability of rescue, we focus on whether one or more adaptive lineages contribute to evolutionary rescue. We find that when evolutionary rescue is likely, it is often driven by soft selective sweeps where multiple adaptive mutations spread through the population simultaneously. We give full analytic results for the probability of evolutionary rescue and the probability that evolutionary rescue occurs via soft selective sweeps. 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Evolutionary rescue is an important phenomenon at the intersection of ecology and population genetics, and the study of evolutionary rescue is critical to understanding processes ranging from species conservation to the evolution of drug and pesticide resistance. While most population-genetic models of evolutionary rescue focus on estimating the probability of rescue, we focus on whether one or more adaptive lineages contribute to evolutionary rescue. We find that when evolutionary rescue is likely, it is often driven by soft selective sweeps where multiple adaptive mutations spread through the population simultaneously. We give full analytic results for the probability of evolutionary rescue and the probability that evolutionary rescue occurs via soft selective sweeps. We expect that these results will find utility in understanding the genetic signatures associated with various evolutionary rescue scenarios in large populations, such as the evolution of drug resistance in viral, bacterial, or eukaryotic pathogens.</description><subject>Adaptation</subject><subject>Adaptation, Physiological - genetics</subject><subject>Climate change</subject><subject>Demographics</subject><subject>Demography</subject><subject>Drug resistance</subject><subject>Evolution, Molecular</subject><subject>Genetic diversity</subject><subject>Genetic Fitness</subject><subject>Investigations</subject><subject>Models, Genetic</subject><subject>Mutation</subject><subject>Population decline</subject><subject>Probability</subject><subject>Selection, Genetic</subject><subject>Simulation</subject><issn>1943-2631</issn><issn>0016-6731</issn><issn>1943-2631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkctKAzEUhoMotlafQJABNy5szUkyuWwEKfUCBcHqOsykp3XKdFInMxXf3qm9UF25SiDf-flPPkLOgfYg5uJmigVWmQs9ANkDA0LpA9IGI3iXSQ6He_cWOQlhRimVJtbHpMU0Ay6UapPrkZ9U0QhzdFW2xGj0ibgIUVZEg6XP6yrzRVJ-RS8YXI2n5GiS5AHPNmeHvN0PXvuP3eHzw1P_bth1QsqqCyaWMnHIUKXINFJIaarMWEkBVOuxkEYy6YDHDlOWoAbueBq7CR2vSnHeIbfr3EWdznHssKjKJLeLMps3ZaxPMvv7pcje7dQvbcyVBhBNwNUmoPQfNYbKzrPgMM-TAn0dLGgDWotYwT9QaYyUAKxBL_-gM1-XRfMTDaUNV5T9UHxNudKHUOJk1xuoXYmzW3G2EWfX4pqpi_2VdzNbU_wbfmaU4g</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Wilson, Benjamin A</creator><creator>Pennings, Pleuni S</creator><creator>Petrov, Dmitri A</creator><general>Genetics Society of America</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7QP</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3992-2876</orcidid><orcidid>https://orcid.org/0000-0002-3664-9130</orcidid><orcidid>https://orcid.org/0000-0001-8704-6578</orcidid></search><sort><creationdate>20170401</creationdate><title>Soft Selective Sweeps in Evolutionary Rescue</title><author>Wilson, Benjamin A ; Pennings, Pleuni S ; Petrov, Dmitri A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-19566ace2e7be28e01b0b79d7641088d469626c135ceb2ae813c3b5cf0d347733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adaptation</topic><topic>Adaptation, Physiological - genetics</topic><topic>Climate change</topic><topic>Demographics</topic><topic>Demography</topic><topic>Drug resistance</topic><topic>Evolution, Molecular</topic><topic>Genetic diversity</topic><topic>Genetic Fitness</topic><topic>Investigations</topic><topic>Models, Genetic</topic><topic>Mutation</topic><topic>Population decline</topic><topic>Probability</topic><topic>Selection, Genetic</topic><topic>Simulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, Benjamin A</creatorcontrib><creatorcontrib>Pennings, Pleuni S</creatorcontrib><creatorcontrib>Petrov, Dmitri A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genetics (Austin)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, Benjamin A</au><au>Pennings, Pleuni S</au><au>Petrov, Dmitri A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soft Selective Sweeps in Evolutionary Rescue</atitle><jtitle>Genetics (Austin)</jtitle><addtitle>Genetics</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>205</volume><issue>4</issue><spage>1573</spage><epage>1586</epage><pages>1573-1586</pages><issn>1943-2631</issn><issn>0016-6731</issn><eissn>1943-2631</eissn><coden>GENTAE</coden><abstract>Evolutionary rescue occurs when a population that is declining in size because of an environmental change is rescued from extinction by genetic adaptation. Evolutionary rescue is an important phenomenon at the intersection of ecology and population genetics, and the study of evolutionary rescue is critical to understanding processes ranging from species conservation to the evolution of drug and pesticide resistance. While most population-genetic models of evolutionary rescue focus on estimating the probability of rescue, we focus on whether one or more adaptive lineages contribute to evolutionary rescue. We find that when evolutionary rescue is likely, it is often driven by soft selective sweeps where multiple adaptive mutations spread through the population simultaneously. We give full analytic results for the probability of evolutionary rescue and the probability that evolutionary rescue occurs via soft selective sweeps. We expect that these results will find utility in understanding the genetic signatures associated with various evolutionary rescue scenarios in large populations, such as the evolution of drug resistance in viral, bacterial, or eukaryotic pathogens.</abstract><cop>United States</cop><pub>Genetics Society of America</pub><pmid>28213477</pmid><doi>10.1534/genetics.116.191478</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-3992-2876</orcidid><orcidid>https://orcid.org/0000-0002-3664-9130</orcidid><orcidid>https://orcid.org/0000-0001-8704-6578</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1943-2631 |
| ispartof | Genetics (Austin), 2017-04, Vol.205 (4), p.1573-1586 |
| issn | 1943-2631 0016-6731 1943-2631 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5378114 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adaptation Adaptation, Physiological - genetics Climate change Demographics Demography Drug resistance Evolution, Molecular Genetic diversity Genetic Fitness Investigations Models, Genetic Mutation Population decline Probability Selection, Genetic Simulation |
| title | Soft Selective Sweeps in Evolutionary Rescue |
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