Gastric Proteins MUC5AC and TFF1 as Potential Diagnostic Markers of Colonic Sessile Serrated Adenomas/Polyps

Gastric Proteins MUC5AC and TFF1 as Potential Diagnostic Markers of Colonic Sessile Serrated Adenomas/Polyps

Objectives: A subset of colon cancers originates from sessile serrated adenomas/polyps (SSA/Ps). Our goal was to identify markers for SSA/Ps that could aid in distinguishing them from hyperplastic polyps (HPs). Methods: We performed immunostaining for gastric proteins MUC5AC and TFF1 in formalin-fix...

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Veröffentlicht in:American journal of clinical pathology 2016-11, Vol.146 (5), p.530-537
Hauptverfasser: Khaidakov, Magomed, Lai, Keith K., Roudachevski, D., Sargsyan, Julietta, Goyne, Hannah E., Pai, Rish K., Lamps, Laura W., Hagedorn, Curt H.
Format: Artikel
Sprache:eng
Schlagworte:
Adenoma - diagnosis
Adenoma - metabolism
Adenoma - pathology
Biomarkers, Tumor - analysis
Colon - metabolism
Colon - pathology
Colonic Neoplasms - diagnosis
Colonic Neoplasms - metabolism
Colonic Neoplasms - pathology
Colonic Polyps - diagnosis
Colonic Polyps - metabolism
Colonic Polyps - pathology
Colorectal cancer
Diagnosis, Differential
Humans
Humidity
Hyperplasia - diagnosis
Hyperplasia - metabolism
Hyperplasia - pathology
Immunohistochemistry
Kinases
Medical diagnosis
Medical screening
Mucin 5AC - analysis
Mutation
Original
Pancreatic cancer
Polyps
Proteins
Trefoil Factor-1 - analysis
Tumors
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Zusammenfassung:Objectives: A subset of colon cancers originates from sessile serrated adenomas/polyps (SSA/Ps). Our goal was to identify markers for SSA/Ps that could aid in distinguishing them from hyperplastic polyps (HPs). Methods: We performed immunostaining for gastric proteins MUC5AC and TFF1 in formalin-fixed, paraffin-embedded (FFPE) samples of HPs (n = 47), SSA/Ps (n = 37), and normal colon (n = 30). Results: Control mucosa expressed only trace amounts of MUC5AC and TFF1. HPs exhibited an 11.3- and 11.4-fold increase in MUC5AC and TFF1 expression confined to the upper segments of the crypts near the luminal surface of the polyps. SSA/Ps displayed on average 1.6-fold (MUC5AC, P 
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/aqw142