Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors

LPS-mediated activation of Toll-like receptor 4 (TLR4) in macrophages results in the coordinated release of proinflammatory cytokines, followed by regulatory mediators, to ensure that this potentially destructive pathway is tightly regulated. We showed previously that Rab8a recruits PI3Kγ for Akt-de...

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Veröffentlicht in:	The Journal of biological chemistry 2017-03, Vol.292 (11), p.4411-4422
Hauptverfasser:	Wall, Adam A., Luo, Lin, Hung, Yu, Tong, Samuel J., Condon, Nicholas D., Blumenthal, Antje, Sweet, Matthew J., Stow, Jennifer L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt PKB Animals Cell Biology Cells, Cultured Class Ib Phosphatidylinositol 3-Kinase - immunology Cytokines - immunology Female Humans inflammation innate immunity macrophage Macrophages - cytology Macrophages - immunology macropinocytosis Male mammalian target of rapamycin (mTOR) Mice Mice, Inbred C57BL Phosphatidylinositol Phosphates - analysis Phosphatidylinositol Phosphates - immunology PI3K Rab rab GTP-Binding Proteins - analysis rab GTP-Binding Proteins - immunology Rab8 RAW 264.7 Cells Signal Transduction Toll-like receptor (TLR) Toll-Like Receptors - analysis Toll-Like Receptors - immunology
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