Circulatory dose-response effects of hydrochlorothiazide at rest and during dynamic exercise in essential hypertension
The immediate and sustained circulatory effects of hydrochlorothiazide were evaluated at rest and during dynamic exercise in 24 patients with essential hypertension. Twenty-four hours after the first dose (50mg) there was a reduction in the resting systolic blood pressure, with attenuation of exerci...
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| Veröffentlicht in: | Journal of the Royal College of Physicians of London 1982-10, Vol.16 (4), p.232-235 |
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| creator | Kumar, E B Nelson, G I Silke, B Ahuja, R C Okoli, R C Taylor, S H |
| description | The immediate and sustained circulatory effects of hydrochlorothiazide were evaluated at rest and during dynamic exercise in 24 patients with essential hypertension. Twenty-four hours after the first dose (50mg) there was a reduction in the resting systolic blood pressure, with attenuation of exercise tachycardia. During sustained therapy at two dose levels (50mg and 100mg), each of one month's duration, the systolic and diastolic blood pressure were reduced, both at rest and during dynamic exercise, without substantial difference between the two doses. Exercise tachycardia was attenuated during longterm treatment, without alteration of the pressor responses to exercise. The reduction in exercise tachycardia at the same workload in this study suggests that thiazides, in addition to their diuretic action, have a vascular component that augments the fall in systemic vascular resistance during dynamic exercise. |
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Twenty-four hours after the first dose (50mg) there was a reduction in the resting systolic blood pressure, with attenuation of exercise tachycardia. During sustained therapy at two dose levels (50mg and 100mg), each of one month's duration, the systolic and diastolic blood pressure were reduced, both at rest and during dynamic exercise, without substantial difference between the two doses. Exercise tachycardia was attenuated during longterm treatment, without alteration of the pressor responses to exercise. 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Twenty-four hours after the first dose (50mg) there was a reduction in the resting systolic blood pressure, with attenuation of exercise tachycardia. During sustained therapy at two dose levels (50mg and 100mg), each of one month's duration, the systolic and diastolic blood pressure were reduced, both at rest and during dynamic exercise, without substantial difference between the two doses. Exercise tachycardia was attenuated during longterm treatment, without alteration of the pressor responses to exercise. The reduction in exercise tachycardia at the same workload in this study suggests that thiazides, in addition to their diuretic action, have a vascular component that augments the fall in systemic vascular resistance during dynamic exercise.</abstract><cop>England</cop><pub>Royal College of Physicians of London</pub><pmid>7143288</pmid><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the Royal College of Physicians of London, 1982-10, Vol.16 (4), p.232-235 |
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| subjects | Adult Blood Pressure - drug effects Dose-Response Relationship, Drug Heart Rate - drug effects Hemodynamics - drug effects Humans Hydrochlorothiazide - pharmacology Hypertension - drug therapy Hypertension - physiopathology Male Middle Aged Physical Exertion Rest |
| title | Circulatory dose-response effects of hydrochlorothiazide at rest and during dynamic exercise in essential hypertension |
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