Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation

O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclea...

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Veröffentlicht in:	Scientific reports 2017-04, Vol.7 (1), p.44921-44921, Article 44921
Hauptverfasser:	Yang, Yong Ryoul, Song, Seungju, Hwang, Hongik, Jung, Jung Hoon, Kim, Su-Jeong, Yoon, Sora, Hur, Jin-Hoe, Park, Jae-Il, Lee, Cheol, Nam, Dougu, Seo, Young-Kyo, Kim, Joung-Hun, Rhim, Hyewhon, Suh, Pann-Ghill
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 38/1 38/39 631/378/1595/3922 631/378/2591/2592 64/60 82/80 9/30 9/74 Heterozygosity Hippocampal plasticity Hippocampus Humanities and Social Sciences Long-term depression Long-term potentiation multidisciplinary Neurodegenerative diseases O-GlcNAcylation Phosphorylation Plasticity Rodents Science Spatial discrimination learning Spatial memory Synaptic plasticity α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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