The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression

The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, regulates the mRNA elongation capacity of RNA polymerase II (RNAPII) through controlling the nuclear activity of positive transcription elongation factor b (P‐TEFb). Here, we demonstrate that the huma...

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Veröffentlicht in:	The EMBO journal 2017-04, Vol.36 (7), p.934-948
Hauptverfasser:	Egloff, Sylvain, Vitali, Patrice, Tellier, Michael, Raffel, Raoul, Murphy, Shona, Kiss, Tamás
Format:	Artikel
Sprache:	eng
Schlagworte:	7SK snRNP Chromatin Immunoprecipitation EMBO36 EMBO44 Gene expression Gene Expression Regulation HeLa Cells Humans Life Sciences little elongation complex regulatory RNA Ribonucleoproteins - metabolism RNA polymerase RNA polymerase II RNA Polymerase II - metabolism RNA, Small Nuclear - biosynthesis snRNA gene transcription Transcription Factors - metabolism
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