Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer?
Colorectal cancer (CRC) was one of the most frequent cancers worldwide. Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion con...
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| Veröffentlicht in: | Disease markers 2017-01, Vol.2017 (2017), p.1-9 |
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| creator | Shuwen, Han Yuefen, Pan Xi, Yang |
| description | Colorectal cancer (CRC) was one of the most frequent cancers worldwide. Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion contains its own DNA and regulates self-replicating so that it can be as a candidate biomarker for evaluating the risk and prognosis of colorectal cancer. But there were already huge controversies on this issue. The review was to summarize current viewpoints of the controversial issues and described our understanding from the four aspects including mtDNA copy number, mitochondrial displacement loop, mtDNA variation, and mtDNA microsatellite instability, wishing the summary of the mtDNA in colorectal cancer could provide a meaningful reference or a valuable direction in the future studies. |
| doi_str_mv | 10.1155/2017/5189803 |
| format | Article |
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Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion contains its own DNA and regulates self-replicating so that it can be as a candidate biomarker for evaluating the risk and prognosis of colorectal cancer. But there were already huge controversies on this issue. The review was to summarize current viewpoints of the controversial issues and described our understanding from the four aspects including mtDNA copy number, mitochondrial displacement loop, mtDNA variation, and mtDNA microsatellite instability, wishing the summary of the mtDNA in colorectal cancer could provide a meaningful reference or a valuable direction in the future studies.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2017/5189803</identifier><identifier>PMID: 28408773</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Analysis ; Biological markers ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Colorectal cancer ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; DNA ; DNA Copy Number Variations ; DNA, Mitochondrial - genetics ; DNA, Mitochondrial - metabolism ; Genetic aspects ; Health aspects ; Health risk assessment ; Humans ; Microsatellite Instability ; Microsatellite Repeats ; Mitochondria ; Mitochondria - genetics ; Mitochondria - metabolism ; Nucleic Acid Conformation ; Prognosis ; Review ; Risk ; Risk Assessment ; Risk factors ; Survival Analysis</subject><ispartof>Disease markers, 2017-01, Vol.2017 (2017), p.1-9</ispartof><rights>Copyright © 2017 Han Shuwen et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Han Shuwen et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-29ef5ba3677ce075606029e3b80a5ffe293395a3c1de03dac0d842167778f793</citedby><cites>FETCH-LOGICAL-c471t-29ef5ba3677ce075606029e3b80a5ffe293395a3c1de03dac0d842167778f793</cites><orcidid>0000-0001-6363-6231</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376434/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376434/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28408773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Jin, Hong C.</contributor><creatorcontrib>Shuwen, Han</creatorcontrib><creatorcontrib>Yuefen, Pan</creatorcontrib><creatorcontrib>Xi, Yang</creatorcontrib><title>Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer?</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Colorectal cancer (CRC) was one of the most frequent cancers worldwide. Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion contains its own DNA and regulates self-replicating so that it can be as a candidate biomarker for evaluating the risk and prognosis of colorectal cancer. But there were already huge controversies on this issue. The review was to summarize current viewpoints of the controversial issues and described our understanding from the four aspects including mtDNA copy number, mitochondrial displacement loop, mtDNA variation, and mtDNA microsatellite instability, wishing the summary of the mtDNA in colorectal cancer could provide a meaningful reference or a valuable direction in the future studies.</description><subject>Analysis</subject><subject>Biological markers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>DNA</subject><subject>DNA Copy Number Variations</subject><subject>DNA, Mitochondrial - genetics</subject><subject>DNA, Mitochondrial - metabolism</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Microsatellite Instability</subject><subject>Microsatellite Repeats</subject><subject>Mitochondria</subject><subject>Mitochondria - genetics</subject><subject>Mitochondria - metabolism</subject><subject>Nucleic Acid Conformation</subject><subject>Prognosis</subject><subject>Review</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><subject>Survival Analysis</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqN0c1vFCEYBnBiNHZbvXk2JF5M6toXGAbmUrOu9SOp1ZjeCcu87NLOQoXZNf73stm16s3TJMyPB14eQp4xeM2YlGccmDqTTHcaxAMyYVrJqW4FPCQT4EpPgTdwRI5LuQFgvGu6x-SI6wa0UmJCbuY20s9hTG6VYp-Dpe-uZvRrTtvQI7X0Km1xoG9DWtt8i5n6lOnF1g4bO4a4pOMK6bdQbqmN_W7XMqYSCk2eztOQMrrRDrQe4TC_eUIeeTsUfHr4npDr9xfX84_Tyy8fPs1nl1PXKDZOeYdeLqxolXIISrbQQl0TCw1Weo-8E6KTVjjWI4jeOuh1w1nlSnvViRNyvo-92yzW2DuMY7aDucuhjvDTJBvMv39iWJll2hopVNuIpga8PATk9H2DZTTrUBwOg42YNsUwrXWrOZNQ6Ys9XdoBTYg-1US342YmZX1vCVxX9WqvXE6lZPT3l2Fgdh2aXYfm0GHlz_8e4B7_Lq2C0z1YhdjbH-E_47Aa9PaPZpKLOvEvlJOsxg</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Shuwen, Han</creator><creator>Yuefen, Pan</creator><creator>Xi, Yang</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6363-6231</orcidid></search><sort><creationdate>20170101</creationdate><title>Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer?</title><author>Shuwen, Han ; Yuefen, Pan ; Xi, Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-29ef5ba3677ce075606029e3b80a5ffe293395a3c1de03dac0d842167778f793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Analysis</topic><topic>Biological markers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>DNA</topic><topic>DNA Copy Number Variations</topic><topic>DNA, Mitochondrial - genetics</topic><topic>DNA, Mitochondrial - metabolism</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Microsatellite Instability</topic><topic>Microsatellite Repeats</topic><topic>Mitochondria</topic><topic>Mitochondria - genetics</topic><topic>Mitochondria - metabolism</topic><topic>Nucleic Acid Conformation</topic><topic>Prognosis</topic><topic>Review</topic><topic>Risk</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shuwen, Han</creatorcontrib><creatorcontrib>Yuefen, Pan</creatorcontrib><creatorcontrib>Xi, Yang</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shuwen, Han</au><au>Yuefen, Pan</au><au>Xi, Yang</au><au>Jin, Hong C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer?</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Colorectal cancer (CRC) was one of the most frequent cancers worldwide. Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion contains its own DNA and regulates self-replicating so that it can be as a candidate biomarker for evaluating the risk and prognosis of colorectal cancer. But there were already huge controversies on this issue. The review was to summarize current viewpoints of the controversial issues and described our understanding from the four aspects including mtDNA copy number, mitochondrial displacement loop, mtDNA variation, and mtDNA microsatellite instability, wishing the summary of the mtDNA in colorectal cancer could provide a meaningful reference or a valuable direction in the future studies.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28408773</pmid><doi>10.1155/2017/5189803</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6363-6231</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Biological markers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology DNA DNA Copy Number Variations DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Genetic aspects Health aspects Health risk assessment Humans Microsatellite Instability Microsatellite Repeats Mitochondria Mitochondria - genetics Mitochondria - metabolism Nucleic Acid Conformation Prognosis Review Risk Risk Assessment Risk factors Survival Analysis |
| title | Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer? |
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