Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2‑Amino-1-methyl-6-phenylimidazo[4,5‑b]pyridine and Albumin in Humans

2-Amino-1-methyl-6-phenylimidazo­[4,5-b]­pyridine (PhIP) is a carcinogenic heterocyclic aromatic amine formed during the high-temperature cooking of meats. The cytochrome P450-mediated N-hydroxylation of the exocyclic amine group of PhIP produces 2-hydroxyamino-1-methyl-6-phenylimidazo­[4,5-b]­pyrid...

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Veröffentlicht in:	Chemical research in toxicology 2017-02, Vol.30 (2), p.705-714
Hauptverfasser:	Wang, Yi, Villalta, Peter W, Peng, Lijuan, Dingley, Karen, Malfatti, Michael A, Turteltaub, K. W, Turesky, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - metabolism Calibration Chromatography, Liquid - methods Humans Hydrolysis Imidazoles - metabolism Mass Spectrometry - methods
Online-Zugang:	Volltext
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