Exposure to Ambient Particulate Matter Induced COPD in a Rat Model and a Description of the Underlying Mechanism
While the health effects of air pollution have been an international public health concern since at least the 1950s, recent research has focused on two broad sources of air pollution, namely, biomass fuel (BMF) and motor vehicle exhaust (MVE). Many studies have shown associations between air polluti...
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| Veröffentlicht in: | Scientific reports 2017-03, Vol.7 (1), p.45666-45666, Article 45666 |
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| creator | He, Fang Liao, Baoling Pu, Jinding Li, Chenglong Zheng, Mengning Huang, Lingmei Zhou, Yumin Zhao, Dongxing Li, Bing Ran, Pixin |
| description | While the health effects of air pollution have been an international public health concern since at least the 1950s, recent research has focused on two broad sources of air pollution, namely, biomass fuel (BMF) and motor vehicle exhaust (MVE). Many studies have shown associations between air pollution PM and exacerbations of pre-existing COPD, but the role of air pollution PM in the development and progression of COPD is still uncertain. The current study indicates that rats can develop pronounced COPD following chronic exposure to air pollution PM (BMF and MVE), as characterized by lung function reduction, mucus metaplasia, lung and systemic inflammation, emphysema, and small airway remodeling. Comparative analyses demonstrate that both BMF and MVE activate similar pathogenesis that are linked to the development of COPD. These findings also show that some differences are found in the lungs of rats exposed to BMF or MVE, which might result in different phenotypes of COPD. |
| doi_str_mv | 10.1038/srep45666 |
| format | Article |
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These findings also show that some differences are found in the lungs of rats exposed to BMF or MVE, which might result in different phenotypes of COPD.</description><subject>692/308/1426</subject><subject>692/699/1785/4037</subject><subject>82</subject><subject>82/1</subject><subject>82/80</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Air pollution effects</subject><subject>Airborne particulates</subject><subject>Airway Remodeling</subject><subject>Animals</subject><subject>Biomass</subject><subject>Chronic exposure</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Emphysema</subject><subject>Environmental Exposure</subject><subject>Epithelial Cells - pathology</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Inflammation - etiology</subject><subject>Inflammation - metabolism</subject><subject>Lung - 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adverse effects</topic><topic>Air pollution effects</topic><topic>Airborne particulates</topic><topic>Airway Remodeling</topic><topic>Animals</topic><topic>Biomass</topic><topic>Chronic exposure</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Emphysema</topic><topic>Environmental Exposure</topic><topic>Epithelial Cells - pathology</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Inflammation - etiology</topic><topic>Inflammation - metabolism</topic><topic>Lung - pathology</topic><topic>Lung - physiopathology</topic><topic>Lungs</topic><topic>Metaplasia</topic><topic>Motor vehicles</topic><topic>multidisciplinary</topic><topic>Particle Size</topic><topic>Particulate matter</topic><topic>Particulate Matter - adverse effects</topic><topic>Pollution</topic><topic>Public health</topic><topic>Pulmonary Disease, Chronic Obstructive - chemically induced</topic><topic>Pulmonary Disease, Chronic Obstructive - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Fang</au><au>Liao, Baoling</au><au>Pu, Jinding</au><au>Li, Chenglong</au><au>Zheng, Mengning</au><au>Huang, Lingmei</au><au>Zhou, Yumin</au><au>Zhao, Dongxing</au><au>Li, Bing</au><au>Ran, Pixin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to Ambient Particulate Matter Induced COPD in a Rat Model and a Description of the Underlying Mechanism</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-03-31</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>45666</spage><epage>45666</epage><pages>45666-45666</pages><artnum>45666</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>While the health effects of air pollution have been an international public health concern since at least the 1950s, recent research has focused on two broad sources of air pollution, namely, biomass fuel (BMF) and motor vehicle exhaust (MVE). Many studies have shown associations between air pollution PM and exacerbations of pre-existing COPD, but the role of air pollution PM in the development and progression of COPD is still uncertain. The current study indicates that rats can develop pronounced COPD following chronic exposure to air pollution PM (BMF and MVE), as characterized by lung function reduction, mucus metaplasia, lung and systemic inflammation, emphysema, and small airway remodeling. Comparative analyses demonstrate that both BMF and MVE activate similar pathogenesis that are linked to the development of COPD. These findings also show that some differences are found in the lungs of rats exposed to BMF or MVE, which might result in different phenotypes of COPD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28361885</pmid><doi>10.1038/srep45666</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/1426 692/699/1785/4037 82 82/1 82/80 Air pollution Air Pollution - adverse effects Air pollution effects Airborne particulates Airway Remodeling Animals Biomass Chronic exposure Chronic obstructive pulmonary disease Cytokines - metabolism Disease Models, Animal Emphysema Environmental Exposure Epithelial Cells - pathology Female Humanities and Social Sciences Inflammation - etiology Inflammation - metabolism Lung - pathology Lung - physiopathology Lungs Metaplasia Motor vehicles multidisciplinary Particle Size Particulate matter Particulate Matter - adverse effects Pollution Public health Pulmonary Disease, Chronic Obstructive - chemically induced Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Disease, Chronic Obstructive - physiopathology Rats, Sprague-Dawley Respiratory function Respiratory Function Tests Respiratory tract Rodents Science Vehicle emissions |
| title | Exposure to Ambient Particulate Matter Induced COPD in a Rat Model and a Description of the Underlying Mechanism |
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