Genetic redundancy of GATA factors in the extraembryonic trophoblast lineage ensures the progression of preimplantation and postimplantation mammalian development

GATA transcription factors are implicated in establishing cell fate during mammalian development. In early mammalian embryos, GATA3 is selectively expressed in the extraembryonic trophoblast lineage and regulates gene expression to promote trophoblast fate. However, trophoblast-specific GATA3 functi...

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Veröffentlicht in:	Development (Cambridge) 2017-03, Vol.144 (5), p.876-888
Hauptverfasser:	Home, Pratik, Kumar, Ram Parikshan, Ganguly, Avishek, Saha, Biswarup, Milano-Foster, Jessica, Bhattacharya, Bhaswati, Ray, Soma, Gunewardena, Sumedha, Paul, Arindam, Camper, Sally A, Fields, Patrick E, Paul, Soumen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell fate Cell Lineage Clonal deletion Developmental stages Embryo Implantation Embryogenesis Embryonic Development Embryos Female GATA-3 protein GATA2 Transcription Factor - physiology GATA3 Transcription Factor - physiology Gene Deletion Gene expression Humans Lethality Mice Mice, Knockout Placenta - physiology Pregnancy Pregnancy, Animal Ribonucleic acid RNA Sequence Analysis, RNA Stem Cells - cytology Transcription factors Trophoblasts Trophoblasts - cytology Wnt protein
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