MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy
Objectives To study disease mechanisms in multifocal motor neuropathy (MMN) with magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of the median and ulnar nerves. Methods We enrolled ten MMN patients, ten patients with amyotrophic lateral sclerosis (ALS) and ten healthy controls (H...
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| Veröffentlicht in: | European radiology 2017-05, Vol.27 (5), p.2216-2224 |
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| creator | Haakma, Wieke Jongbloed, Bas A. Froeling, Martijn Goedee, H. Stephan Bos, Clemens Leemans, Alexander van den Berg, Leonard H. Hendrikse, Jeroen van der Pol, W. Ludo |
| description | Objectives
To study disease mechanisms in multifocal motor neuropathy (MMN) with magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of the median and ulnar nerves.
Methods
We enrolled ten MMN patients, ten patients with amyotrophic lateral sclerosis (ALS) and ten healthy controls (HCs). Patients underwent MRI (in a prone position) and nerve conduction studies. DTI and fat-suppressed T2-weighted scans of the forearms were performed on a 3.0T MRI scanner. Fibre tractography of the median and ulnar nerves was performed to extract diffusion parameters: fractional anisotropy (FA), mean (MD), axial (AD) and radial (RD) diffusivity. Cross-sectional areas (CSA) were measured on T2-weighted scans.
Results
Forty-five out of 60 arms were included in the analysis. AD was significantly lower in MMN patients (2.20 ± 0.12 × 10
-3
mm
2
/s) compared to ALS patients (2.31 ± 0.17 × 10
-3
mm
2
/s;
p
|
| doi_str_mv | 10.1007/s00330-016-4575-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5374174</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1891869998</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-5c5eca923e8c5c29362531157ab4920f29094685e73ed0a218d180296d6dccab3</originalsourceid><addsrcrecordid>eNqNkU1rFTEUhoMo9lr9AW4k4MbN6MnXJNkIUvwoVAqlrkNuJnMndSa5JjOV_nszvbVUQXB1Fu9z3vPxIvSSwFsCIN8VAMagAdI2XEjRwCO0IZzRhoDij9EGNFON1JofoWelXAGAJlw-RUdUtkIwYBs0fL04xWVIPwueh-C--xjiDtvYYTvOPvsOd6HvlxJSxCFWxuPJd8HGW2YZo804-nztyypPyziHPjk74inNaZWWnPZ2Hm6eoye9HYt_cVeP0bdPHy9PvjRn559PTz6cNU4AmxvhhHdWU-aVE45q1lLBCBHSbrmm0FMNmrdKeMl8B5YS1REFVLdd2zlnt-wYvT_47pdt3dT5OGc7mn0Ok803Jtlg_lRiGMwuXRvBJCeSV4M3dwY5_Vh8mc0UivPjaKNPSzFEaaJarbX6D1RoSeoFpKKv_0Kv0pJj_USlFGVCCVgNyYFyOZWSfX-_NwGzRm4OkZsauVkjN1B7Xj08-L7jd8YVoAegVCnufH4w-p-uvwBjuLci</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1882358508</pqid></control><display><type>article</type><title>MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Haakma, Wieke ; Jongbloed, Bas A. ; Froeling, Martijn ; Goedee, H. Stephan ; Bos, Clemens ; Leemans, Alexander ; van den Berg, Leonard H. ; Hendrikse, Jeroen ; van der Pol, W. Ludo</creator><creatorcontrib>Haakma, Wieke ; Jongbloed, Bas A. ; Froeling, Martijn ; Goedee, H. Stephan ; Bos, Clemens ; Leemans, Alexander ; van den Berg, Leonard H. ; Hendrikse, Jeroen ; van der Pol, W. Ludo</creatorcontrib><description>Objectives
To study disease mechanisms in multifocal motor neuropathy (MMN) with magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of the median and ulnar nerves.
Methods
We enrolled ten MMN patients, ten patients with amyotrophic lateral sclerosis (ALS) and ten healthy controls (HCs). Patients underwent MRI (in a prone position) and nerve conduction studies. DTI and fat-suppressed T2-weighted scans of the forearms were performed on a 3.0T MRI scanner. Fibre tractography of the median and ulnar nerves was performed to extract diffusion parameters: fractional anisotropy (FA), mean (MD), axial (AD) and radial (RD) diffusivity. Cross-sectional areas (CSA) were measured on T2-weighted scans.
Results
Forty-five out of 60 arms were included in the analysis. AD was significantly lower in MMN patients (2.20 ± 0.12 × 10
-3
mm
2
/s) compared to ALS patients (2.31 ± 0.17 × 10
-3
mm
2
/s;
p
< 0.05) and HCs (2.31± 0.17 × 10
-3
mm
2
/s;
p
< 0.05). Segmental analysis showed significant restriction of AD, RD and MD (
p
< 0.005) in the proximal third of the nerves. CSA was significantly larger in MMN patients compared to ALS patients and HCs (
p
< 0.01).
Conclusions
Thickening of nerves is compatible with changes in the myelin sheath structure, whereas lowered AD values suggest axonal dysfunction. These findings suggest that myelin and axons are diffusely involved in MMN pathogenesis.
Key Points
•
Diffusion magnetic resonance imaging provides quantitative information about multifocal motor neuropathy (MMN).
•
Diffusion tensor imaging allows non-invasive evaluation of the forearm nerves in MMN.
•
Nerve thickening and lowered diffusion parameters suggests myelin and axonal changes.
•
This study can help to provide insight into pathological mechanisms of MMN.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-016-4575-0</identifier><identifier>PMID: 27655303</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - diagnostic imaging ; Amyotrophic Lateral Sclerosis - physiopathology ; Anisotropy ; Case-Control Studies ; Diagnostic Radiology ; Diffusion Magnetic Resonance Imaging - methods ; Diffusion Tensor Imaging - methods ; Female ; Forearm - innervation ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Median Nerve - diagnostic imaging ; Median Nerve - physiopathology ; Medicine ; Medicine & Public Health ; Middle Aged ; Motor Neuron Disease - diagnostic imaging ; Motor Neuron Disease - physiopathology ; Nervous system ; Neural Conduction - physiology ; Neuro ; Neuroradiology ; Pathogenesis ; Radiology ; Ulnar Nerve - diagnostic imaging ; Ulnar Nerve - physiopathology ; Ultrasound</subject><ispartof>European radiology, 2017-05, Vol.27 (5), p.2216-2224</ispartof><rights>The Author(s) 2016</rights><rights>European Radiology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-5c5eca923e8c5c29362531157ab4920f29094685e73ed0a218d180296d6dccab3</citedby><cites>FETCH-LOGICAL-c503t-5c5eca923e8c5c29362531157ab4920f29094685e73ed0a218d180296d6dccab3</cites><orcidid>0000-0003-1586-885X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-016-4575-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-016-4575-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27655303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haakma, Wieke</creatorcontrib><creatorcontrib>Jongbloed, Bas A.</creatorcontrib><creatorcontrib>Froeling, Martijn</creatorcontrib><creatorcontrib>Goedee, H. Stephan</creatorcontrib><creatorcontrib>Bos, Clemens</creatorcontrib><creatorcontrib>Leemans, Alexander</creatorcontrib><creatorcontrib>van den Berg, Leonard H.</creatorcontrib><creatorcontrib>Hendrikse, Jeroen</creatorcontrib><creatorcontrib>van der Pol, W. Ludo</creatorcontrib><title>MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To study disease mechanisms in multifocal motor neuropathy (MMN) with magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of the median and ulnar nerves.
Methods
We enrolled ten MMN patients, ten patients with amyotrophic lateral sclerosis (ALS) and ten healthy controls (HCs). Patients underwent MRI (in a prone position) and nerve conduction studies. DTI and fat-suppressed T2-weighted scans of the forearms were performed on a 3.0T MRI scanner. Fibre tractography of the median and ulnar nerves was performed to extract diffusion parameters: fractional anisotropy (FA), mean (MD), axial (AD) and radial (RD) diffusivity. Cross-sectional areas (CSA) were measured on T2-weighted scans.
Results
Forty-five out of 60 arms were included in the analysis. AD was significantly lower in MMN patients (2.20 ± 0.12 × 10
-3
mm
2
/s) compared to ALS patients (2.31 ± 0.17 × 10
-3
mm
2
/s;
p
< 0.05) and HCs (2.31± 0.17 × 10
-3
mm
2
/s;
p
< 0.05). Segmental analysis showed significant restriction of AD, RD and MD (
p
< 0.005) in the proximal third of the nerves. CSA was significantly larger in MMN patients compared to ALS patients and HCs (
p
< 0.01).
Conclusions
Thickening of nerves is compatible with changes in the myelin sheath structure, whereas lowered AD values suggest axonal dysfunction. These findings suggest that myelin and axons are diffusely involved in MMN pathogenesis.
Key Points
•
Diffusion magnetic resonance imaging provides quantitative information about multifocal motor neuropathy (MMN).
•
Diffusion tensor imaging allows non-invasive evaluation of the forearm nerves in MMN.
•
Nerve thickening and lowered diffusion parameters suggests myelin and axonal changes.
•
This study can help to provide insight into pathological mechanisms of MMN.</description><subject>Adult</subject><subject>Aged</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - diagnostic imaging</subject><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Anisotropy</subject><subject>Case-Control Studies</subject><subject>Diagnostic Radiology</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Diffusion Tensor Imaging - methods</subject><subject>Female</subject><subject>Forearm - innervation</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Median Nerve - diagnostic imaging</subject><subject>Median Nerve - physiopathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Motor Neuron Disease - diagnostic imaging</subject><subject>Motor Neuron Disease - physiopathology</subject><subject>Nervous system</subject><subject>Neural Conduction - physiology</subject><subject>Neuro</subject><subject>Neuroradiology</subject><subject>Pathogenesis</subject><subject>Radiology</subject><subject>Ulnar Nerve - diagnostic imaging</subject><subject>Ulnar Nerve - physiopathology</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1rFTEUhoMo9lr9AW4k4MbN6MnXJNkIUvwoVAqlrkNuJnMndSa5JjOV_nszvbVUQXB1Fu9z3vPxIvSSwFsCIN8VAMagAdI2XEjRwCO0IZzRhoDij9EGNFON1JofoWelXAGAJlw-RUdUtkIwYBs0fL04xWVIPwueh-C--xjiDtvYYTvOPvsOd6HvlxJSxCFWxuPJd8HGW2YZo804-nztyypPyziHPjk74inNaZWWnPZ2Hm6eoye9HYt_cVeP0bdPHy9PvjRn559PTz6cNU4AmxvhhHdWU-aVE45q1lLBCBHSbrmm0FMNmrdKeMl8B5YS1REFVLdd2zlnt-wYvT_47pdt3dT5OGc7mn0Ok803Jtlg_lRiGMwuXRvBJCeSV4M3dwY5_Vh8mc0UivPjaKNPSzFEaaJarbX6D1RoSeoFpKKv_0Kv0pJj_USlFGVCCVgNyYFyOZWSfX-_NwGzRm4OkZsauVkjN1B7Xj08-L7jd8YVoAegVCnufH4w-p-uvwBjuLci</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Haakma, Wieke</creator><creator>Jongbloed, Bas A.</creator><creator>Froeling, Martijn</creator><creator>Goedee, H. Stephan</creator><creator>Bos, Clemens</creator><creator>Leemans, Alexander</creator><creator>van den Berg, Leonard H.</creator><creator>Hendrikse, Jeroen</creator><creator>van der Pol, W. Ludo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1586-885X</orcidid></search><sort><creationdate>20170501</creationdate><title>MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy</title><author>Haakma, Wieke ; Jongbloed, Bas A. ; Froeling, Martijn ; Goedee, H. Stephan ; Bos, Clemens ; Leemans, Alexander ; van den Berg, Leonard H. ; Hendrikse, Jeroen ; van der Pol, W. Ludo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-5c5eca923e8c5c29362531157ab4920f29094685e73ed0a218d180296d6dccab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - diagnostic imaging</topic><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Anisotropy</topic><topic>Case-Control Studies</topic><topic>Diagnostic Radiology</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Diffusion Tensor Imaging - methods</topic><topic>Female</topic><topic>Forearm - innervation</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Median Nerve - diagnostic imaging</topic><topic>Median Nerve - physiopathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Motor Neuron Disease - diagnostic imaging</topic><topic>Motor Neuron Disease - physiopathology</topic><topic>Nervous system</topic><topic>Neural Conduction - physiology</topic><topic>Neuro</topic><topic>Neuroradiology</topic><topic>Pathogenesis</topic><topic>Radiology</topic><topic>Ulnar Nerve - diagnostic imaging</topic><topic>Ulnar Nerve - physiopathology</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haakma, Wieke</creatorcontrib><creatorcontrib>Jongbloed, Bas A.</creatorcontrib><creatorcontrib>Froeling, Martijn</creatorcontrib><creatorcontrib>Goedee, H. Stephan</creatorcontrib><creatorcontrib>Bos, Clemens</creatorcontrib><creatorcontrib>Leemans, Alexander</creatorcontrib><creatorcontrib>van den Berg, Leonard H.</creatorcontrib><creatorcontrib>Hendrikse, Jeroen</creatorcontrib><creatorcontrib>van der Pol, W. Ludo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haakma, Wieke</au><au>Jongbloed, Bas A.</au><au>Froeling, Martijn</au><au>Goedee, H. Stephan</au><au>Bos, Clemens</au><au>Leemans, Alexander</au><au>van den Berg, Leonard H.</au><au>Hendrikse, Jeroen</au><au>van der Pol, W. Ludo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>27</volume><issue>5</issue><spage>2216</spage><epage>2224</epage><pages>2216-2224</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To study disease mechanisms in multifocal motor neuropathy (MMN) with magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of the median and ulnar nerves.
Methods
We enrolled ten MMN patients, ten patients with amyotrophic lateral sclerosis (ALS) and ten healthy controls (HCs). Patients underwent MRI (in a prone position) and nerve conduction studies. DTI and fat-suppressed T2-weighted scans of the forearms were performed on a 3.0T MRI scanner. Fibre tractography of the median and ulnar nerves was performed to extract diffusion parameters: fractional anisotropy (FA), mean (MD), axial (AD) and radial (RD) diffusivity. Cross-sectional areas (CSA) were measured on T2-weighted scans.
Results
Forty-five out of 60 arms were included in the analysis. AD was significantly lower in MMN patients (2.20 ± 0.12 × 10
-3
mm
2
/s) compared to ALS patients (2.31 ± 0.17 × 10
-3
mm
2
/s;
p
< 0.05) and HCs (2.31± 0.17 × 10
-3
mm
2
/s;
p
< 0.05). Segmental analysis showed significant restriction of AD, RD and MD (
p
< 0.005) in the proximal third of the nerves. CSA was significantly larger in MMN patients compared to ALS patients and HCs (
p
< 0.01).
Conclusions
Thickening of nerves is compatible with changes in the myelin sheath structure, whereas lowered AD values suggest axonal dysfunction. These findings suggest that myelin and axons are diffusely involved in MMN pathogenesis.
Key Points
•
Diffusion magnetic resonance imaging provides quantitative information about multifocal motor neuropathy (MMN).
•
Diffusion tensor imaging allows non-invasive evaluation of the forearm nerves in MMN.
•
Nerve thickening and lowered diffusion parameters suggests myelin and axonal changes.
•
This study can help to provide insight into pathological mechanisms of MMN.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27655303</pmid><doi>10.1007/s00330-016-4575-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1586-885X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2017-05, Vol.27 (5), p.2216-2224 |
| issn | 0938-7994 1432-1084 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - diagnostic imaging Amyotrophic Lateral Sclerosis - physiopathology Anisotropy Case-Control Studies Diagnostic Radiology Diffusion Magnetic Resonance Imaging - methods Diffusion Tensor Imaging - methods Female Forearm - innervation Humans Imaging Internal Medicine Interventional Radiology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Median Nerve - diagnostic imaging Median Nerve - physiopathology Medicine Medicine & Public Health Middle Aged Motor Neuron Disease - diagnostic imaging Motor Neuron Disease - physiopathology Nervous system Neural Conduction - physiology Neuro Neuroradiology Pathogenesis Radiology Ulnar Nerve - diagnostic imaging Ulnar Nerve - physiopathology Ultrasound |
| title | MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy |
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