Lin28 induces resistance to anti-androgens via promotion of AR splice variant generation

BACKGROUND Prostate cancer (PCa) is androgen‐dependent initially and progresses to a castration‐resistant state after androgen deprivation therapy. Treatment options for castration‐resistant PCa include the potent second‐generation anti‐androgen enzalutamide or CYP17A1 inhibitor abiraterone. Recent...

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Veröffentlicht in:	The Prostate 2016-04, Vol.76 (5), p.445-455
Hauptverfasser:	Tummala, Ramakumar, Nadiminty, Nagalakshmi, Lou, Wei, Evans, Christopher P., Gao, Allen C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Androgen Antagonists - pharmacology Androgen Antagonists - therapeutic use anti-androgens AR variants Cell Line, Tumor Disease Progression Drug Resistance, Neoplasm - genetics Humans Lin28 Male Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - metabolism Protein Isoforms - metabolism Receptors, Androgen - metabolism resistance RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism
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