Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein

Misfolding and aggregation of alpha-synuclein (αsyn) resulting in cytotoxicity is a hallmark of Parkinson's disease (PD) and related synucleinopathies. The recent body of evidence indicates that αsyn can be released from neuronal cells by nonconventional exocytosis involving extracellular vesic...

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Veröffentlicht in:	Frontiers in neuroscience 2017-03, Vol.11, p.172-172
Hauptverfasser:	Delenclos, Marion, Trendafilova, Teodora, Mahesh, Divya, Baine, Ann M, Moussaud, Simon, Yan, Irene K, Patel, Tushar, McLean, Pamela J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Caveolin Cell culture Clathrin Complementation Cytotoxicity Exocytosis Exosomes Heparin Internalization Movement disorders Neurodegeneration Neurodegenerative diseases Neuroscience Parkinson's disease Pathogenesis Proteins Proteoglycans Sulfates Synuclein
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