Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence
The dopamine transporter (DAT) plays a crucial role in the pathogenesis of alcohol dependence (AD) and major depression (MD), and males have more risk factors for the development of AD. However, imaging studies on brain DAT availability in males with AD comorbid with MD (AD/MD) are limited, and the...
Gespeichert in:
| Veröffentlicht in: | Medicine (Baltimore) 2016-08, Vol.95 (33), p.e4048-e4048 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e4048 |
|---|---|
| container_issue | 33 |
| container_start_page | e4048 |
| container_title | Medicine (Baltimore) |
| container_volume | 95 |
| creator | Yen, Che-Hung Shih, Mei-Chen Cheng, Cheng-Yi Ma, Kuo-Hsing Lu, Ru-Band Huang, San-Yuan |
| description | The dopamine transporter (DAT) plays a crucial role in the pathogenesis of alcohol dependence (AD) and major depression (MD), and males have more risk factors for the development of AD. However, imaging studies on brain DAT availability in males with AD comorbid with MD (AD/MD) are limited, and the association of DAT availability with cognitive function and depressive scores in patients with AD/MD has not been analyzed. Hence, this study examined the relationship between brain DAT availability, cognitive function, and depressive symptoms in different subgroups of males with AD.Single-photon emission computed tomography imaging with Tc-TRODAT-1 as a ligand was used to measure striatal DAT availability in 49 patients with AD (28 pure AD and 21 AD/MD) and 24 age- and sex-matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and 17-item Hamilton Depression Rating Scale were used to assess neurocognitive function and depressive scores, respectively. Patients with AD showed a significant reduction of DAT availability in 3 brain regions (P |
| doi_str_mv | 10.1097/MD.0000000000004048 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5370777</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>27537550</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4502-fe64e22787348297f45e69300bff17d8e83a3f22e72a687b1cd861dea313b2333</originalsourceid><addsrcrecordid>eNpdkNtKxDAQhoMouh6eQJC-QDXHpr0RxDMo3uh1SJvJbjSblKRVfHu7rooaGAKZ-f4JH0KHBB8T3MiT-4tj_OtwzOsNNCOCVaVoKr6JZhhTUcpG8h20m_MzxoRJyrfRDpWCSSHwDM1vQxfDPI0QhiKBGbvBxVBEW5jY66ULUAxJh9zHNEAq9Kt2XrfOu-G9cKEwzlpIKzaP7TzFsc8rVvsuLqIvDPQQDIQO9tGW1T7Dwde9h56uLh_Pb8q7h-vb87O7suMC09JCxYFSWUvGa9pIywVUDcO4tZZIU0PNNLOUgqS6qmVLOlNXxIBmhLWUMbaHTte5_dguwXTT15L2qk9uqdO7itqpv53gFmoeX9UkBEsppwC2DuhSzDmB_WEJVivv6v5C_fc-UUe_1_4w36KnAb4eeIt-Eplf_PgGSS1A-2HxmSdkQ0uKSYXrqcrVE2UfP2OQsg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence</title><source>Wolters Kluwer Open Health</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>IngentaConnect Free/Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Yen, Che-Hung ; Shih, Mei-Chen ; Cheng, Cheng-Yi ; Ma, Kuo-Hsing ; Lu, Ru-Band ; Huang, San-Yuan</creator><creatorcontrib>Yen, Che-Hung ; Shih, Mei-Chen ; Cheng, Cheng-Yi ; Ma, Kuo-Hsing ; Lu, Ru-Band ; Huang, San-Yuan</creatorcontrib><description>The dopamine transporter (DAT) plays a crucial role in the pathogenesis of alcohol dependence (AD) and major depression (MD), and males have more risk factors for the development of AD. However, imaging studies on brain DAT availability in males with AD comorbid with MD (AD/MD) are limited, and the association of DAT availability with cognitive function and depressive scores in patients with AD/MD has not been analyzed. Hence, this study examined the relationship between brain DAT availability, cognitive function, and depressive symptoms in different subgroups of males with AD.Single-photon emission computed tomography imaging with Tc-TRODAT-1 as a ligand was used to measure striatal DAT availability in 49 patients with AD (28 pure AD and 21 AD/MD) and 24 age- and sex-matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and 17-item Hamilton Depression Rating Scale were used to assess neurocognitive function and depressive scores, respectively. Patients with AD showed a significant reduction of DAT availability in 3 brain regions (P < 0.001), and this reduction was more pronounced in the patients with pure AD compared to healthy controls. The patients with AD showed significantly poorer performance on the WCST, but only in the control group was DAT availability significantly negatively correlated with total errors and perseverative errors (P < 0.001).These preliminary findings suggest that DAT availability is associated with neurocognitive function, and incongruent reduction of DAT may play a pathophysiological role in different subgroups of AD. In addition, decreased DAT availability may be associated with the severity of depressive symptoms in patients with AD/MD.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000004048</identifier><identifier>PMID: 27537550</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Alcoholism - diagnostic imaging ; Alcoholism - metabolism ; Alcoholism - psychology ; Brain - diagnostic imaging ; Brain - metabolism ; Case-Control Studies ; Cognition ; Depression - metabolism ; Dopamine Plasma Membrane Transport Proteins - metabolism ; Humans ; Male ; Neuropsychological Tests ; Observational Study ; Psychiatric Status Rating Scales ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Medicine (Baltimore), 2016-08, Vol.95 (33), p.e4048-e4048</ispartof><rights>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4502-fe64e22787348297f45e69300bff17d8e83a3f22e72a687b1cd861dea313b2333</citedby><cites>FETCH-LOGICAL-c4502-fe64e22787348297f45e69300bff17d8e83a3f22e72a687b1cd861dea313b2333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370777/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370777/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27537550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yen, Che-Hung</creatorcontrib><creatorcontrib>Shih, Mei-Chen</creatorcontrib><creatorcontrib>Cheng, Cheng-Yi</creatorcontrib><creatorcontrib>Ma, Kuo-Hsing</creatorcontrib><creatorcontrib>Lu, Ru-Band</creatorcontrib><creatorcontrib>Huang, San-Yuan</creatorcontrib><title>Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The dopamine transporter (DAT) plays a crucial role in the pathogenesis of alcohol dependence (AD) and major depression (MD), and males have more risk factors for the development of AD. However, imaging studies on brain DAT availability in males with AD comorbid with MD (AD/MD) are limited, and the association of DAT availability with cognitive function and depressive scores in patients with AD/MD has not been analyzed. Hence, this study examined the relationship between brain DAT availability, cognitive function, and depressive symptoms in different subgroups of males with AD.Single-photon emission computed tomography imaging with Tc-TRODAT-1 as a ligand was used to measure striatal DAT availability in 49 patients with AD (28 pure AD and 21 AD/MD) and 24 age- and sex-matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and 17-item Hamilton Depression Rating Scale were used to assess neurocognitive function and depressive scores, respectively. Patients with AD showed a significant reduction of DAT availability in 3 brain regions (P < 0.001), and this reduction was more pronounced in the patients with pure AD compared to healthy controls. The patients with AD showed significantly poorer performance on the WCST, but only in the control group was DAT availability significantly negatively correlated with total errors and perseverative errors (P < 0.001).These preliminary findings suggest that DAT availability is associated with neurocognitive function, and incongruent reduction of DAT may play a pathophysiological role in different subgroups of AD. In addition, decreased DAT availability may be associated with the severity of depressive symptoms in patients with AD/MD.</description><subject>Adult</subject><subject>Alcoholism - diagnostic imaging</subject><subject>Alcoholism - metabolism</subject><subject>Alcoholism - psychology</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Case-Control Studies</subject><subject>Cognition</subject><subject>Depression - metabolism</subject><subject>Dopamine Plasma Membrane Transport Proteins - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Neuropsychological Tests</subject><subject>Observational Study</subject><subject>Psychiatric Status Rating Scales</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkNtKxDAQhoMouh6eQJC-QDXHpr0RxDMo3uh1SJvJbjSblKRVfHu7rooaGAKZ-f4JH0KHBB8T3MiT-4tj_OtwzOsNNCOCVaVoKr6JZhhTUcpG8h20m_MzxoRJyrfRDpWCSSHwDM1vQxfDPI0QhiKBGbvBxVBEW5jY66ULUAxJh9zHNEAq9Kt2XrfOu-G9cKEwzlpIKzaP7TzFsc8rVvsuLqIvDPQQDIQO9tGW1T7Dwde9h56uLh_Pb8q7h-vb87O7suMC09JCxYFSWUvGa9pIywVUDcO4tZZIU0PNNLOUgqS6qmVLOlNXxIBmhLWUMbaHTte5_dguwXTT15L2qk9uqdO7itqpv53gFmoeX9UkBEsppwC2DuhSzDmB_WEJVivv6v5C_fc-UUe_1_4w36KnAb4eeIt-Eplf_PgGSS1A-2HxmSdkQ0uKSYXrqcrVE2UfP2OQsg</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Yen, Che-Hung</creator><creator>Shih, Mei-Chen</creator><creator>Cheng, Cheng-Yi</creator><creator>Ma, Kuo-Hsing</creator><creator>Lu, Ru-Band</creator><creator>Huang, San-Yuan</creator><general>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20160801</creationdate><title>Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence</title><author>Yen, Che-Hung ; Shih, Mei-Chen ; Cheng, Cheng-Yi ; Ma, Kuo-Hsing ; Lu, Ru-Band ; Huang, San-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4502-fe64e22787348297f45e69300bff17d8e83a3f22e72a687b1cd861dea313b2333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Alcoholism - diagnostic imaging</topic><topic>Alcoholism - metabolism</topic><topic>Alcoholism - psychology</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Case-Control Studies</topic><topic>Cognition</topic><topic>Depression - metabolism</topic><topic>Dopamine Plasma Membrane Transport Proteins - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Neuropsychological Tests</topic><topic>Observational Study</topic><topic>Psychiatric Status Rating Scales</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yen, Che-Hung</creatorcontrib><creatorcontrib>Shih, Mei-Chen</creatorcontrib><creatorcontrib>Cheng, Cheng-Yi</creatorcontrib><creatorcontrib>Ma, Kuo-Hsing</creatorcontrib><creatorcontrib>Lu, Ru-Band</creatorcontrib><creatorcontrib>Huang, San-Yuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yen, Che-Hung</au><au>Shih, Mei-Chen</au><au>Cheng, Cheng-Yi</au><au>Ma, Kuo-Hsing</au><au>Lu, Ru-Band</au><au>Huang, San-Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>95</volume><issue>33</issue><spage>e4048</spage><epage>e4048</epage><pages>e4048-e4048</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The dopamine transporter (DAT) plays a crucial role in the pathogenesis of alcohol dependence (AD) and major depression (MD), and males have more risk factors for the development of AD. However, imaging studies on brain DAT availability in males with AD comorbid with MD (AD/MD) are limited, and the association of DAT availability with cognitive function and depressive scores in patients with AD/MD has not been analyzed. Hence, this study examined the relationship between brain DAT availability, cognitive function, and depressive symptoms in different subgroups of males with AD.Single-photon emission computed tomography imaging with Tc-TRODAT-1 as a ligand was used to measure striatal DAT availability in 49 patients with AD (28 pure AD and 21 AD/MD) and 24 age- and sex-matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and 17-item Hamilton Depression Rating Scale were used to assess neurocognitive function and depressive scores, respectively. Patients with AD showed a significant reduction of DAT availability in 3 brain regions (P < 0.001), and this reduction was more pronounced in the patients with pure AD compared to healthy controls. The patients with AD showed significantly poorer performance on the WCST, but only in the control group was DAT availability significantly negatively correlated with total errors and perseverative errors (P < 0.001).These preliminary findings suggest that DAT availability is associated with neurocognitive function, and incongruent reduction of DAT may play a pathophysiological role in different subgroups of AD. In addition, decreased DAT availability may be associated with the severity of depressive symptoms in patients with AD/MD.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>27537550</pmid><doi>10.1097/MD.0000000000004048</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0025-7974 |
| ispartof | Medicine (Baltimore), 2016-08, Vol.95 (33), p.e4048-e4048 |
| issn | 0025-7974 1536-5964 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5370777 |
| source | Wolters Kluwer Open Health; MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Free/Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Alcoholism - diagnostic imaging Alcoholism - metabolism Alcoholism - psychology Brain - diagnostic imaging Brain - metabolism Case-Control Studies Cognition Depression - metabolism Dopamine Plasma Membrane Transport Proteins - metabolism Humans Male Neuropsychological Tests Observational Study Psychiatric Status Rating Scales Tomography, Emission-Computed, Single-Photon |
| title | Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T05%3A54%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Incongruent%20reduction%20of%20dopamine%20transporter%20availability%20in%20different%20subgroups%20of%20alcohol%20dependence&rft.jtitle=Medicine%20(Baltimore)&rft.au=Yen,%20Che-Hung&rft.date=2016-08-01&rft.volume=95&rft.issue=33&rft.spage=e4048&rft.epage=e4048&rft.pages=e4048-e4048&rft.issn=0025-7974&rft.eissn=1536-5964&rft_id=info:doi/10.1097/MD.0000000000004048&rft_dat=%3Cpubmed_cross%3E27537550%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/27537550&rfr_iscdi=true |