The challenges of tumor genetic diversity

The authors review and discuss the implications of genomic analyses documenting the diversity of tumors, both among patients and within individual tumors. Genetic diversity among solid tumors limits targeted therapies, because few mutations that drive tumors are both targetable and at high prevalenc...

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Veröffentlicht in:	Cancer 2017-03, Vol.123 (6), p.917-927
Hauptverfasser:	Mroz, Edmund A., Rocco, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor Cancer Clonal Evolution driver mutations Gene sequencing Genetic diversity Genetic Heterogeneity Genetic Predisposition to Disease Genetic Variation Genomic analysis Heterogeneity Humans immunotherapy intratumor heterogeneity Molecular Targeted Therapy Mutation Neoplasms - genetics Neoplasms - mortality Neoplasms - pathology Neoplasms - therapy next‐generation sequencing Oncology Panels Patients Precision Medicine Prognosis Solid tumors targeted therapy Therapy Tumors
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