Emphysema induced by elastase enhances acute inflammatory pulmonary response to intraperitoneal LPS in rats

Summary Abnormalities in lungs caused by emphysema might alter their response to sepsis and the occurrence of acute lung injury (ALI). This study compared the extension of ALI in response to intraperitoneal lipopolysaccharide (LPS) injection in Wistar rats with and without emphysema induced by elast...

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Veröffentlicht in:	International journal of experimental pathology 2016-12, Vol.97 (6), p.430-437
Hauptverfasser:	Fonseca, Lídia Maria Carneiro, Reboredo, Maycon Moura, Lucinda, Leda Marília Fonseca, Fazza, Thaís Fernanda, Rabelo, Maria Aparecida Esteves, Fonseca, Adenilson Souza, Paoli, Flavia, Pinheiro, Bruno Valle
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lung injury Acute Lung Injury - chemically induced Acute Lung Injury - metabolism Acute Lung Injury - pathology acute respiratory distress syndrome Animals Bronchoalveolar Lavage Fluid Chemokine CXCL2 - genetics Chemokine CXCL2 - metabolism Disease Models, Animal Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology Injections, Intraperitoneal Interleukin-6 - genetics Interleukin-6 - metabolism lipopolysaccharides Lipopolysaccharides - adverse effects Lung - metabolism Lung - pathology Male Original pancreatic elastase Pancreatic Elastase - adverse effects pulmonary emphysema Pulmonary Emphysema - chemically induced Pulmonary Emphysema - metabolism Pulmonary Emphysema - pathology Rats Rats, Wistar Respiratory Distress Syndrome, Adult - chemically induced Respiratory Distress Syndrome, Adult - metabolism Respiratory Distress Syndrome, Adult - pathology sepsis Sepsis - chemically induced Sepsis - metabolism Sepsis - pathology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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