It’s All in the Delivery: Improving AAV Transfection Efficiency with Exosomes

Conversely, exo-AAVs might be useful for expressing genes to address dysfunction in supporting cells, as previously shown.9 Thus, accomplishing specific delivery to a sub-compartment of the inner ear (cochlea versus vestibular) or expression within a particular cell type is an important next step to...

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Veröffentlicht in:	Molecular therapy 2017-02, Vol.25 (2), p.309-311
Hauptverfasser:	Martin, Donna M., Raphael, Yehoash
Format:	Artikel
Sprache:	eng
Schlagworte:	Cochlea Data processing Deafness Dependovirus - genetics Ear diseases Ears & hearing Efficiency Exosomes Gene expression Gene therapy Genetic engineering Hearing loss Humans Inner ear Mutation Neonates Proteins Regulatory sequences Transfection Vectors (Biology) Vestibular system Viral infections
Online-Zugang:	Volltext
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