Normal radial migration and lamination are maintained in dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout mice

Developmental dyslexia is a common disorder with a strong genetic component, but the underlying molecular mechanisms are still unknown. Several candidate dyslexia-susceptibility genes, including KIAA0319 , DYX1C1, and DCDC2 , have been identified in humans. RNA interference experiments targeting the...

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Veröffentlicht in:	Brain Structure and Function 2017-04, Vol.222 (3), p.1367-1384
Hauptverfasser:	Martinez-Garay, Isabel, Guidi, Luiz G., Holloway, Zoe G., Bailey, Melissa A. G., Lyngholm, Daniel, Schneider, Tomasz, Donnison, Timothy, Butt, Simon J. B., Monaco, Anthony P., Molnár, Zoltán, Velayos-Baeza, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Anatomy & physiology Animal cognition Animals Animals, Newborn Anxiety - etiology Anxiety - genetics Biomedical and Life Sciences Biomedicine Brain - metabolism Cell Biology Cell Movement - genetics Dark Adaptation - genetics Disease Models, Animal Dyslexia Dyslexia - complications Dyslexia - genetics Dyslexia - pathology Electroporation Embryo, Mammalian Female Gene Expression Regulation, Developmental - genetics Genotype In Vitro Techniques Ki-67 Antigen - metabolism Luminescent Proteins - genetics Luminescent Proteins - metabolism Male Membrane Potentials - genetics Mice Mice, Inbred C57BL Mice, Knockout Neocortex - metabolism Neocortex - pathology Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurogenesis - genetics Neurology Neurons Neurons - physiology Neurosciences Original Original Article Patch-Clamp Techniques PAX6 Transcription Factor - metabolism Pregnancy Prepulse Inhibition - genetics Repressor Proteins - genetics Repressor Proteins - metabolism RNA Interference Rodents Sensory Gating - genetics T-Box Domain Proteins - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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