Methylation on RNA: A Potential Mechanism Related to Immune Priming within But Not across Generations
Invertebrate immune priming is a growing field in immunology. This phenomenon refers to the ability of invertebrates to generate a more vigorous immune response to a second encounter with a specific pathogen and can occur within and across generations. Although the precise mechanism has not been elu...
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| Veröffentlicht in: | Frontiers in microbiology 2017-03, Vol.8, p.473-473 |
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| creator | Castro-Vargas, Cynthia Linares-López, César López-Torres, Adolfo Wrobel, Katarzyna Torres-Guzmán, Juan C Hernández, Gloria A G Wrobel, Kazimierz Lanz-Mendoza, Humberto Contreras-Garduño, Jorge |
| description | Invertebrate immune priming is a growing field in immunology. This phenomenon refers to the ability of invertebrates to generate a more vigorous immune response to a second encounter with a specific pathogen and can occur within and across generations. Although the precise mechanism has not been elucidated, it has been suggested that methylation of DNA is a cornerstone for this phenomenon. Here, using a novel method of analytical chemistry (a reversed-phase liquid chromatography procedure) and the beetle
as a model system, we did not find evidence to support this hypothesis taking into account the percentage of methylated cytosine entities in DNA (5mdC) within or across generations. However, we found a lower percentage of methylated cytosine entities in RNA (5mC) within but not across generations in immune priming experiments with adults against the bacteria
and larvae against the fungus
. To our knowledge, this is the first report suggesting a role of differential methylation on RNA during immune priming within generations. |
| doi_str_mv | 10.3389/fmicb.2017.00473 |
| format | Article |
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as a model system, we did not find evidence to support this hypothesis taking into account the percentage of methylated cytosine entities in DNA (5mdC) within or across generations. However, we found a lower percentage of methylated cytosine entities in RNA (5mC) within but not across generations in immune priming experiments with adults against the bacteria
and larvae against the fungus
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as a model system, we did not find evidence to support this hypothesis taking into account the percentage of methylated cytosine entities in DNA (5mdC) within or across generations. However, we found a lower percentage of methylated cytosine entities in RNA (5mC) within but not across generations in immune priming experiments with adults against the bacteria
and larvae against the fungus
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as a model system, we did not find evidence to support this hypothesis taking into account the percentage of methylated cytosine entities in DNA (5mdC) within or across generations. However, we found a lower percentage of methylated cytosine entities in RNA (5mC) within but not across generations in immune priming experiments with adults against the bacteria
and larvae against the fungus
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| subjects | Microbiology |
| title | Methylation on RNA: A Potential Mechanism Related to Immune Priming within But Not across Generations |
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