Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina

(-)-epigallocatechin-3-gallate (EGCG), a major catechin component of green tea, is reported to delay or prevent certain forms of cancer, arthritis, cardiovascular disease, and neurodegenerative disorders. In this study, we determined if systemically administered EGCG could protect the retina against...

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Veröffentlicht in:	Molecular vision 2017-03, Vol.23, p.171-178
Hauptverfasser:	Qi, Shounan, Wang, Chenguang, Song, Delu, Song, Ying, Dunaief, Joshua L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - administration & dosage Antioxidants - therapeutic use Arthritis Cancer Cardiovascular diseases Catechin Catechin - administration & dosage Catechin - analogs & derivatives Catechin - therapeutic use Electroretinograms Electroretinography Epigallocatechin-3-gallate Green tea Injection Injections, Intraperitoneal Light - adverse effects Male Mice Mice, Inbred BALB C mRNA Neurodegeneration Neurodegenerative diseases Oxidative stress Oxidative Stress - genetics Photoreceptor Cells, Vertebrate - radiation effects Photoreceptors Radiation Injuries, Experimental - etiology Radiation Injuries, Experimental - physiopathology Radiation Injuries, Experimental - prevention & control Real-Time Polymerase Chain Reaction Retina Retina - physiopathology Retinal degeneration Retinal Degeneration - etiology Retinal Degeneration - physiopathology Retinal Degeneration - prevention & control RNA, Messenger - genetics Structure-function relationships Superoxide dismutase Superoxide Dismutase - genetics Tomography, Optical Coherence
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