Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

Infections with Shiga toxin (STx)-producing bacteria cause more than a million deaths each year and have no definitive treatment. To exert its cytotoxic effect, STx invades cells through retrograde membrane trafficking, escaping the lysosomal degradative pathway. We found that the widely available m...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2012-01, Vol.335 (6066), p.332-335
Hauptverfasser:	Mukhopadhyay, Somshuvra, Linstedt, Adam D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bacteria Bacterial diseases Bacterial infections Biological and medical sciences Cell Death Cell Membrane - metabolism cell membranes Cellular biology Cytotoxicity Dosage Endosomes Endosomes - metabolism Endosomes - ultrastructure Experimental bacterial diseases and models Golgi Apparatus - metabolism HeLa Cells Humans Infections Infectious diseases Lethal Dose 50 Lysosomes Lysosomes - metabolism Manganese Manganese - administration & dosage Manganese - pharmacology Medical sciences Medical treatment Metals Mice Miscellaneous physiological transport poisoning Protein Binding Protein Transport - drug effects Shiga toxin Shiga Toxin 1 - metabolism Shiga Toxin 1 - toxicity Shiga Toxins - metabolism Shiga Toxins - toxicity Signal transduction sorting tissue culture Toxicity Toxicology Toxins Vesicular Transport Proteins - chemistry Vesicular Transport Proteins - metabolism
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