IsomiR expression patterns in canonical and Dicer‑independent microRNAs
Multiple microRNA (miRNA) variants, known as isomiRs, are extensively distributed in miRNA loci and predominantly derive from the alternative cleavage of Drosha/Dicer and 3'addition events. The present study aimed to investigate the expression patterns of multiple isomiRs in typical miRNA and D...
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| Veröffentlicht in: | Molecular medicine reports 2017-03, Vol.15 (3), p.1071-1078 |
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| creator | Liang, Tingming Yu, Jiafeng Liu, Chang Guo, Li |
| description | Multiple microRNA (miRNA) variants, known as isomiRs, are extensively distributed in miRNA loci and predominantly derive from the alternative cleavage of Drosha/Dicer and 3'addition events. The present study aimed to investigate the expression patterns of multiple isomiRs in typical miRNA and Dicer‑independent miRNA loci by conducting evolutionary and expression analysis using public datasets. Although different miRNA maturation processes exist, multiple isomiRs can be detected by similar expression distributions. However, isomiR expression in Dicer‑independent miRNA loci tends to be at a moderate level, particularly for random distribution in the ends that are split by Dicer in the typical miRNA loci. Compared with the mature miRNA locus (dominant miRNA locus), the non‑dominant miRNA locus indicates an expression distribution similar to that of the Dicer‑independent miRNA locus. These results increase the understanding of multiple isomiRs in the progression of diseases. |
| doi_str_mv | 10.3892/mmr.2017.6117 |
| format | Article |
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The present study aimed to investigate the expression patterns of multiple isomiRs in typical miRNA and Dicer‑independent miRNA loci by conducting evolutionary and expression analysis using public datasets. Although different miRNA maturation processes exist, multiple isomiRs can be detected by similar expression distributions. However, isomiR expression in Dicer‑independent miRNA loci tends to be at a moderate level, particularly for random distribution in the ends that are split by Dicer in the typical miRNA loci. Compared with the mature miRNA locus (dominant miRNA locus), the non‑dominant miRNA locus indicates an expression distribution similar to that of the Dicer‑independent miRNA locus. These results increase the understanding of multiple isomiRs in the progression of diseases.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2017.6117</identifier><identifier>PMID: 28098889</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Biosynthesis ; Cancer ; Confidence intervals ; Databases, Nucleic Acid ; Disease susceptibility ; Evolution, Molecular ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation ; Genetic aspects ; Genetic Loci ; Genomes ; Health aspects ; Humans ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Mutation ; Phylogeny ; Pilot projects ; Software ; Studies ; Transcriptome ; Zebrafish</subject><ispartof>Molecular medicine reports, 2017-03, Vol.15 (3), p.1071-1078</ispartof><rights>COPYRIGHT 2017 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><rights>Copyright: © Liang et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-7e674c892fa5103b556035722e7d0fcae970b0fa591fe94faa68956d3c23e4633</citedby><cites>FETCH-LOGICAL-c509t-7e674c892fa5103b556035722e7d0fcae970b0fa591fe94faa68956d3c23e4633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28098889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Tingming</creatorcontrib><creatorcontrib>Yu, Jiafeng</creatorcontrib><creatorcontrib>Liu, Chang</creatorcontrib><creatorcontrib>Guo, Li</creatorcontrib><title>IsomiR expression patterns in canonical and Dicer‑independent microRNAs</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Multiple microRNA (miRNA) variants, known as isomiRs, are extensively distributed in miRNA loci and predominantly derive from the alternative cleavage of Drosha/Dicer and 3'addition events. The present study aimed to investigate the expression patterns of multiple isomiRs in typical miRNA and Dicer‑independent miRNA loci by conducting evolutionary and expression analysis using public datasets. Although different miRNA maturation processes exist, multiple isomiRs can be detected by similar expression distributions. However, isomiR expression in Dicer‑independent miRNA loci tends to be at a moderate level, particularly for random distribution in the ends that are split by Dicer in the typical miRNA loci. Compared with the mature miRNA locus (dominant miRNA locus), the non‑dominant miRNA locus indicates an expression distribution similar to that of the Dicer‑independent miRNA locus. These results increase the understanding of multiple isomiRs in the progression of diseases.</description><subject>Biosynthesis</subject><subject>Cancer</subject><subject>Confidence intervals</subject><subject>Databases, Nucleic Acid</subject><subject>Disease susceptibility</subject><subject>Evolution, Molecular</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation</subject><subject>Genetic aspects</subject><subject>Genetic Loci</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Humans</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Mutation</subject><subject>Phylogeny</subject><subject>Pilot projects</subject><subject>Software</subject><subject>Studies</subject><subject>Transcriptome</subject><subject>Zebrafish</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkcFq3DAQhkVpSLabHHsNhl5y8UayLMm6FJZNkywsKYTmLLTyONFiS67kLc0tr9BXzJNUZjdJGxCSYD7--Wd-hD4TPKOVLM67LswKTMSMEyI-oAkRkuQU4_Lj_l9IKY7Qpxg3GHNWMHmIjooKy6qq5AQtl9F39jaD332AGK13Wa-HAYKLmXWZ0c47a3SbaVdnF9ZAeH76Y10NPaTLDVlnTfC3N_N4jA4a3UY42b9TdHf57cfiOl99v1ou5qvcMCyHXAAXpUnOG80IpmvGOKZMFAWIGjdGgxR4jVNRkgZk2WjNK8l4TU1BoeSUTtHXnW6_XXdQm2Qi6Fb1wXY6PCqvrfq_4uyDuve_FKNcjGeKzvYCwf_cQhxUZ6OBttUO_DYqUnHCBBndTdGXd-jGb4NL4yki0w4lx4y9Ufe6BWVd41NfM4qqeSkpp4Jgmah8R6V9xRigebVMsBqjVClKNUapxigTf_rvnK_0S3b0Lwu_mjs</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Liang, Tingming</creator><creator>Yu, Jiafeng</creator><creator>Liu, Chang</creator><creator>Guo, Li</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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| subjects | Biosynthesis Cancer Confidence intervals Databases, Nucleic Acid Disease susceptibility Evolution, Molecular Gene expression Gene Expression Profiling Gene Expression Regulation Genetic aspects Genetic Loci Genomes Health aspects Humans MicroRNA MicroRNAs MicroRNAs - genetics miRNA Mutation Phylogeny Pilot projects Software Studies Transcriptome Zebrafish |
| title | IsomiR expression patterns in canonical and Dicer‑independent microRNAs |
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