Light responsive metal-organic frameworks as controllable CO-releasing cell culture substrates
A new carbon monoxide (CO)-releasing material has been developed by embedding a manganese carbonyl complex, MnBr(bpydc)(CO) (bpydc = 5,5'-dicarboxylate-2,2'-bipyridine) into a highly robust Zr(iv)-based metal-organic framework (MOF). Efficient and controllable CO-release was achieved under...
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| Veröffentlicht in: | Chemical science (Cambridge) 2017, Vol.8 (3), p.2381-2386 |
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| creator | Diring, Stéphane Carné-Sánchez, Arnau Zhang, JiCheng Ikemura, Shuya Kim, Chiwon Inaba, Hiroshi Kitagawa, Susumu Furukawa, Shuhei |
| description | A new carbon monoxide (CO)-releasing material has been developed by embedding a manganese carbonyl complex, MnBr(bpydc)(CO)
(bpydc = 5,5'-dicarboxylate-2,2'-bipyridine) into a highly robust Zr(iv)-based metal-organic framework (MOF). Efficient and controllable CO-release was achieved under exposure to low intensity visible light. Size-controllable nanocrystals of the photoactive MOF were obtained and their CO-releasing properties were correlated with their crystal sizes. The photoactive crystals were processed into cellular substrates with a biocompatible polymer matrix, and the light-induced delivery of CO and its subsequent cellular uptake were monitored using a fluorescent CO-probe. The results discussed here demonstrate a new opportunity to use MOFs as macromolecular scaffolds towards CO-releasing materials and the advantage of MOFs for high CO payloads, which is essential in future therapeutic applications. |
| doi_str_mv | 10.1039/c6sc04824b |
| format | Article |
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(bpydc = 5,5'-dicarboxylate-2,2'-bipyridine) into a highly robust Zr(iv)-based metal-organic framework (MOF). Efficient and controllable CO-release was achieved under exposure to low intensity visible light. Size-controllable nanocrystals of the photoactive MOF were obtained and their CO-releasing properties were correlated with their crystal sizes. The photoactive crystals were processed into cellular substrates with a biocompatible polymer matrix, and the light-induced delivery of CO and its subsequent cellular uptake were monitored using a fluorescent CO-probe. The results discussed here demonstrate a new opportunity to use MOFs as macromolecular scaffolds towards CO-releasing materials and the advantage of MOFs for high CO payloads, which is essential in future therapeutic applications.</description><identifier>ISSN: 2041-6520</identifier><identifier>EISSN: 2041-6539</identifier><identifier>DOI: 10.1039/c6sc04824b</identifier><identifier>PMID: 28451343</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Carbon monoxide ; Chemistry ; Correlation ; Crystals ; Fluorescence ; Metal-organic frameworks ; Payloads ; Scaffolds ; Substrates</subject><ispartof>Chemical science (Cambridge), 2017, Vol.8 (3), p.2381-2386</ispartof><rights>This journal is © The Royal Society of Chemistry 2017 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-c2f93cbcacd6fa60bf382a0727aa7eff0df1a80eac5728b4332da192d54f33bf3</citedby><cites>FETCH-LOGICAL-c595t-c2f93cbcacd6fa60bf382a0727aa7eff0df1a80eac5728b4332da192d54f33bf3</cites><orcidid>0000-0001-7108-3569 ; 0000-0003-3849-8038</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364997/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364997/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28451343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diring, Stéphane</creatorcontrib><creatorcontrib>Carné-Sánchez, Arnau</creatorcontrib><creatorcontrib>Zhang, JiCheng</creatorcontrib><creatorcontrib>Ikemura, Shuya</creatorcontrib><creatorcontrib>Kim, Chiwon</creatorcontrib><creatorcontrib>Inaba, Hiroshi</creatorcontrib><creatorcontrib>Kitagawa, Susumu</creatorcontrib><creatorcontrib>Furukawa, Shuhei</creatorcontrib><title>Light responsive metal-organic frameworks as controllable CO-releasing cell culture substrates</title><title>Chemical science (Cambridge)</title><addtitle>Chem Sci</addtitle><description>A new carbon monoxide (CO)-releasing material has been developed by embedding a manganese carbonyl complex, MnBr(bpydc)(CO)
(bpydc = 5,5'-dicarboxylate-2,2'-bipyridine) into a highly robust Zr(iv)-based metal-organic framework (MOF). Efficient and controllable CO-release was achieved under exposure to low intensity visible light. Size-controllable nanocrystals of the photoactive MOF were obtained and their CO-releasing properties were correlated with their crystal sizes. The photoactive crystals were processed into cellular substrates with a biocompatible polymer matrix, and the light-induced delivery of CO and its subsequent cellular uptake were monitored using a fluorescent CO-probe. The results discussed here demonstrate a new opportunity to use MOFs as macromolecular scaffolds towards CO-releasing materials and the advantage of MOFs for high CO payloads, which is essential in future therapeutic applications.</description><subject>Carbon monoxide</subject><subject>Chemistry</subject><subject>Correlation</subject><subject>Crystals</subject><subject>Fluorescence</subject><subject>Metal-organic frameworks</subject><subject>Payloads</subject><subject>Scaffolds</subject><subject>Substrates</subject><issn>2041-6520</issn><issn>2041-6539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkUuL1UAQhRtRnGGcjT9AeilCtJ9JeiNo8AUXZqFubSqd6jvRTvralczgvzfjjBfdTW2qoD4O53AYeyrFSym0exVqCsK0yvQP2KkSRla11e7h8VbihJ0TfRfbaC2tah6zE9UaK7XRp-zbbtxfLrwgHfJM4xXyCRdIVS57mMfAY4EJr3P5QRyIhzwvJacEfULeXVQFEwKN854HTImHNS1rQU5rT0uBBekJexQhEZ7f7TP29f27L93Hanfx4VP3ZlcF6-xSBRWdDn2AMNQRatFH3SoQjWoAGoxRDFFCKxCCbVTbG63VANKpwZqo9Uafsde3uoe1n3AIuPmE5A9lnKD88hlG__9nHi_9Pl95q2vjXLMJPL8TKPnnirT4aaSbUDBjXsnL1mlrZWPtPdC2dY0RWt0HNVJZZc2GvrhFQ8lEBePRvBT-pmnf1Z-7P02_3eBn_8Y9on971b8BnKCmUg</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Diring, Stéphane</creator><creator>Carné-Sánchez, Arnau</creator><creator>Zhang, JiCheng</creator><creator>Ikemura, Shuya</creator><creator>Kim, Chiwon</creator><creator>Inaba, Hiroshi</creator><creator>Kitagawa, Susumu</creator><creator>Furukawa, Shuhei</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7QO</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7108-3569</orcidid><orcidid>https://orcid.org/0000-0003-3849-8038</orcidid></search><sort><creationdate>2017</creationdate><title>Light responsive metal-organic frameworks as controllable CO-releasing cell culture substrates</title><author>Diring, Stéphane ; Carné-Sánchez, Arnau ; Zhang, JiCheng ; Ikemura, Shuya ; Kim, Chiwon ; Inaba, Hiroshi ; Kitagawa, Susumu ; Furukawa, Shuhei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c595t-c2f93cbcacd6fa60bf382a0727aa7eff0df1a80eac5728b4332da192d54f33bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Carbon monoxide</topic><topic>Chemistry</topic><topic>Correlation</topic><topic>Crystals</topic><topic>Fluorescence</topic><topic>Metal-organic frameworks</topic><topic>Payloads</topic><topic>Scaffolds</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diring, Stéphane</creatorcontrib><creatorcontrib>Carné-Sánchez, Arnau</creatorcontrib><creatorcontrib>Zhang, JiCheng</creatorcontrib><creatorcontrib>Ikemura, Shuya</creatorcontrib><creatorcontrib>Kim, Chiwon</creatorcontrib><creatorcontrib>Inaba, Hiroshi</creatorcontrib><creatorcontrib>Kitagawa, Susumu</creatorcontrib><creatorcontrib>Furukawa, Shuhei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Biotechnology Research Abstracts</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical science (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diring, Stéphane</au><au>Carné-Sánchez, Arnau</au><au>Zhang, JiCheng</au><au>Ikemura, Shuya</au><au>Kim, Chiwon</au><au>Inaba, Hiroshi</au><au>Kitagawa, Susumu</au><au>Furukawa, Shuhei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Light responsive metal-organic frameworks as controllable CO-releasing cell culture substrates</atitle><jtitle>Chemical science (Cambridge)</jtitle><addtitle>Chem Sci</addtitle><date>2017</date><risdate>2017</risdate><volume>8</volume><issue>3</issue><spage>2381</spage><epage>2386</epage><pages>2381-2386</pages><issn>2041-6520</issn><eissn>2041-6539</eissn><abstract>A new carbon monoxide (CO)-releasing material has been developed by embedding a manganese carbonyl complex, MnBr(bpydc)(CO)
(bpydc = 5,5'-dicarboxylate-2,2'-bipyridine) into a highly robust Zr(iv)-based metal-organic framework (MOF). Efficient and controllable CO-release was achieved under exposure to low intensity visible light. Size-controllable nanocrystals of the photoactive MOF were obtained and their CO-releasing properties were correlated with their crystal sizes. The photoactive crystals were processed into cellular substrates with a biocompatible polymer matrix, and the light-induced delivery of CO and its subsequent cellular uptake were monitored using a fluorescent CO-probe. The results discussed here demonstrate a new opportunity to use MOFs as macromolecular scaffolds towards CO-releasing materials and the advantage of MOFs for high CO payloads, which is essential in future therapeutic applications.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>28451343</pmid><doi>10.1039/c6sc04824b</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7108-3569</orcidid><orcidid>https://orcid.org/0000-0003-3849-8038</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Electronic Journals Library; Open Access: PubMed Central; DOAJ Directory of Open Access Journals; PubMed Central Open Access |
| subjects | Carbon monoxide Chemistry Correlation Crystals Fluorescence Metal-organic frameworks Payloads Scaffolds Substrates |
| title | Light responsive metal-organic frameworks as controllable CO-releasing cell culture substrates |
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