Ethyl acetate extract from Asparagus cochinchinensis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity

Asparagus cochinchinesis (A. cochinchinesis) is a medicine traditionally used to treat fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease in northeast Asian countries. Although numerous studies of the anti-inflammatory effects of A. cochinchinesis have been conducted...

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Veröffentlicht in:	Molecular medicine reports 2017-04, Vol.15 (4), p.1613-1623
Hauptverfasser:	Lee, Hyun Ah, Koh, Eun Kyoung, Sung, Ji Eun, Kim, Ji Eun, Song, Sung Hwa, Kim, Dong Seob, Son, Hong Joo, Lee, Chung Yeoul, Lee, Hee Seob, Bae, Chang Joon, Hwang, Dae Youn
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Acetic acid Animals Anti-Inflammatory Agents - pharmacology Antioxidants - metabolism Asparagus Asparagus cochinchinesis Asparagus Plant - chemistry Asthma Breast cancer Cell cycle Cell Cycle - drug effects Cell regulation Cough Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Cytokines - metabolism Enzyme regulation Ethanol Ethyl acetate Fever Free Radical Scavengers - pharmacology Health aspects Immune response Inflammation Inflammation Mediators - metabolism Inflammatory diseases Interleukin 10 Interleukin 6 Kinases Lipopolysaccharides Macrophages Macrophages - drug effects Macrophages - metabolism MAP kinase MAP Kinase Signaling System - drug effects Mice Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Observations Oxidative stress Phosphorylation Plant extracts Plant Extracts - pharmacology Protein kinase RAW 264.7 Cells RAW264.7 cells Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Signal transduction Studies Toxicity Transcription Tumor necrosis factor-TNF Tumor necrosis factor-α
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