Sophorae Flos extract inhibits RANKL-induced osteoclast differentiation by suppressing the NF-κB/NFATc1 pathway in mouse bone marrow cells

Sophorae Flos (SF) is a composite of flowers and buds of Styphnolobium japonicum (L.) Schott and has been used in traditional Korean and Chinese medicine for the treatment of hemostasis and inflammation. Previous studies reported that SF possesses anti-obesity properties, as well as anti-allergic, a...

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Veröffentlicht in:	BMC complementary and alternative medicine 2017-03, Vol.17 (1), p.164-164, Article 164
Hauptverfasser:	Kim, Jeong-Mi, Lee, Jung-Han, Lee, Guem-San, Noh, Eun-Mi, Song, Hyun-Kyung, Gu, Dong Ryun, Kim, Seong-Cheol, Lee, Seoung Hoon, Kwon, Kang-Beom, Lee, Young-Rae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-allergic agents bone formation bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism bone resorption Cells, Cultured complement dose response Down-Regulation - drug effects Flowers - chemistry hemostasis inflammation ligands macrophages Mice Mice, Inbred BALB C NF-kappa B - genetics NF-kappa B - metabolism NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism Oriental traditional medicine osteoclasts Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteogenesis - drug effects phospholipase C phosphorylation Plant Extracts - pharmacology quantitative polymerase chain reaction RANK Ligand - metabolism Signal Transduction - drug effects Sophora - chemistry Styphnolobium japonicum
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