Clinically Relevant Levels of 4-Aminopyridine Strengthen Physiological Responses in Intact Motor Circuits in Rats, Especially After Pyramidal Tract Injury

Background. 4-Aminopyridine (4-AP) is a Food and Drug Administration–approved drug to improve motor function in people with multiple sclerosis. Preliminary results suggest the drug may act on intact neural circuits and not just on demyelinated ones. Objective. To determine if 4-AP at clinically rele...

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Veröffentlicht in:	Neurorehabilitation and neural repair 2017-04, Vol.31 (4), p.387-396
Hauptverfasser:	Sindhurakar, Anil, Mishra, Asht M., Gupta, Disha, Iaci, Jennifer F., Parry, Tom J., Carmel, Jason B.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - blood 4-Aminopyridine - pharmacokinetics 4-Aminopyridine - pharmacology Animals Central Nervous System Agents - blood Central Nervous System Agents - pharmacokinetics Central Nervous System Agents - pharmacology Cervical Cord - drug effects Cervical Cord - injuries Cervical Cord - physiology Cervical Cord - physiopathology Drug Evaluation, Preclinical Electric Stimulation Electromyography Evoked Potentials, Motor - drug effects Evoked Potentials, Motor - physiology Female Forelimb - drug effects Forelimb - physiology Forelimb - physiopathology Microelectrodes Motor Cortex - drug effects Motor Cortex - physiology Motor Cortex - physiopathology Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Muscle, Skeletal - physiopathology Pyramidal Tracts - drug effects Pyramidal Tracts - injuries Pyramidal Tracts - physiology Pyramidal Tracts - physiopathology Random Allocation Rats, Sprague-Dawley Spinal Cord Injuries - drug therapy Spinal Cord Injuries - physiopathology
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